Anti‐U1RNP antibody and aseptic meningitis in connective tissue diseases

Okada, Jun; Hamana, Toshiyasu; Kondo, Hirobumi

doi:10.1080/03009740310003767

Cited by 22 publications

(12 citation statements)

References 7 publications

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“…Some studies have determined the presence of anti-U1RNP antibody [30] and have found high serum procalcitonin levels (≥0.5 ng/ml) [31]. It has been suggested that these methods may be useful to discriminate between septic and aseptic meningitis; however, few data exist for patients with SLE.…”

Section: Discussionmentioning

confidence: 99%

Clinical Characteristics and Outcomes of the Meningitides in Systemic Lupus Erythematosus

Baizabal‐Carvallo¹,

Delgadillo-Márquez

Estañol³

et al. 2008

Eur Neurol

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Background: The meningitides are rare but well-identified complications in patients with systemic lupus erythematosus (SLE). Aims: To determine the clinical characteristics, risk factors, prevalence and outcomes of the meningitides (septic and aseptic) in patients with SLE. Patients and Methods: From January 1988 to December 2006, we identified patients with SLE and septic or aseptic meningitis. Results: We identified 25 episodes of meningitis in 23 patients with SLE, from a total of 1,411 SLE patients (1.63%); in 15 out of 25 episodes, a microorganism was identified. Mycobacterium tuberculosis, Listeria monocytogenes and Criptococcus neoformans represented the main microorganisms. In 10 episodes, aseptic meningitis was diagnosed. Lymphopenia, steroid use, chronic damage and systemic activity of SLE were frequent in both kinds of meningitis. Although the clinical presentation did not differ significantly, patients with septic meningitis had more residual neurological deficits (p = 0.04). Conclusions: Meningitis was observed in about 1.6% of the patients with SLE; in 40% of the cases, no microorganism could be isolated. A residual neurological deficit was more common in patients with septic meningitis.

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Section: Discussionmentioning

confidence: 99%

Clinical Characteristics and Outcomes of the Meningitides in Systemic Lupus Erythematosus

Baizabal‐Carvallo¹,

Delgadillo-Márquez

Estañol³

et al. 2008

Eur Neurol

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“…Recent reports have clearly indicated that anti-ribosomal P [9,10] and anti-NR2 [11] Abs are linked to the depression-type psychiatric disorder and cognitive dysfunction, respectively. In addition, it has been reported that connective tissue disease (CTD) patients with aseptic meningitis tend to have anti-U1RNP Abs in the Japanese population [2]. CSF-anti-U1RNP Abs may have an important role in MCTD-associated aseptic meningitis in Case 2 because anti-U1RNP IgG Abs appeared to be more concentrated in CSF than in serum, especially in the acute phase.…”

Section: Discussionmentioning

confidence: 97%

“…In sera from Japanese aseptic meningitis patients with CTD, anti-U1RNP Abs are frequently recognized [2]. Several NSAIDs and other drugs induce aseptic meningitis, especially in patients with systemic lupus erythematosus (SLE) and MCTD [3].…”

Section: Introductionmentioning

confidence: 99%

Aseptic meningitis in mixed connective tissue disease: cytokine and anti-U1RNP antibodies in cerebrospinal fluids from two different cases

et al. 2008

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In this paper, we report two patients with mixed connective tissue disease (MCTD) who developed aseptic meningitis. In both cases, the concentrations of IFN-gamma and IL-6 in cerebrospinal fluid (CSF) were increased. In the first case, with non-steroidal anti-inflammatory drugs (NSAIDs)-induced meningitis, where anti-U1RNP antibodies (Abs) were not detected in CSF, NSAIDs induced both IFN-gamma and IL-6 secretion from peripheral blood mononuclear cells in vitro. In the second case, with disease-associated meningitis, anti-U1RNP Abs were detected also in CSF. Of note, anti-U1RNP Abs appeared to be more concentrated in CSF than in serum and CSF-anti-U1RNP Ab titer was correlated with disease activity. We suggest that IFN-gamma and IL-6 may be involved in both disease-associated and drug-induced aseptic meningitis, whereas CSF-anti-U1RNP Abs is detected only in a patient with MCTD-associated aseptic meningitis.

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“…4 Arinuma et al 5 reported that anti-NR2 Abs in the cerebrospinal fluid (CSF), but not in serum, were involved in diffuse central NPSLE. Okada et al 6 reported that 13 of 14 patients (seven SLE, five mixed connective tissue disease (MCTD) or overlap syndrome, one undifferentiated CTD, one Sjo¨gren's syndrome) with aseptic meningitis attributed to CTD had serum anti-U1 ribonucleoprotein (RNP) Abs. Recently, using an RNA-immunoprecipitation assay (RNA-IPP), we found that anti-U1RNP Abs were detected in CSF; anti-U1RNP Abs in CSF could be a useful biomarker of NP manifestations in SLE.…”

Section: Introductionmentioning

confidence: 99%

Association between anti-U1 ribonucleoprotein antibodies and inflammatory mediators in cerebrospinal fluid of patients with neuropsychiatric systemic lupus erythematosus

Yokoyama

Fujii

Kondo-Ishikawa

et al. 2014

Lupus

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Anti‐U1RNP antibody and aseptic meningitis in connective tissue diseases

Abstract: SLE or MCTD patients with aseptic meningitis tend to have anti-U1RNP antibody.

Cited by 22 publications

References 7 publications

Clinical Characteristics and Outcomes of the Meningitides in Systemic Lupus Erythematosus

Clinical Characteristics and Outcomes of the Meningitides in Systemic Lupus Erythematosus

Aseptic meningitis in mixed connective tissue disease: cytokine and anti-U1RNP antibodies in cerebrospinal fluids from two different cases

Association between anti-U1 ribonucleoprotein antibodies and inflammatory mediators in cerebrospinal fluid of patients with neuropsychiatric systemic lupus erythematosus

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