2005
DOI: 10.1007/s00280-005-0127-z
View full text |Buy / Rent full text
|
Sign up to set email alerts
|

Abstract: These data suggest that the anti-cancer activity of 5F 203 depends upon targets other than top1 or top2 and on the ability of this benzothiazole to form single-strand breaks and DNA-protein cross-links in cancer cells.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1

Citation Types

3
21
0

Year Published

2007
2007
2011
2011

Publication Types

Select...
5

Relationship

0
5

Authors

Journals

citations
Cited by 38 publications
references
References 24 publications
3
21
0
Order By: Relevance
“…We have been interested in the development of effective neuroprotective drugs, and have synthesized and examined various thiazole derivatives in cultured neuronal cells (Choi et al 2007;Kim et al 2010a, b, c). Thiazole derivatives are very interesting molecules for drug development, because they have been previously shown to be useful for treating various diseases, including neurodegenerative disorders (Urbani and Belluzzi 2000;Heiser et al 2002;Ishiyama et al 2004;Brantley et al 2006;Mortimer et al 2006;Pietrancosta et al 2006). For instance, the benzothiazole derivative AS601245 has shown beneficial effects in models of global and focal brain ischemia (Carboni et al 2004).…”
Section: Introductionmentioning
confidence: 98%
“…We have been interested in the development of effective neuroprotective drugs, and have synthesized and examined various thiazole derivatives in cultured neuronal cells (Choi et al 2007;Kim et al 2010a, b, c). Thiazole derivatives are very interesting molecules for drug development, because they have been previously shown to be useful for treating various diseases, including neurodegenerative disorders (Urbani and Belluzzi 2000;Heiser et al 2002;Ishiyama et al 2004;Brantley et al 2006;Mortimer et al 2006;Pietrancosta et al 2006). For instance, the benzothiazole derivative AS601245 has shown beneficial effects in models of global and focal brain ischemia (Carboni et al 2004).…”
Section: Introductionmentioning
confidence: 98%
“…Phortress (MacFadyen et al 2004;Brantley et al 2006) and aminoflavone (Kuffel et al 2002;Pobst and Ames 2006) are both in Phase I clinical trials at the moment. Flavones have been found to induce CYP1A1 and CYP1B1 gene expression in animals, and in in vitro cultivated human cells (Durgo et al 2007;Hodek et al 2006), possibly through modulation of the aryl hydrocarbon receptor (AhR) (Pohl et al 2006).…”
Section: Phytoestrogens As Natural Prodrugs In Cancer Preventionmentioning
confidence: 97%
“…A large range of benzothiazole derivatives were reported having anticancer (Brantley et al, 2006), anticonvulsant (Rana et al, 2008), antiinflammatory (Naik et al, 1996), and antimicrobial activities (Amir et al, 2009;Bondock et al, 2010;Franchini et al, 2009;Soni et al, 2010;Ebara et al, 2005) (Fig. 1).…”
Section: Introductionmentioning
confidence: 99%