Antibacterial activities and phytochemical analysis of Cassia fistula (Linn.) leaf

Abstract

Cassia fistula Linn. which belongs to family Leguminosae is a medium-sized tree and its different parts are used in ayurvedic medicine as well as home remedies for common ailments. Sequential extraction was carried out using solvents viz. petroleum ether, chloroform, ethanol, methanol and water from leaf of the plant were investigated for preliminary phytochemical and antibacterial property. Results of the study showed that all the extracts had good inhibitory activity against Gram-positive test organism. Although all five extracts showed promising antibacterial activity against test bacterial species, yet maximum activity was observed in ethanol extract. The minimum inhibitory concentration ranged in between 94 to 1 500 μg/ml. Evaluation of phytochemicals such as alkaloids, flavonoids, carbohydrates, glycosides, protein and amino acids, saponins, and triterpenoids revealed the presence of most of constituents in polar extracts (ethanol, methanol, and aqueous) compared with nonpolar extracts (petroleum ether and chloroform). Furthermore, the ethanol extract was subjected to TLC bioautography and time-kill study against Staphylococcus epidermidis. All the findings exhibit that the leaf extracts have broad-spectrum activity and suggest its possible use in treatment of infectious diseases.

Phytochemical and antimicrobial properties of different plants and in silico investigation of their bioactive compounds in wound healing and rheumatism

“…Extracts showed that alkaloids, flavonoids, phenols, glycosides terpenoids, saponins, steroids, carbohydrates, proteins and tannins were mostly present in these plant extracts while, phylobatannins, emodins, anthocyanins and leucoanthocyanins were not present in these extracts. Our results are compatible to Rashmi and Naveen (2016) and Panda et al (2011) who also reported similar results.…”

Phytochemical and antimicrobial properties of different plants and in silico investigation of their bioactive compounds in wound healing and rheumatism

“…Extracts showed that alkaloids, flavonoids, phenols, glycosides terpenoids, saponins, steroids, carbohydrates, proteins and tannins were mostly present in these plant extracts while, phylobatannins, emodins, anthocyanins and leucoanthocyanins were not present in these extracts. Our results are compatible to Rashmi and Naveen (2016) and Panda et al (2011) who also reported similar results.…”

Effect of a selected Ayurvedic herbal formula in the management of Dadru Kushta (Tinea): A critical analysis

“…In the current investigation, the potential antibacterial activity of hydro alcohol extracts of the leaves of the ethno medicinal plant Cassia fistula was assessed against medically significant bacterial and fungus strains [24] . The hydro alcoholic and chloroform extracts of Cassia fistula were found to be more effective than conventional medications in the current studies on several isolated microorganisms and fungi [25] . Tribal people frequently utilize this herb to treat ringworm and other fungal skin infections among other ailment.…”

Antimicrobial Activity of Selected Banana Cultivars Against Important Human Pathogens, Including Candida Biofilm

“…Although extracts from all our cultivars show activity against Gram-positives, for Gram-negative pathogens the antibacterial profile depends more on the extraction solvent as well as the plant parts. This may be due to a lack of permeability of the lipopolysaccharide outer membrane of Gram-negatives, and many previous studies have already reported similar observations [27,35,36].…”

Phytochemical and antimicrobial properties of different plants and in silico investigation of their bioactive compounds in wound healing and rheumatism

“…Extracts showed that alkaloids, flavonoids, phenols, glycosides terpenoids, saponins, steroids, carbohydrates, proteins and tannins were mostly present in these plant extracts while, phylobatannins, emodins, anthocyanins and leucoanthocyanins were not present in these extracts. Our results are compatible to Rashmi and Naveen (2016) and Panda et al (2011) who also reported similar results.…”

Effect of a selected Ayurvedic herbal formula in the management of Dadru Kushta (Tinea): A critical analysis

“…In the current investigation, the potential antibacterial activity of hydro alcohol extracts of the leaves of the ethno medicinal plant Cassia fistula was assessed against medically significant bacterial and fungus strains [24] . The hydro alcoholic and chloroform extracts of Cassia fistula were found to be more effective than conventional medications in the current studies on several isolated microorganisms and fungi [25] . Tribal people frequently utilize this herb to treat ringworm and other fungal skin infections among other ailment.…”

Antimicrobial Activity of Selected Banana Cultivars Against Important Human Pathogens, Including Candida Biofilm

“…Although extracts from all our cultivars show activity against Gram-positives, for Gram-negative pathogens the antibacterial profile depends more on the extraction solvent as well as the plant parts. This may be due to a lack of permeability of the lipopolysaccharide outer membrane of Gram-negatives, and many previous studies have already reported similar observations [27,35,36].…”

Phytochemical and antimicrobial properties of different plants and in silico investigation of their bioactive compounds in wound healing and rheumatism

“…Extracts showed that alkaloids, flavonoids, phenols, glycosides terpenoids, saponins, steroids, carbohydrates, proteins and tannins were mostly present in these plant extracts while, phylobatannins, emodins, anthocyanins and leucoanthocyanins were not present in these extracts. Our results are compatible to Rashmi and Naveen (2016) and Panda et al (2011) who also reported similar results.…”

Effect of a selected Ayurvedic herbal formula in the management of Dadru Kushta (Tinea): A critical analysis

“…In the current investigation, the potential antibacterial activity of hydro alcohol extracts of the leaves of the ethno medicinal plant Cassia fistula was assessed against medically significant bacterial and fungus strains [24] . The hydro alcoholic and chloroform extracts of Cassia fistula were found to be more effective than conventional medications in the current studies on several isolated microorganisms and fungi [25] . Tribal people frequently utilize this herb to treat ringworm and other fungal skin infections among other ailment.…”

Antimicrobial Activity of Selected Banana Cultivars Against Important Human Pathogens, Including Candida Biofilm

“…Although extracts from all our cultivars show activity against Gram-positives, for Gram-negative pathogens the antibacterial profile depends more on the extraction solvent as well as the plant parts. This may be due to a lack of permeability of the lipopolysaccharide outer membrane of Gram-negatives, and many previous studies have already reported similar observations [27,35,36].…”