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Cited by 18 publications
(13 citation statements)
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“…Initially, all the atoms of the AChE receptor were fixed (rigid docking). Given that the geometries of compounds 17‐α and 17‐β are substantially different from donepezil, the relaxation of some side‐chains was expected and therefore, to account for this effect, similar docking runs were performed by including flexibility in the residues Tyr124, Ser203, Trp286, Tyr337, and Tyr341, which are known key residues in the active site (flexible docking) …”
Section: Methodsmentioning
confidence: 99%
“…Initially, all the atoms of the AChE receptor were fixed (rigid docking). Given that the geometries of compounds 17‐α and 17‐β are substantially different from donepezil, the relaxation of some side‐chains was expected and therefore, to account for this effect, similar docking runs were performed by including flexibility in the residues Tyr124, Ser203, Trp286, Tyr337, and Tyr341, which are known key residues in the active site (flexible docking) …”
Section: Methodsmentioning
confidence: 99%
“…Studies on the polar constituents of some Helichrysum species through hydro-methanolic, hydro-alcoholic, or methanol have identified caffeoylquinic and flavonoid derivatives as major constituents (Mari et al, 2014;Silva et al, 2017). The quinic acid derivative chlorogenic acid isolated from the methanol extract of H. italicum exhibited anti-adhesive activity against Pseudomonas aeruginosa (D' Abrosca et al, 2013).…”
Section: Biofilm Prevention and Disruptionmentioning
confidence: 99%
“…The synthesis of dibromo (1-5) tacrines via Friedländer reactions and disubstituted (7)(8)(9)(10)(11)(12)(13)(14) tacrine derivatives via metal assisted electrophilic and nucleophilic substituted reactions and MeI salt form (6) of unsubstituted tacrine were reported recently by our previous publications. 18,21 The isolated compounds (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14) were fully characterized with melting point, HRMS analysis, infrared, 1 H, 13 C, HMBC and HETCOR spectroscopy in this paper. 18 This study was carried out with disubstituted tacrine derivatives (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14) according to our previous paper.…”
Section: Chemistrymentioning
confidence: 99%
“…3 Adverse effects of some synthetic acetylcholinesterase inhibitors used for the treatment of AD such as tacrine and donepezil, leads to reseachers to find innocent and most potent derivatives of these drugs. [4][5] Therefore, it is very important to find new substances, more efficient and less expensive than the currently used drugs. Tacrine was the first AChE inhibitor to be launched and approved by FDA as an AD drug.…”
Section: Introductionmentioning
confidence: 99%