Antiarrhythmic Properties of Long-Term Treatment with Matrine in Arrhythmic Rat Induced by Coronary Ligation

Li, Xuelian; Chu, Weiming; Liu, Jinling; Xue, Xiangxin; Lu, Yanjie; Shan, Hongli; Yang, Baofeng

doi:10.1248/bpb.32.1521

Cited by 48 publications

(31 citation statements)

References 26 publications

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“…Actually, we do not know which is more effective in clinical use, for this kind of comparison must include many other factors, such as the side effects or the kinetics of the drugs, etc. However, Li et al, in their study on the antiarrhythmic properties of long-term treatment with matrine in rats with arrhythmia induced by coronary ligation, found that long term oral administration of Martine reduced arrhythmia and mortality more effectively than did amiodarone [35] .…”

Section: Discussionmentioning

confidence: 98%

Electrophysiological mechanisms of sophocarpine as a potential antiarrhythmic agent

Yang

Wang

et al. 2011

Acta Pharmacol Sin

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Aim: To examine the electrophysiological effects of sophocarpine on action potentials (AP) and ionic currents of cardiac myocytes and to compare some of these effects with those of amiodarone. Methods: Langendorff perfusion set-up was used in isolated guinea pig heart, and responses to sophocarpine were monitored using electrocardiograph. Conventional microelectrode, voltage clamp technique and perforated patch were employed to record fast response AP (fAP), slow response AP (sAP) and ionic currents in guinea pig papillary muscle or rabbit sinus node cells. Results: Tachyarrhythmia produced by isoprenaline (15 μmol/L) could be reversed by sophocarpine (300 μmol/L). Sophocarpine (10 μmol/L) decreased the amplitude by 4.0%, maximal depolarization velocity (V max ) of the fAP by 24.4%, and Na + current (I Na ) by 18.0%, while it prolonged the effective refractory period (ERP) by 21.1%. The same concentration of sophocarpine could also decrease the amplitude and V max of the sAP, by 26.8% and 25.7%, respectively, and attenuated the Ca 2+ current (I CaL ) and the K + tail current substantially. Comparison of sophocarpine with amiodarone demonstrated that both prolonged the duration and the ERP of fAP and sAP, both decreased the amplitude and V max of the fAP and sAP, and both slowed the automatic heart rate. Conclusion: Sophocarpine could reverse isoprenaline-induced arrhythmia and inhibit I Na , I CaL , and I Kr currents. The electrophysiological effects of sophocarpine are similar to those of amiodarone, which might be regarded as a prospective antiarrhythmic agent.

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Section: Discussionmentioning

confidence: 98%

Electrophysiological mechanisms of sophocarpine as a potential antiarrhythmic agent

Yang

Wang

et al. 2011

Acta Pharmacol Sin

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“…A total of 47% of the 155 anticancer drugs approved from 1950-2006 were natural products or directly derived from them (5). Matrine (C 15 H 24 N 2 O) is the major alkaloid component identified in Sophora alopecuroides roots, which are widely utilized in traditional Chinese medicine and have a wide range of pharmacological effects, including anti-cardiac, anti-arrhythmic, anti-bacterial, anti-asthma, anti-diuretic, immune suppressive and anti-inflammatory activities (6)(7)(8)(9). It has also been reported that matrine possesses antitumor activities in vitro and in vivo (10)(11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

Synthesis, biological evaluation and mechanism studies of matrine derivatives as anticancer agents

Jiang

Almosnid

et al. 2017

Oncology Letters

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Abstract.A total of five matrine derivatives were synthesized and evaluated for their anti-proliferation activity using a panel of four human cancer cell lines, including A549 lung, BT20 breast, MCF-7 breast and U2OS osteosarcoma cells. The YF3-5, YF3-7 and YF3-9, three novel compounds, demonstrated increased anti-proliferation activity compared with matrine, of which YF3-5 revealed the strongest anti-proliferation activity with a half-maximal inhibitory concentration value of 15.49-16.67 µM against the four human cancer cell lines. The anti-proliferation mechanism underlying YF3-5 was investigated in the A549 human lung cancer cell line and the results demonstrated that YF3-5 exerted its anti-proliferation activity through the induction of apoptosis and oxidative stress, in addition to arresting the cell cycle at the G 1 phase in a dose-dependent manner. IntroductionLung cancer is the primary cause of cancer-associated mortalities and is ranked the highest in males and second highest in females for mortality and morbidity rates globally (1). Non-small cell lung cancer (NSCLC), which constitutes 80-85% of lung cancer cases, remains an aggressive type of lung cancer that is associated with poor patient survival (2). Currently, chemotherapy has reached a plateau of effectiveness in improving patient survival, and it is the mainstay of treatment regimens and new drugs, including erlotinib and gefitinib, that they will eventually fail due to drug resistance (3,4); therefore, novel approaches and drugs are urgently required in order to improve the prognosis of patients with lung cancer.Natural compounds remain a predominant source for anticancer drug development. A total of 47% of the 155 anticancer drugs approved from 1950-2006 were natural products or directly derived from them (5). Matrine (C 15 H 24 N 2 O) is the major alkaloid component identified in Sophora alopecuroides roots, which are widely utilized in traditional Chinese medicine and have a wide range of pharmacological effects, including anti-cardiac, anti-arrhythmic, anti-bacterial, anti-asthma, anti-diuretic, immune suppressive and anti-inflammatory activities (6-9). It has also been reported that matrine possesses antitumor activities in vitro and in vivo (10-13). The mechanisms underlying matrine's antitumor activities include the inhibition of cell proliferation and the induction of apoptosis (14-16). However, the low water solubility, bioavailability and bioactivity of matrine, coupled with its considerable side effects, which include general toxicity to the central nervous system, have limited its utility as a therapeutic drug (17,18). Therefore, studies have been focusing on developing derivatives and analogues of matrine by total synthesis or structural modifications in order to improve its activity and bioavailability (19)(20)(21).A previous study demonstrated that the amide bond may be required for the antitumor activities of matrine as following opening of the D-ring and breaking of the amide bond, the anti-proliferative activities of matrine ...

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“…For patients with metastatic gastric cancer the survival rate is only 50%. Matrine, a natural alkaloid component that is derived from Sophora species plants and has a long history of being used in traditional Chinese medicine to treat inflammatory diseases and solid cancers, including gastric, liver, colon, lung, ovary, and breast cancers, and has been used in combination with chemotherapy or radiotherapy to reduce toxicity to normal cells [1][2][3] . In vitro and in vivo studies have demonstrated that matrine can inhibit the growth of various human tumor cell lines by promoting apoptosis through the upregulation of Bax expression and the downregulation of growth factor receptors such as Akt and nuclear factor-kappa B (NF-κB), which are involved in the epidermal growth factor (EGF)/vascular endothelial growth factor (VEGF)-VEGFR1-Akt-NF-κB signaling pathway.…”

Section: Introductionmentioning

confidence: 99%

Matrine inhibits the adhesion and migration of BCG823 gastric cancer cells by affecting the structure and function of the vasodilator-stimulated phosphoprotein (VASP)

Zhang

Shi

et al. 2013

Acta Pharmacol Sin

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Aim: Vasodilator-stimulated phosphoprotein (VASP) expression is upregulated in human cancers and correlates with more invasive advanced tumor stages. The aim of this study was to elucidate the mechanisms by which matrine, an alkaloid derived from Sophora species plants, acted on the VASP protein in human gastric cancer cells in vitro. Methods: VASP was expressed and purified. Intrinsic fluorescence spectroscopy was used to study the binding of matrine to VASP. CD spectroscopy was used to examine the changes in the VASP protein secondary structure. Human gastric carcinoma cell line BGC823 was tested. Scratch wound and cell adhesion assays were used to detect the cell migration and adhesion, respectively. Real-time PCR and Western blotting assays were used to measure mRNA and protein expression of VASP. Results: In the fluorescence assay, the dissociation constant for binding of matrine to VASP protein was 0.86 mmol/L, thus the direct binding between the two molecules was weak. However, matrine (50 μg/mL) caused obvious change in the secondary structure of VASP protein shown in CD spectrum. Treatments of BGC823 cells with matrine (50 μg/mL) significantly inhibited the cell migration and adhesion. The alkaloid changed the subcellular distribution of VASP and formation of actin stress fibers in BGC823 cells. The alkaloid caused small but statistically significant decreases in VASP protein expression and phosphorylation, but had no significant effect on VASP mRNA expression. Conclusion: Matrine modulates the structure, subcellular distribution, expression and phosphorylation of VASP in human gastric cancer cells, thus inhibiting the cancer cell adhesion and migration.

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Antiarrhythmic Properties of Long-Term Treatment with Matrine in Arrhythmic Rat Induced by Coronary Ligation

Cited by 48 publications

References 26 publications

Electrophysiological mechanisms of sophocarpine as a potential antiarrhythmic agent

Electrophysiological mechanisms of sophocarpine as a potential antiarrhythmic agent

Synthesis, biological evaluation and mechanism studies of matrine derivatives as anticancer agents

Matrine inhibits the adhesion and migration of BCG823 gastric cancer cells by affecting the structure and function of the vasodilator-stimulated phosphoprotein (VASP)

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