Anti-thyroid antibodies and thyroid dysfunction in rheumatoid arthritis: Prevalence and clinical value

Atzeni, Fabiola; Doria, Andrea; Ghirardello, Anna; Turiel, M.; Batticciotto, Alberto; Carrabba, M; Sarzi-Puttini, Piercarlo

doi:10.1080/08916930701620100

Cited by 64 publications

(57 citation statements)

References 18 publications

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“…A study on an Italian population showed high occurrence of thyroid autoantibodies with low prevalence of hormonal alterations. 45 A meta-analysis on the prevalence of thyroid autoantibodies showed that there was increased prevalence of Tg and TPO antibodies, with OR of 3.1 and 2.3 respectively. 11 Nevertheless, when a subgroup analysis according to patients' geographical location was done, it showed that the American RA population did not have an increased rate of antithyroid antibodies, thus emphasizing the need for local studies.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of thyroid autoantibodies in patients with systematic autoimmune rheumatic diseases. Cross-sectional study

et al. 2017

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BACKGROUND: Thyroid autoimmunity is more common in patients with rheumatic diseases than in healthy populations. The degree of association seems subject to influence from patients' geographical location. Here, we aimed to ascertain the prevalence of thyroid autoantibodies in a cohort of patients with systemic rheumatic disease and the degree of association between its presence and inflammatory activity. DESIGN AND SETTING: Cross-sectional observational study in a rheumatology unit. METHODS: 301 patients with systemic lupus erythematosus (SLE), 210 with rheumatoid arthritis (RA), 58 with scleroderma (SSc) and 80 with spondyloarthritis (SpA) were studied regarding thyroid function (TSH and T4), anti-thyroglobulin (TgAb) and anti-thyroperoxidase (TPOab) and compared with 141 healthy controls. Disease activity in patients with rheumatic disease was assessed through appropriate indexes. RESULTS: There were more antithyroid antibodies in SLE patients with hypothyroidism (P = 0.01; odds ratio, OR 2.7; 95% confidence interval, CI: 1.20-6.26) and in those without hypothyroidism (P = 0.06; OR 2.4; 95% CI: 1.28-4.55) than in controls. SSc patients also showed P = 0.03 both with antithyroid antibodies and hypothyroidism (OR 3.4; 95% CI: 1.06-10.80) and without hypothyroidism (OR 3.1; 95% CI: 1.11-0.13). RA and SpA patients had the same prevalence as controls (P not significant). Presence of autoantibodies with and without hypothyroidism was not associated with the activity or functional indexes evaluated. CONCLUSION: SLE and SSc were associated with higher prevalence of thyroid autoantibodies in patients with and without hypothyroidism, unlike SpA and RA. There was no link between thyroid autoantibody presence and disease activity or functional impairment.

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Section: Discussionmentioning

confidence: 99%

Prevalence of thyroid autoantibodies in patients with systematic autoimmune rheumatic diseases. Cross-sectional study

et al. 2017

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“…Clinical observations demonstrated that co-manifestation of autoimmune disease within a single patient occurs more frequently than combined prevalence of underlying diseases predicts (7). Furthermore, patients with autoimmune disease are prone to develop additional autoantibody reactivities, for example an increased frequency of (i) anti-thyroid antibodies were found in rheumatoid arthritis (8); (ii) antinuclear antibodies (ANA) in pemphigus (9); or (iii) anti-CCP antibodies in rheumatoid arthritis (10). In contrast, it is not known whether different autoantibodies co-occur in individuals who are clinically healthy.…”

Section: Introductionmentioning

confidence: 99%

“…Several studies have suggested that MSCs have pleiotropic immunomodulatory effects, including the inhibition of T cell proliferation (4-6), suppression of natural killer (NK) cell proliferation (7), modulation of cytokine production (8), and inhibition of dendritic cell (DC) maturation (9,10). Although many soluble factors such as transforming growth factor-beta (TGF-b) (11,12) and IL-10 (13) have been reported to be involved in the immunomodulatory effects of MSCs, the exact mechanism underlying immunosuppression by MSCs remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Co‐occurrence of autoantibodies in healthy blood donors

Prüßmann

Recke

et al. 2014

Experimental Dermatology

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Autoimmune diseases are rare, but their incidence has increased over the past decades. Interestingly, the co-occurrence of autoimmune diseases is well documented; however, data on the presence of more than one specific autoantibody in healthy individuals are not available. Here, we investigated the prevalence of several autoantibodies in a cohort of over 6000 healthy persons. While individual autoantibodies were rarely detected (i.e. ranging from 0.3% for ANCA to 4.6% for anti-TPO), the cumulative prevalence of the tested autoantibodies was as high as 10%. Furthermore, our results demonstrate co-occurrence of ANA with specific autoantibodies that target TPO, CCP and Dsg1/3, while ANCA and autoantibodies to PCA and BP180/BP230 were not more frequent in ANA-positive compared to ANA-negative samples. This indicates that shared and independent mechanisms influence loss of tolerance to distinct sets of self-antigens.

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“…SGTD manifested as a "joint syndrome", which has not only the subjective and objective manifestations [8,9].…”

Section: Discussionmentioning

confidence: 99%

Influence of selenium on clinical and laboratory parameters in patients with rheumatoid arthritis and subclinical hypothyroid dysfunction

Knyazeva¹,

Комарова²,

Kuvichko³

2016

Russ. Open Med. J.

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Abstract:The article presents data on the effectiveness of the impact of selenium on clinical and laboratory parameters of rheumatoid arthritis (RA) in patients with subclinical hypothyroid dysfunction (SHTD). Aim -to study the influence of selenium on the clinical and laboratory parameters in patients with RA and SHTD. Material and Methods -The study included 78 patients with RA and SHTD. All patients underwent a complete clinical and functional, instrumental and laboratory examination for RA and thyroid dysfunction. Sodium selenite was added to the standard therapy of rheumatoid arthritis drug. Results -Our study showed that RA patients with concomitant SHTD after treatment with a complex scheme, which included the preparation of sodium selenite, improved articular syndrome activity of rheumatoid inflammation, reduced levels of thyroid stimulating hormon (TSH) and antithyroidperoxidase (aTPO), reduced the number of patients with elevated levels of aTPO (p<0.05). Conclusion -The use of sodium selenite in the treatment of RA patients with SHTD is an effective method of correction of the articular syndrome, reducing the levels of markers of inflammation and autoimmune manifestations of the whole process, which is very important and necessary to prevent the progression of the disease.

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Anti-thyroid antibodies and thyroid dysfunction in rheumatoid arthritis: Prevalence and clinical value

Abstract: Our study shows an increased prevalence of anti-thyroid antibodies in RA patients with a low prevalence of hormonal alterations. However, anti-thyroid antibodies do not seem to identify any peculiar RA phenotype.

Cited by 64 publications

References 18 publications

Prevalence of thyroid autoantibodies in patients with systematic autoimmune rheumatic diseases. Cross-sectional study

Prevalence of thyroid autoantibodies in patients with systematic autoimmune rheumatic diseases. Cross-sectional study

Co‐occurrence of autoantibodies in healthy blood donors

Influence of selenium on clinical and laboratory parameters in patients with rheumatoid arthritis and subclinical hypothyroid dysfunction

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