2014
DOI: 10.1007/s10616-014-9758-4
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Abstract: Pterostilbene, a methoxylated analogue of resveratrol, is a natural compound primarily found in blueberries and several types of grapes. However, little is known about the effect of pterostilbene on the proliferation of hepatoma cells and its modes of actions. This study was undertaken to characterize its ability to suppress the proliferation of hepatoma AH109A cells and the possible mechanism(s) involved. Pterostilbene showed a significant and dose-dependent effect on the anti-proliferative activity against A… Show more

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Cited by 8 publications
(5 citation statements)
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References 30 publications
(35 reference statements)
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“…In agreement with recent research reporting the anti-tumor effect of PTE on various malignant cancers [22], we demonstrated that PTE can arrest cell cycle at G0/G1 phase. Additionally, protein analysis revealed that PTE increased the expression of p-CHK1, p-CHK2 and p21 and decreased the expression of CDK4, CDK6 and cyclin-D1.…”
Section: Discussionsupporting
confidence: 93%
“…In agreement with recent research reporting the anti-tumor effect of PTE on various malignant cancers [22], we demonstrated that PTE can arrest cell cycle at G0/G1 phase. Additionally, protein analysis revealed that PTE increased the expression of p-CHK1, p-CHK2 and p21 and decreased the expression of CDK4, CDK6 and cyclin-D1.…”
Section: Discussionsupporting
confidence: 93%
“…Although we did not determine whether it was selectively cytotoxic for neoplastic cells, Sun et al (25) demonstrated that the growth of normal human colon fibroblasts was not altered following 24 and 48-hour exposure to lower concentrations (5-40 µM) of pterostilbene. This result is also consistent with the findings of Dewi et al (39) who did not observe the antiproliferative activity of pterostilbene (12.5-100 µM) against normal myofibroblasts and skin fibroblasts.…”
Section: Discussionsupporting
confidence: 93%
“…Other studies on normal fibroblasts also state the non-toxicity of resveratrol at our observed potent anticancer concentrations [ 47 ]. Additionally, pterostilbene shows no toxicity at these concentrations in normal skin fibroblasts and myoblasts [ 48 ]. According to clinical studies, the safe dosage for resveratrol and pterostilbene is 5 g/day [ 49 ] and 250 mg/day [ 20 ], respectively.…”
Section: Discussionmentioning
confidence: 99%