Anti-ulcerogenic activity of Gum Arabic in gastric mucosal injury induced by ethanol in male albino rats

Abstract

<jats:p> The present study was performed to evaluate the anti-ulcerogenic activity of Acacia senegal (Gum Arabic) against ethanol-induced gastric mucosal injury in rats. Thirty-six adult male albino rats were divided into 4 groups: group 1 served as a control; group 2 consisted of rats that received 15% of gum in drinking water for 2 weeks; group 3 comprised ulcerated animals administered 5 mL of ethanol/kg body weight by gavage; and group 4 consisted of rats received 15% of gum in drinking water for 2 weeks before ethanol administration. Superoxide dismutase (SOD) glutathione peroxidase (GPx), malondialdehyde (MDA), prostaglandin E<jats:sub>2</jats:sub> (PGE<jats:sub>2</jats:sub>), tumor necrosis factor alpha (TNF-α), interleukin (IL)-B1), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total protein, and albumin were assayed in addition to histological study. The results revealed that ethanol decreased SOD, GPx, and PGE<jats:sub>2</jats:sub> in tissue and serum total protein and albumin, while increased MDA in tissue, serum TNF-α, IL-B1, PGE<jats:sub>2</jats:sub>, ALT, AST, and ALP. Histological findings showed less edema and leucocytes infiltration compared with ulcer group. Furthermore, gum administration elevated PGE<jats:sub>2</jats:sub>, SOD, and GPx and significantly reduced MDA, TNF-α, and IL-B2. In conclusion, Gum Arabic can enhance gastric protection and sustain the integrity of the gastric mucosa. </jats:p><jats:p> Novelty The selected dose of Gum Arabic has the ability to decrease the pro-inflammatory cytokines in plasma and gastric tissue, thus enhancing gastric protection and maintaining the integrity of the gastric mucosa. Gum Arabic can compensate for the loss of antioxidants. </jats:p>

Manipulation of Gut Microbiota Using Acacia Gum Polysaccharide

“…16 Dysbiosis that happened in the gut could affect normal host systems, most often to the metabolic and immune process, thus causing diseases such as inflammatory bowel disease (IBD), 17,18 psoriatic arthritis, 19 type 1 and type 2 diabetes, 20,21 atopic eczema, 22 coeliac disease, 23,24 and arterial stiffness. 25 Over the last few decades, investigation on AG for its healthpromoting properties was studied and have shown positive effect like the regulation of autoimmune disease, 15 reduced duodenal inflammation in mice, 16 antiulcerogenicity on gastric mucosal injury in rats, 26 methane gas mitigation in ruminants, 27 and also the topical treatment of skin lesions of kwashiorkor children. 28 This research aims to investigate the impact of commercially available AG as a prebiotic source through in vitro colon model study.…”

“…Over the last few decades, investigation on AG for its health-promoting properties was studied and have shown positive effect like the regulation of autoimmune disease, reduced duodenal inflammation in mice, antiulcerogenicity on gastric mucosal injury in rats, methane gas mitigation in ruminants, and also the topical treatment of skin lesions of kwashiorkor children . This research aims to investigate the impact of commercially available AG as a prebiotic source through in vitro colon model study.…”

Curative Effects of Triphala Extract against Swim Stress-Induced Gastric Ulcers via Reduced Ulcer Index, Strengthened Gastric Mucosa and Improved Redox State in Rats

“…Among distinct strategies i.e., blockers of H2-receptor and proton pumps and anticholinergics, ranitidine has been widely accepted in targeting PUD but it elicits various adverse effects and drug interactions to different cellular components [13][14][15][16] . Therefore, various herbal formulations have been assessed for their pharmacological effects, particularly, gastrointestinal ailments [13,[17][18][19] .…”

Pretreatment with Lactobacillus fermentum XY18 Relieves Gastric Injury Induced by HCl/Ethanol in Mice via Antioxidant and Anti-Inflammatory Mechanisms

“…Then, after EGFR binds to the cell membrane, EGF can exert an antioxidant effect on target cells, thus alleviating gastric injury. 44 Similar to EGF, VEGF is a small peptide in the body. Enhanced EGFR expression can promote VEGF and angioprotein 1 expression, thus promoting the formation of blood vessels.…”