Anti-Titin Antibodies in Myasthenia Gravis

Abstract

Anti-titin antibodies are a sensitive marker of thymoma associated with MG in patients 60 years and younger, justifying the insistent search for a thymoma in MG patients of this age group who have these antibodies. In nonthymoma patients, anti-titin antibodies represent an interesting marker complementary to the anti-AChR antibody titer, identifying a restricted subset of patients. These clinical correlations should prompt further studies to examine the mechanisms leading to the production of anti-titin antibodies.

The significance of titin antibodies in myasthenia gravis

“…The levels of titin antibodies in our MGT were 80 %, similar to that found in other studies [6,13,16]. Nearly 34 % of MGN [4,20]. Histological examination of the thymus indicates that titin antibodies, although lower in MG with lymphocytic predominantthymoma, were more common in MG with epithelial predominant-thymoma, mixed thymoma and spindlecell thymoma.…”

The significance of titin antibodies in myasthenia gravis

“…The levels of titin antibodies in our MGT were 80 %, similar to that found in other studies [6,13,16]. Nearly 34 % of MGN [4,20]. Histological examination of the thymus indicates that titin antibodies, although lower in MG with lymphocytic predominantthymoma, were more common in MG with epithelial predominant-thymoma, mixed thymoma and spindlecell thymoma.…”

Seroprevalence of neuronal antibodies in diseases mimicking autoimmune encephalitis

“…Previous reports regarding Yo and SOX-1 amongst other antibodies suggest high rate of false positive results that are not confirmable using alternative antibody detection methods 6 , 7 . Our data adds to these findings demonstrating that anti-titin and anti-recoverin were most commonly detectable by lineblot in serum,however, in none of the cases were consistent with previously described paraneoplastic phenotypes 14 , 15 and were found in miscellaneous neurological and non-neurological conditions. Moreover, for some antibodies, a positive correlation between definitive cases of PNS and lineblot band intensity has been established and might ease interpretation of commercial lineblot results 6 .…”

“…However, there is currently no evidence of the expression of these proteins in the nervous system making the relationship between these antibodies and LE doubtful 21 , 22 . Moreover, as shown in the present series, unless compatible with phenotypes described previously 14 , 15 , titin and recoverin positivity on commercial lineblot should not be used as the markers of LE as they are present in various non-autoimmune neurological disorders. Reports suggesting associations between titin or recoverin antibodies and limbic encephalitis, may potentially mislead future researchers and clinicians adding to the growing problem of misdiagnosis of AE and PNS.…”

Adult-onset Nemaline Myopathy Coexisting With Myasthenia Gravis

“… 6 Anti-titin antibody is a sensitive marker of thymoma associated with MG in elder patients. 7 Although we were unable to confirm thymoma in our patient due to his refusal to thymus resection, a mildly enhanced ovoid nodule at the posterior of sternum was found through CT scanning of chest. In addition, we found a high level of titin antibody in his serum.…”

The significance of titin antibodies in myasthenia gravis

“…The levels of titin antibodies in our MGT were 80 %, similar to that found in other studies [6,13,16]. Nearly 34 % of MGN [4,20]. Histological examination of the thymus indicates that titin antibodies, although lower in MG with lymphocytic predominantthymoma, were more common in MG with epithelial predominant-thymoma, mixed thymoma and spindlecell thymoma.…”

Seroprevalence of neuronal antibodies in diseases mimicking autoimmune encephalitis

“…Previous reports regarding Yo and SOX-1 amongst other antibodies suggest high rate of false positive results that are not confirmable using alternative antibody detection methods 6 , 7 . Our data adds to these findings demonstrating that anti-titin and anti-recoverin were most commonly detectable by lineblot in serum,however, in none of the cases were consistent with previously described paraneoplastic phenotypes 14 , 15 and were found in miscellaneous neurological and non-neurological conditions. Moreover, for some antibodies, a positive correlation between definitive cases of PNS and lineblot band intensity has been established and might ease interpretation of commercial lineblot results 6 .…”

“…However, there is currently no evidence of the expression of these proteins in the nervous system making the relationship between these antibodies and LE doubtful 21 , 22 . Moreover, as shown in the present series, unless compatible with phenotypes described previously 14 , 15 , titin and recoverin positivity on commercial lineblot should not be used as the markers of LE as they are present in various non-autoimmune neurological disorders. Reports suggesting associations between titin or recoverin antibodies and limbic encephalitis, may potentially mislead future researchers and clinicians adding to the growing problem of misdiagnosis of AE and PNS.…”

Adult-onset Nemaline Myopathy Coexisting With Myasthenia Gravis

“… 6 Anti-titin antibody is a sensitive marker of thymoma associated with MG in elder patients. 7 Although we were unable to confirm thymoma in our patient due to his refusal to thymus resection, a mildly enhanced ovoid nodule at the posterior of sternum was found through CT scanning of chest. In addition, we found a high level of titin antibody in his serum.…”

The significance of titin antibodies in myasthenia gravis

“…The levels of titin antibodies in our MGT were 80 %, similar to that found in other studies [6,13,16]. Nearly 34 % of MGN [4,20]. Histological examination of the thymus indicates that titin antibodies, although lower in MG with lymphocytic predominantthymoma, were more common in MG with epithelial predominant-thymoma, mixed thymoma and spindlecell thymoma.…”

Seroprevalence of neuronal antibodies in diseases mimicking autoimmune encephalitis

“…Previous reports regarding Yo and SOX-1 amongst other antibodies suggest high rate of false positive results that are not confirmable using alternative antibody detection methods 6 , 7 . Our data adds to these findings demonstrating that anti-titin and anti-recoverin were most commonly detectable by lineblot in serum,however, in none of the cases were consistent with previously described paraneoplastic phenotypes 14 , 15 and were found in miscellaneous neurological and non-neurological conditions. Moreover, for some antibodies, a positive correlation between definitive cases of PNS and lineblot band intensity has been established and might ease interpretation of commercial lineblot results 6 .…”

“…However, there is currently no evidence of the expression of these proteins in the nervous system making the relationship between these antibodies and LE doubtful 21 , 22 . Moreover, as shown in the present series, unless compatible with phenotypes described previously 14 , 15 , titin and recoverin positivity on commercial lineblot should not be used as the markers of LE as they are present in various non-autoimmune neurological disorders. Reports suggesting associations between titin or recoverin antibodies and limbic encephalitis, may potentially mislead future researchers and clinicians adding to the growing problem of misdiagnosis of AE and PNS.…”

Adult-onset Nemaline Myopathy Coexisting With Myasthenia Gravis

“… 6 Anti-titin antibody is a sensitive marker of thymoma associated with MG in elder patients. 7 Although we were unable to confirm thymoma in our patient due to his refusal to thymus resection, a mildly enhanced ovoid nodule at the posterior of sternum was found through CT scanning of chest. In addition, we found a high level of titin antibody in his serum.…”