Antibacterial activity directed isolation of compounds from Onosma hispidum

Naz, Shazia; Ahmad, Samia; Rasool, Sheikh Ajaz; Sayeed, Syed Asad; Siddiqi, Rahmanullah

doi:10.1016/j.micres.2005.05.001

Cited by 116 publications

(73 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, trans-cinnamic acid derivatives, both isolated from plant sources or synthesized, are well known for their antioxidant [10], antitumor [11], antimicrobial [12] and antimycobacterial properties [13]. Cinnamic acid derivatives, especially those combining the cinnamoyl moiety with hydroxyl groups, present strong free radical scavenging properties.…”

Section: Introductionmentioning

confidence: 99%

Novel Cinnamic Acid Derivatives as Antioxidant and Anticancer Agents: Design, Synthesis and Modeling Studies

et al. 2014

View full text Add to dashboard Cite

Cinnamic acids have been identified as interesting compounds with antioxidant, anti-inflammatory and cytotoxic properties. In the present study, simple cinnamic acids were synthesized by Knoevenagel condensation reactions and evaluated for the above biological activities. Compound 4ii proved to be the most potent LOX inhibitor. Phenylsubstituted acids showed better inhibitory activity against soybean LOX, and it must be noted that compounds 4i and 3i with higher lipophilicity values resulted less active than compounds 2i and 1i. The compounds have shown very good activity in different antioxidant assays. The antitumor properties of these derivatives have been assessed by their 1/IC 50 inhibitory values in the proliferation of HT-29, A-549, OAW-42, MDA-MB-231, HeLa and MRC-5 normal cell lines. The compounds presented low antitumor activity considering the IC 50 values attained for the cell lines, with the exception of compound 4ii. Molecular docking studies were carried out on cinnamic acid derivative 4ii and were found to be in accordance with our experimental biological results.

show abstract

Section: Introductionmentioning

confidence: 99%

Novel Cinnamic Acid Derivatives as Antioxidant and Anticancer Agents: Design, Synthesis and Modeling Studies

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Natural products bearing the cinnamoyl moiety have attached much attention due to their broad spectrum of biological activities and low toxicity. Additionally, trans -cinnamic acid derivatives, both isolated from plant sources and synthesized, are well known for their antioxidant (Chung and Shin, 2007), antitumor (Bezerra et al, 2006), antimicrobial (Naz et al, 2006) and antimycobacterial properties (Carvalho et al, 2008). Cinnamic acid derivatives, especially those combining the cinnamoyl moiety with hydroxyl groups, present strong free radical scavenging properties.…”

Section: Discussionmentioning

confidence: 99%

Enhanced cytotoxic potential of Orthosiphon stamineus extract in MCF-7 cells through suppression of nucleolin and bcl2

Saravanan

Brindha

Sridharan

et al. 2017

Bangladesh J Pharmacol

View full text Add to dashboard Cite

The aim of the present study was to analyze the anti-cancer effect of Orthosiphon stamineus leaf extract on MCF-7 cells. Ethyl acetate extract of the plant was eluted and pooled into 6 fractions based on their Rf values and the fractions were tested for cytotoxicity. Fraction 3 was found effective (IC50 = 28.5 µL/mL) and was subjected to LC-MS analysis which indicated the presence of biochanin, eleutherol and cinnamic acid. Further, cytotoxic effect of the fraction was confirmed in terms of nucleolin, bcl2, bax and cytochrome c expression in MCF-7 cells through RT-PCR where a marked decrease in nucleolin, bcl2 and increase in bax and cytochrome c were observed. The presence of eleutherol, a well-known anti-oxidant and anti-cancer agent, has been reported for the first time in O. stamineus. The anti-cancer activity of O. stamineus may be due to the presence of elutherol and cinnamic acid.Video Clip of Methodology:LC-MS analysis of Orthosiphon stamineus extract: 7 min 33 sec <a href="https://youtube.com/v/7Vop4epRjB0">Full Screen</a> <a href="https://youtube.com/watch?v=7Vop4epRjB0">Alternate</a>

show abstract

“…These key cinnamyl alcohols are produced through two successive enzyme-catalyzed reductions starting from the corresponding cinnamyl SCoA-esters. In recent years, transcinnamic acid derivatives have also attracted much attention due to their antioxidative (Chung & Shin, 2007), antitumor (De et al, 2011a) and antimicrobial (Naz et al, 2006;Carvalho et al, 2008) properties.…”

Section: Fig 2 Cinnamic Acid and Its Natural Phenolic-analoguesmentioning

confidence: 99%