Anti-rheumatic Activities of Free Electron Laser Irradiation on Arthritis in Rats

Kuboyama, Noboru; Ohta, Mitsuhiro; Sakai, Takeshi; Nogami, K.; Nakao, Keisuke; Hayakawa, Katsumi; Sato, Isamu; Abiko, Yoshimitsu

doi:10.2530/jslsm.32.108

Cited by 2 publications

(2 citation statements)

References 29 publications

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“…rheumatoid effect by significantly inhibiting the increase of serum inflammatory cytokine and MMP-3 levels and thereby inhibiting the swelling of the hind leg, resorption and erosion of the calcaneus bone in collagen induced arthritis (CIA) rats 6,7) .…”

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confidence: 99%

Anti-inflammatory activities of light emitting diode irradiation on collagen-induced arthritis in mice (a secondary publication)

et al. 2014

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confidence: 99%

Anti-inflammatory activities of light emitting diode irradiation on collagen-induced arthritis in mice (a secondary publication)

et al. 2014

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“…This was caused by suppressing the expression of inflammatory cytokine genes. [7][8][9][10] In recent years, Kawano et al have shown that chronic inflammation in adipose tissue, especially abdominal visceral fat, has a major influence on the development of type 2 diabetes. In their experiments, they gave 60% high-fat diet to mice and observed increased production of Ccl2 which promotes macrophage accumulation in abdominal fat cells, thereby inducing chronic in-flammation in the large intestine.…”

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Effects of 830 nm low-power laser irradiation on body weight gain and inflammatory cytokines in experimental diabetes in different animal models

et al. 2019

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Background and aims: The present investigation was carried out to determine the levels of blood serum components and inflammatory cytokines in diabetic rat models [Goto-Kakizaki (GK), Zucker, and streptozotocin (STZ)-induced Sprague Dawley (SD) rats] which underwent abdominal Low-Power Laser Irradiation (LPLI) and compare them with non-irradiated controls. Methods: The animals were subdivided into the following groups: diabetic control rats (GK, Zucker, STZ) and diabetic rats treated with LPLI (GK + LPLI, Zucker + LPLI, and STZ + LPLI) (n = 7). The animals were irradiated three times weekly for 12 weeks in LPLI (830 nm) at a dose of 5 J/cm 2 for 500 s. Results: Body weight was significantly lowered in the Zucker-LPLI group compared to control at 10 weeks and this pattern was maintained until 12 weeks of age. TNF-α, IL-1I and IL-6 levels were significantly decreased (5.1 ± 1.1 vs 3.3 ± 0.5, p < 0.01; 43.6 ± 8.8 vs 27.1 ± 3.8, p < 0.01; 98.3 ± 15.8 vs 62.2 ± 12.1, p < 0.01) in the Zucker-LPLI group compared with the control rats. The small intestinal transit rates of charcoal meals were significantly decreased (58.1 ± 10.1 vs 73.4 ± 13.3, p < 0.05) in the Zucker-LPLI group compared with the control rats. Similarly, the serum levels of glucose, cholesterol and triglycerides of LPLI groups were decreased in comparison with that of diabetic control rats. Conclusions: We suggest that abdominal LPLI can reduce body weight and LPLI could be applicable for use against diabetic-induced inflammatory factors.

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Anti-rheumatic Activities of Free Electron Laser Irradiation on Arthritis in Rats

Cited by 2 publications

References 29 publications

Anti-inflammatory activities of light emitting diode irradiation on collagen-induced arthritis in mice (a secondary publication)

Anti-inflammatory activities of light emitting diode irradiation on collagen-induced arthritis in mice (a secondary publication)

Effects of 830 nm low-power laser irradiation on body weight gain and inflammatory cytokines in experimental diabetes in different animal models

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