Antianxiety Drugs and Human Performance

RO 15‐1788 antagonises the central effects of diazepam in man without altering diazepam bioavailability.

“…The results of this study establish Ro 15-1788 as an effective antagonist of the cognitive, psychomotor and subjective effects of diazepam in man. The im-9 2'5 pairment in performance observed following diazepam alone was similar to that reported elsewhere (McNair, 1973;Kleinknecht & Donaldson, 1975; pam + Ro 15- Wittenborn, 1979). The data indicate that the most tual speed test severe performance decrements and mood changes wvith placebo.…”

A model for evaluation of antianxiety drugs with the use of experimentally induced stress: Comparison of nabilone and diazepam

“…Facilitation of performance is most easily shown when interference or competitive associates are designed into the task and also when anxiety-inducing conditions are present. 22 Medazepam, 5 mg, reduced the increase of heart rate during MDT testing in a paired competitive situation as compared with placebotreated subjects, even though performance on the MDT was not different. 29 We used two performance tests with conflict built into them, the MDT and the SCWT, to introduce stress.…”

Benzodiazepine Dependence

“…Despite of this apparent lack of published evidence, the extent of chronic usage of the benzodiazepines -although reflecting the chronic nature of their indications may mean that a proportion of users become dependent, even at normal therapeutic dosage. In view of the psychological impairment associated with chronic sedative ingestion [107] and the socioeconomic implications, a careful examination of the problem in an epidemiological framework is a matter of urgency. 11 ValzelH, L. (1967).…”