Anti-proliferative and anti-invasive effects of ferulic acid in TT medullary thyroid cancer cells interacting with URG4/URGCP

Dodurga, Yavuz; Eroğlu, Canan; Seçme, Mücahit; Elmas, Levent; Avcı, Çığır Biray; Şatıroğlu-Tufan, N. Lale

doi:10.1007/s13277-015-3984-z

Cited by 28 publications

(15 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, FA suppressed invasion, migration, and colony formation leading to cell cycle arrest, apoptosis, invasion, migration, and colony formation in TT human thyroid cancer cell line as was demonstrated by decrease in expression of novel gene URG4/URGCP, CCND1, CDK4, and 6, Bcl-2, MMP2, and MMP9 and significant increase in the expression of p53, PARP, PUMA, NOXA, Bax, Bid, caspases-3 and -9 [76]. Moreover, the derivative of FA; FXS-3 inhibited metastasis and proliferation in human lung cancer A549 cells.…”

Section: Ferulic Acidmentioning

confidence: 89%

Therapeutic Potential of Plant Phenolic Acids in the Treatment of Cancer

et al. 2020

View full text Add to dashboard Cite

Globally, cancer is the second leading cause of death. Different conventional approaches to treat cancer include chemotherapy or radiotherapy. However, these are usually associated with various deleterious effects and numerous disadvantages in clinical practice. In addition, there are increasing concerns about drug resistance. In the continuous search for safer and more effective treatments, plant-derived natural compounds are of major interest. Plant phenolics are secondary metabolites that have gained importance as potential anti-cancer compounds. Phenolics display a great prospective as cytotoxic anti-cancer agents promoting apoptosis, reducing proliferation, and targeting various aspects of cancer (angiogenesis, growth and differentiation, and metastasis). Phenolic acids are a subclass of plant phenolics, furtherly divided into benzoic and cinnamic acids, that are associated with potent anticancer abilities in various in vitro and in vivo studies. Moreover, the therapeutic activities of phenolic acids are reinforced by their role as epigenetic regulators as well as supporters of adverse events or resistance associated with conventional anticancer therapy. Encapsulation of phyto-substances into nanocarrier systems is a challenging aspect concerning the efficiency of natural substances used in cancer treatment. A summary of phenolic acids and their effectiveness as well as phenolic-associated advances in cancer treatment will be discussed in this review.

show abstract

Section: Ferulic Acidmentioning

confidence: 89%

Therapeutic Potential of Plant Phenolic Acids in the Treatment of Cancer

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Recently, numerous literatures have demonstrated the antitumor activities and protective effects of FA on thyroid cancer, prostate cancer, skin carcinogenesis, lung cancer, etc 6-9. Whereas the antitumor activities and its mechanism of FA in osteosarcoma remain still under discussion.…”

Section: Introductionmentioning

confidence: 99%

“…FA has been reported to induce apoptosis in TT thyroid cancer cells and LNCaP prostate cancer cells 6,7. However, whether FA could promote apoptosis in osteosarcoma is still mysterious.…”

Section: Introductionmentioning

confidence: 99%

Ferulic acid promoting apoptosis in human osteosarcoma cell lines

Zhang¹,

Wu²,

Yang³

2017

Pak J Med Sci

View full text Add to dashboard Cite

Objective:To explore the promoting apoptosis and antitumor activities of ferulic acid (FA) in human osteosarcoma and its potential mechanism.Methods:The SaOS-2 and MG63 osteosarcoma cell lines were opted to experiment and these cells were, respectively, cultured with various concentrations of FA (0 μM, 10 μM, 20 μM, 40 μM) for 72 hours at 37°C. The viabilities of the FA treated cells were monitored by MTT. Apoptosis cells were evaluated using annexin V/PI by flow cytometry. Apoptosis proteins caspase-3, procaspase-3, Bcl-2 and Bax were detected by western blot. Expressions of apoptotic genes Bcl-2 and Bax were quantified by qPCR.Results:The cell viabilities were critically declined in the concentration-dependent manner in FA groups (P < 0.01). The apoptosis cells were increased proportionately with the concentration of FA (P < 0.05). The procaspase-3 protein contents, and Bcl-2 mRNA and protein contents were significantly decreased while caspase-3 protein contents, and Bax mRNA and protein contents were concomitantly increased in the concentration-dependent manner in FA groups (P < 0.05). The response to FA by the SaOS-2 osteosarcoma cell was similar with the MG63 osteosarcoma cell (P > 0.05).Conclusion:Ferulic acid could significantly descend osteosarcoma cell viability through the promoting apoptosis pathway in which FA activates both caspase-3 and Bax and inactivates Bcl-2.

show abstract

“…Ferulic acid, a common dietary plant phenolic compound downregulated URG4/URGCP, CCND1, cyclin dependent kinases (CDK4, CDK6), BCL2, matrix metalloproteinase (MMP2, and MMP9). Moreover, pro‐apoptotic proteins (p53, PARP, PUMA, NOXA, BAX, BID) were found to be significantly upregulated in treated cancer cells …”

Section: Tgf/smad Mediated Signaling In Thyroid Cancermentioning

confidence: 99%

Signaling cascades in thyroid cancer: Increasing the armory of archers to hit bullseye

Rashid

Mansoor

Tabassum

et al. 2018

J of Cellular Biochemistry

View full text Add to dashboard Cite

Thyroid cancer is a multifaceted and therapeutically challenging disease and rapidly accumulating experimentally verified findings have considerably improve our understanding of the molecular mechanisms which underlie its development. Substantial fraction of information has been added into existing landscape of molecular oncology and we have started to develop a sharper understanding of the underlying mechanisms of thyroid cancer. Wealth of information demystified different intracellular signaling cascades which are frequently deregulated in thyroid cancer. In vitro assays and xenografted mice based studies have helped us to identify drug targets and different synthetic and natural products are currently being tested to effectively treat thyroid cancer. Cabozantinib and vandetanib have been approved to treat medullary thyroid cancer (MTC) and two agents (lenvatinib and sorafenib) are also being used to treat radioactive-iodine refractory differentiated thyroid cancer. This review comprehensively summarizes most recent advancements in our knowledge related to dysregulated intracellular signaling cascades in thyroid cancer and how different proteins can be therapeutically exploited. (1) We discuss how loss of TRAIL mediated apoptosis occurred in thyroid cancer cells and how different strategies can be used to restore apoptosis in resistant cancer cells; (2) We provide detailed account of seemingly opposite roles of NOTCH signaling in thyroid cancers; (3) TGF/SMAD mediated signaling also needs detailed research because of context dependent role in thyroid cancer. Researchers have only begun to scratch the surface of how TGF signaling works in thyroid cancer and metastasis; and (4) Role of SHH signaling in thyroid cancer stem cells is also well appreciated and targeting of SHH pathway will be an important aspect in treatment of thyroid cancer. Better concepts and improved knowledge will be helpful for clinicians in getting a step closer to individualized medicine.

show abstract

Anti-proliferative and anti-invasive effects of ferulic acid in TT medullary thyroid cancer cells interacting with URG4/URGCP

Cited by 28 publications

References 28 publications

Therapeutic Potential of Plant Phenolic Acids in the Treatment of Cancer

Therapeutic Potential of Plant Phenolic Acids in the Treatment of Cancer

Ferulic acid promoting apoptosis in human osteosarcoma cell lines

Signaling cascades in thyroid cancer: Increasing the armory of archers to hit bullseye

Contact Info

Product

Resources

About