Anti-proliferative and gene expression actions of resveratrol in breast cancer cells <i>in vitro</i>

Chin, Yu Tang; Hsieh, Meng-Chiao; Yang, Sheng; Tsai, Po Jung; Wang, Shwu Huey; Wang, Ching Chiung; Lee, Yee Hui; Cheng, Guei Yun; Huangfu, Wei; London, David; Tang, Heng Yuan; Fu, Earl; Yen, Yun; Liu, Leroy F.; Lin, Hung Yun; Davis, Paul J.

doi:10.18632/oncotarget.2632

Cited by 64 publications

(53 citation statements)

References 39 publications

(43 reference statements)

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“…In an experiment treating MDA-MB231 cells with resveratrol, it was found that 10 μM of resveratrol could reduce the percentage of proliferating cells to 33%, and even at a concentration as low as 0.1 μM, resveratrol could also induce more than a 50% decrease in cancer cell numbers compared to control group, which was in contrast to a previous study stating that the IC 50 values for inhibiting cell growth by resveratrol would be in the range of 5 to 10 μM (43). In other research with IC 50 of 60.5 μM to inhibit cell proliferation of MCF-7 cells (44), when treated with 30 μM of resveratrol, cell cycle showed a decrease of G0/G1 phase and G2/M phase accompanied with an increase in the S phase.…”

Section: Apoptosis Led By Cell Cycle Arrest: Importance Of P53 and P21contrasting

confidence: 81%

“…In breast cancer cell line MCF-7 and MDA-MB231, the elevation of ASPP1, which was induced as the target gene of increased E2F-1, might contribute to the up-regulation of p53 target genes Bax and p21, thereby sensitizing breast cancer cells to resveratrol-induced apoptosis (20). In an experiment treating MDA-MB231 cells with resveratrol, the downstream p53-dependent proapoptotic genes including p53, c-fos, c-jun, p21, PIG3, and BAD induced by resveratrol were also confirmed (43). Upstream of this molecular pathway was also suggested to be resveratrol's binding to integrin αvβ3, which caused subsequent activation of the ERK and/ or p38 kinase pathway to finally activate p53 (45).…”

Section: Apoptosis Led By Cell Cycle Arrest: Importance Of P53 and P21mentioning

confidence: 92%

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Anti-tumor effects and cellular mechanisms of resveratrol

Han

Xia

Gao

et al. 2015

DD&T

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Section: Apoptosis Led By Cell Cycle Arrest: Importance Of P53 and P21contrasting

confidence: 81%

Section: Apoptosis Led By Cell Cycle Arrest: Importance Of P53 and P21mentioning

confidence: 92%

Anti-tumor effects and cellular mechanisms of resveratrol

Han

Xia

Gao

et al. 2015

DD&T

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“…It was used as a natural plant compound in traditional Chinese and Japanese medicine (8,9). Recently, it has been reported that Res can inhibit proliferation and promote apoptosis of various types of cancer cells, such as pancreas, breast and colon cancer (10)(11)(12). For colon cancer, although the anticancer effect of Res has been validated (12), the specific mechanism underlying this activity remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Resveratrol inactivates PI3K/Akt signaling through upregulating BMP7 in human colon cancer cells

et al. 2017

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Abstract. Colon cancer is common worldwide and accounts for the significant cancer related morbidity and mortality in patients. Although extensive advancement has been made in colon cancer treatment and diagnosis in the last decades, there is still a giant gap between the clinical expectation. It has been reported that resveratrol (Res) may be a potential candidate for cancer treatment. However, the specific mechanism underlying this activity remains unclear. In this study, we investigated the anticancer activity of Res in human colon cancer cells, and unveiled the possible mechanism for this effect. With cell viability, flow cytometry, PCR and western blot analysis, we demonstrated the efficacious anticancer activity of Res in HCT116 cells. Mechanically, we found that Res greatly upregulates BMP7 in HCT116 cells. Exogenous BMP7 enhances the anticancer effect of Res in HCT116 cells, which was almost reversed by the BMP7 specific antibody. Res does not activate the BMPs/Smads signaling, but decreases the phosphorylation of Akt1/2/3 substantially in HCT116 cells. Exogenous BMP7 enhances the inhibitory effect of Res on the phosphorylation of Akt1/2/3, while BMP7 immunodepletion reverses this effect notably. Res markedly decreases the phosphorylation of PTEN, which can be enhanced by exogenous BMP7 but partly reversed by the BMP7 antibody. Our findings suggested that Res may be a promising candidate for colon cancer treatment, and the anticancer activity may be mediated by inactivating PI3K/Akt signaling through upregulating BMP7 to decrease, at least, the phosphorylation of

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“…Resveratrol, a polyphenol naturally occurring in grapes and red wine, is structurally similar to the DES [259]. Resveratrol suppresses the proliferation of breast cancer cells, induces apoptosis, inhibits the breast cancer stem cells and induces autophagy via suppressing the Wnt/β-catenin signaling pathway [53, 260, 261].…”

Section: Natural Products Against Er-positive Breast Cancermentioning

confidence: 99%

Role of dietary bioactive natural products in estrogen receptor-positive breast cancer

Bak

Gupta

Wahler

et al. 2016

Seminars in Cancer Biology

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Estrogen receptor (ER)-positive breast cancer, including luminal-A and -B, is the most common type of breast cancer. Extended exposure to estrogen is associated with an increased risk of breast cancer. Both ER-dependent and ER-independent mechanisms have been implicated in estrogen-mediated carcinogenesis. The ER-dependent pathway involves cell growth and proliferation triggered by the binding of estrogen to the ER. The ER-independent mechanisms depend on the metabolism of estrogen to generate genotoxic metabolites, free radicals and reactive oxygen species to induce breast cancer. A better understanding of the mechanisms that drive ER-positive breast cancer will help optimize targeted approaches to prevent or treat breast cancer. A growing emphasis is being placed on alternative medicine and dietary approaches toward the prevention and treatment of breast cancer. Many natural products and bioactive compounds found in foods have been shown to inhibit breast carcinogenesis via inhibition of estrogen induced oxidative stress as well as ER signaling. This review summarizes the role of bioactive natural products that are involved in the prevention and treatment of estrogen-related and ER-positive breast cancer.

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Anti-proliferative and gene expression actions of resveratrol in breast cancer cells in vitro

Cited by 64 publications

References 39 publications

Anti-tumor effects and cellular mechanisms of resveratrol

Anti-tumor effects and cellular mechanisms of resveratrol

Resveratrol inactivates PI3K/Akt signaling through upregulating BMP7 in human colon cancer cells

Role of dietary bioactive natural products in estrogen receptor-positive breast cancer

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