Anti-Plasmodium falciparum activity of Aloe dawei and Justicia betonica

Bbosa, S.

doi:10.5897/ajpp12.479

Cited by 22 publications

(7 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, in vitro antimalarial test of ether leaves extracts of A. dawei using the chloroquine diphosphate as control has shown a potential inhibition of parasite growth against P. falciparum [33]. Similarly, Aloe perryi has been studied for its in vitro antiplasmodial activity and the result supports the use of the plant leaves latex in the treatment of malaria [34].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Antimalarial Activity of the Leaf Latex and TLC Isolates from Aloe megalacantha Baker in Plasmodium berghei Infected Mice

Hintsa

Sibhat

Karim

2019

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Malaria is a devastating parasitic disease which caused around 216 million cases and 445,000 deaths worldwide in 2016. This might be attributed to a wide spread of drug resistant parasites. The plant Aloe megalacantha is indigenous to Ethiopia where the sap of the leaves is traditionally used for the treatment of malaria. This study was aimed at evaluating the antimalarial effect of leaf latex and isolates obtained from Aloe megalacantha against chloroquine sensitive Plasmodium berghei ANKA strain in Swiss albino mice. Peters’ 4-day suppressive test method was used to test the antimalarial activity of both leaves latex and isolates. Three isolates were obtained using thin layer chromatography and were coded as AM1, AM2, and AM3 in ascending order of their retention factor. After treatment of Plasmodium berghei infected mice with leaf latex of Aloe megalacantha for four days at 100, 200, and 400 mg/kg, it shows 30.3%, 43.4%, and 56.4% suppression of the parasite growth, respectively. 32.3%, 51.3%, and 67.4% chemosuppression after treatment with AM1, 39.8%, 50.6%, and 64.2% chemosuppression after treatment with AM2, and 52.6%, 69.4%, and 79.6% chemosuppression after treatment with AM3 were observed at doses of 100, 200, and 400 mg/kg/day, respectively. The observed parasite suppression of leaves latex and isolates was statistically significant (P<0.05) as compared to negative control. Moreover, both the leaves latex and isolates were also observed to prevent Plasmodium berghei induced body weight loss and hypothermia and increased the survival time of Plasmodium berghei infected mice as compared to the negative control. Hence, the present study supports the traditional claim of the plant for the treatment of malaria.

show abstract

Section: Discussionmentioning

confidence: 99%

Evaluation of Antimalarial Activity of the Leaf Latex and TLC Isolates from Aloe megalacantha Baker in Plasmodium berghei Infected Mice

Hintsa

Sibhat

Karim

2019

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…According to a survey conducted on medicinal plants traditionally used for the treatment of malaria in eastern Ethiopia, Aloe species are among the most commonly-reported plants [9]. Other reports also indicate that the leaf latex of several Aloe species possesses genuine antiplasmodial activity [13,14,15,16]. Methods of the evaluation of the antimalarial activity of plant derivatives that rely on the in vivo treatment of rodents infected with P. berghei provide insights into the pharmacokinetics and immunological factors, but use non-human malaria parasites [17].…”

Section: Introductionmentioning

confidence: 99%

Antimalarial Activity of the Chemical Constituents of the Leaf Latex of Aloe pulcherrima Gilbert and Sebsebe

2016

View full text Add to dashboard Cite

Malaria is one of the three major global public health threats due to a wide spread resistance of the parasites to the standard antimalarial drugs. Considering this growing problem, the ethnomedicinal approach in the search for new antimalarial drugs from plant sources has proven to be more effective and inexpensive. The leaves of Aloe pulcherrima Gilbert and Sebsebe, an endemic Ethiopian plant, are locally used for the treatment of malaria and other infectious diseases. Application of the leaf latex of A. pulcherrima on preparative silica gel TLC led to the isolation of two C-glycosylated anthrones, identified as nataloin (1) and 7-hydroxyaloin (2) by spectroscopic techniques (UV, IR, 1 H-and 13 C-NMR, HR-ESIMS). Both the latex and isolated compounds displayed antimalarial activity in a dose-independent manner using a four-day suppressive test, with the highest percent suppression of 56.2% achieved at 200 mg/kg/day for 2. The results indicate that both the leaf latex of A. pulcherrima and its two major constituents are endowed with antiplasmodial activities, which support the traditional use of the leaves of the plant for the treatment of malaria.

show abstract

“…The plant contains several active components like 10H-indole [3,2-b] quinoline (Arunakumari et al, 2007), 6H-quinindoline (Subbaraju et al, 2004), jusbetonin (Subbaraju et al, 2004) and justicioside-A-G (Bbosa et al, 2013;Kanchanapoom et al, 2004Kanchanapoom et al, , 2005. These compounds possess analgesic, anti-inflammatory, anti-malarial, anti-microbial and antitumor activities (Arunakumari et al, 2007;Bbosa et al, 2013). The population number and size of J. betonica are very small in West Bengal, India (personal field survey observations).…”

Section: Introductionmentioning

confidence: 99%

Floral biology, breeding system and pollination ecology of Justicia betonica L. (Acanthaceae): An assessment of its low reproductive success in West Bengal, India

Layek¹,

Midday

Bisui

et al. 2022

Plant Species Biology

View full text Add to dashboard Cite

Besides its importance as an ornamental plant, Justicia betonica L. is also used as a medicinal plant for the treatment of several human disorders. However, the population size and abundance of the plant species are very low in Indian states, including West Bengal. The breeding system and pollination ecology of J. betonica are still unclear. Therefore, some reproductive aspects were investigated in order to provide important information for the sustainability of the species. The flowering duration spanned from December to May, with its peak in February–March. Flower opening time was much earlier (5.00–8.00 a.m.) on a hot day (in April–May) than on a cold day (10.00 a.m.–12.00 p.m. in December–January). The time of anther dehiscence coincided with the flower opening time; however, the stigma became receptive later. The plant species is self‐compatible but dependent on pollinators for fruit and seed sets. Members of different insect groups like ants, bees, butterflies, flies, moths and wasps visit the flowers. Among them, Allorhynchium metallicum and Halictus acrocephalus are the primary pollinators (based on the “relative pollinator service”). The plant species showed a significant pollination deficit (coefficient of pollination deficit [D] = 0.32) in the open condition. Larvae of the florivorous moth Gatesclarkeana erotias significantly reduced reproductive success by eating their floral parts, ovules and immature seeds. In conclusion, combining the pollination deficit and the feeding activity of phytophagous insects (moth larvae) may reduce the reproductive fitness of J. betonica in the study regions.

show abstract

Anti-Plasmodium falciparum activity of Aloe dawei and Justicia betonica

Cited by 22 publications

References 19 publications

Evaluation of Antimalarial Activity of the Leaf Latex and TLC Isolates from Aloe megalacantha Baker in Plasmodium berghei Infected Mice

Evaluation of Antimalarial Activity of the Leaf Latex and TLC Isolates from Aloe megalacantha Baker in Plasmodium berghei Infected Mice

Antimalarial Activity of the Chemical Constituents of the Leaf Latex of Aloe pulcherrima Gilbert and Sebsebe

Floral biology, breeding system and pollination ecology of Justicia betonica L. (Acanthaceae): An assessment of its low reproductive success in West Bengal, India

Contact Info

Product

Resources

About