Anti-single-stranded DNA antibody and muscle involvement in localized scleroderma

Takehara, Kazuhiko

doi:10.1001/archderm.126.10.1368

Cited by 15 publications

(17 citation statements)

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“…We described ANA with a unique staining pattern on karyograms, which is distinct from anticentromere antibody, in 18 morphea patients [12]. Furthermore, an elevated level of anti-singlestranded DNA antibody in morphea patients has been reported by some investigators [13,14]. Harrington and Dunsmore [15] reported increased incidence of autoim mune disorders in patients with morphea.…”

Section: Discussionmentioning

confidence: 95%

Coexistence of Morphea and Systemic Sclerosis

et al. 1993

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While the association of morphea and systemic sclerosis (SSc) is considered to be a rare condition, we observed well-demarcated sclerotic skin changes indistinguishable from morphea in 9 of 135 SSc patients who visited our clinic during the last decade. We consider this rate of incidence (6.7%) to be high enough to consider morphea to be one of the skin involvements of SSc. There was a significantly (p < 0.01) higher incidence of morphea in males (3 of 5) than in females (6 of 130). Only 3 of Ill SSc patients positive for antinuclear antibody (ANA) also showed morphea, whereas 6 of 9 patients negative for ANA showed morphea (p < 0.01). Although the mechanism underlying the development of morphea in SSc patients remains unknown, our observations suggest a heterogeneous pathogenesis related to SSc gender and ANA type.

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Section: Discussionmentioning

confidence: 95%

Coexistence of Morphea and Systemic Sclerosis

et al. 1993

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“…Soluble IL-2R is reported to be parallel with disease activity (27,48). And ss-DNA is also a marker of disease activity, especially muscle involvement (49). As a result, there were no correlation (r , 0.4) between the serum let-7a levels and these four factors (Fig.…”

Section: Serum Levels Of Let-7a In Ssc/lsc Patientsmentioning

confidence: 94%

The Downregulation of microRNA let-7a Contributes to the Excessive Expression of Type I Collagen in Systemic and Localized Scleroderma

Makino

Jinnin

Hirano

et al. 2013

The Journal of Immunology

147

111

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Systemic and localized scleroderma (SSc and LSc) is characterized by excessive deposition of collagen and tissue fibrosis in the skin. Although they have fundamental common characteristics including autoimmunity, little is known about the exact mechanism that mediates the excessive collagen expression in these disorders. In the current study, we tried to evaluate the possibility that microRNAs (miRNAs) play some roles in the pathogenesis of fibrosis seen in these diseases. miRNA expression patterns were evaluated by miRNA array analysis, real-time PCR, and in situ hybridization. The function of miRNAs in dermal fibroblasts was assessed using miRNA inhibitors, precursors, or protectors. In the mouse model of bleomycin-induced dermal sclerosis, the overexpression of miRNAs was performed by i.p. miRNA injection. We demonstrated let-7a expression was downregulated in SSc and LSc skin both in vivo and in vitro, compared with normal or keloid skin. The inhibition or overexpression of let-7a in human or mouse skin fibroblasts affected the protein expression of type I collagen or luciferase activity of collagen 3′-untranslated region. Also, we found let-7a was detectable and quantitative in the serum and investigated serum let-7a levels in patients with SSc or LSc. let-7a concentration was significantly decreased in these patients, especially in LSc patients. Moreover, we revealed that the intermittent overexpression of let-7a in the skin by i.p. miRNA injection improved the skin fibrosis induced by bleomycin in mice. Investigation of more detailed mechanisms of miRNA-mediated regulation of collagen expression may lead to new therapeutic approaches against SSc and LSc.

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“…Localized scleroderma, especially generalized morphoea, has been reported to be accompanied by various immunological abnormalities, such as the deposition of immunoglobulins in the lesions, antinuclear antibodies (ANA), lupus erythematosus cell phenomenon, rheumatoid factor (RF) and anti-single-stranded DNA antibody (anti-ssDNA) [3][4][5][6][7][8]. The antigens recognized by ANA in localized scleroderma have not been thoroughly determined, but very recently we have found that the major antigens recognized by ANA in this disease are nuclear histones [9].…”

Section: Introductionmentioning

confidence: 99%

Demonstration of interleukin-2, interleukin-4 and interleukin-6 in sera from patients with localized scleroderma

et al. 1995

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Localized scleroderma has been reported to be accompanied by immunological abnormalities related to B cells, but little is known about T-cell activation in this disease. In this study, serum levels of interleukin-2 (IL-2), interleukin-4 (IL-4) and interleukin-6 (IL-6), which are known to be released by activated T cells, were determined using a sensitive enzyme-linked immunosorbent assay in 48 patients with localized scleroderma and 20 with systemic sclerosis, and in 20 healthy control subjects. IL-2, IL-4 and IL-6 were detected in serum from patients with localized scleroderma but not in that from healthy controls. The presence of antihistone antibodies correlated significantly with elevated IL-4 and IL-6 levels. Decreased serum levels of IL-2, IL-4 and IL-6 paralleled improvement in cutaneous sclerosis. Frequent detection of these lymphokines in serum from patients with localized scleroderma reflects T-cell activation in this disorder.

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Anti-single-stranded DNA antibody and muscle involvement in localized scleroderma

Cited by 15 publications

References 0 publications

Coexistence of Morphea and Systemic Sclerosis

Coexistence of Morphea and Systemic Sclerosis

The Downregulation of microRNA let-7a Contributes to the Excessive Expression of Type I Collagen in Systemic and Localized Scleroderma

Demonstration of interleukin-2, interleukin-4 and interleukin-6 in sera from patients with localized scleroderma

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