volume 11, issue 5, Pe0155050 2016
DOI: 10.1371/journal.pone.0155050
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Abstract: BackgroundCurrently ketogenic diets (KDs) are hyped as an anti-tumor intervention aimed at exploiting the metabolic abnormalities of cancer cells. However, while data in humans is sparse, translation of murine tumor models to the clinic is further hampered by small sample sizes, heterogeneous settings and mixed results concerning tumor growth retardation. The aim was therefore to synthesize the evidence for a growth inhibiting effect of KDs when used as a monotherapy in mice.MethodsWe conducted a Bayesian rand…

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