Anti-photoaging potential of propolis extract in UVB-irradiated human dermal fibroblasts through increasing the expression of FOXO3A and NGF genes

Ebadi, Parimah; Fazeli, Mehdi

doi:10.1016/j.biopha.2017.08.019

Cited by 10 publications

(14 citation statements)

References 63 publications

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“…Finally, only a few data are currently available in the literature on the antiaging properties of propolis. For instance, Ebadi et al reported that pre-treatment of human dermal fibroblasts with propolis extracts prior to UVB exposure resulted in increased cell viability and reduced numbers of senescent, β-galactosidase-positive cells and led to upregulation of the FOXO3A and NGF genes in comparison to the untreated dermal fibroblasts [69]. Regarding the ability of propolis to down-regulate the expression of certain MMPs, Jin et al showed that propolis extracts significantly inhibited the MMP-9 activity in hepatocarcinoma cells [70], while Saavedra et al demonstrated that treatment of activated macrophage cells with ethanolic propolis extracts downregulated the expression of MMP-9 in a dose-dependent manner [71].…”

Section: Discussionmentioning

confidence: 99%

Propolis Extracts Inhibit UV-Induced Photodamage in Human Experimental In Vitro Skin Models

et al. 2019

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The aim of this study was to assess the antioxidant, photoprotective, and antiaging effects of Greek propolis. Propolis was subjected to n-heptane or methanol extraction. Total phenolic/flavonoid content and antioxidant potential were determined in the extracts. Promising extracts were evaluated for their cytoprotective properties using human immortalized keratinocyte (HaCaT) or reconstituted human skin tissue following exposure to UVB. Assessment of cytotoxicity, DNA damage, oxidative status, and gene/protein expression levels of various matrix metalloproteinases (MMPs) were performed. The propolis methanolic fractions exhibited higher total phenolic and flavonoid contents and significant in vitro antioxidant activity. Incubation of HaCaT cells with certain methanolic extracts significantly decreased the formation of DNA strand breaks following exposure to UVB and attenuated UVB-induced decrease in cell viability. The extracts had no remarkable effect on the total antioxidant status, but significantly lowered total protein carbonyl content used as a marker for protein oxidation in HaCaT cells. MMP-1, -3, -7, and -9, monitored as endpoints of antiaging efficacy, were significantly reduced by propolis following UVB exposure in a model of reconstituted skin tissue. In conclusion, propolis protects against the oxidative and photodamaging effects of UVB and could be further explored as a promising agent for developing natural antiaging strategies.

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Section: Discussionmentioning

confidence: 99%

Propolis Extracts Inhibit UV-Induced Photodamage in Human Experimental In Vitro Skin Models

et al. 2019

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“…Several lines of evidence describe anti-aging effects of royal jelly, bee pollen, and propolis both in humans and laboratory animals [ 2 , 33 , 34 , 35 ]. These three products are widely used as dietary supplements [ 36 , 37 , 38 , 39 ].…”

Section: Apitherapy As a Possible Complementary Treatment For Sarcmentioning

confidence: 99%

“…Thanks to its countless bioactive elements, propolis enjoys a range of versatile biological and pharmacological properties including antimicrobial, antiviral, antifungal, antioxidant, anti-inflammatory, antineoplastic, antiaging, and cytostatic properties. In addition, it is considered a perfect natural food preservative due to its antimicrobial activity [ 35 , 38 , 65 , 66 , 68 , 71 ]. Because of its enormous health-promoting activities, propolis is widely used as a dietary supplement in many countries, especially in Japan [ 37 , 38 , 39 ].…”

Section: Apitherapy As a Possible Complementary Treatment For Sarcmentioning

confidence: 99%

Apitherapy for Age-Related Skeletal Muscle Dysfunction (Sarcopenia): A Review on the Effects of Royal Jelly, Propolis, and Bee Pollen

Ali

Kunugi

2020

Foods

106

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The global pandemic of sarcopenia, skeletal muscle loss and weakness, which prevails in up to 50% of older adults is increasing worldwide due to the expansion of aging populations. It is now striking young and midlife adults as well because of sedentary lifestyle and increased intake of unhealthy food (e.g., western diet). The lockdown measures and economic turndown associated with the current outbreak of Coronavirus Disease 2019 (COVID-19) are likely to increase the prevalence of sarcopenia by promoting sedentarism and unhealthy patterns of eating. Sarcopenia has multiple detrimental effects including falls, hospitalization, disability, and institutionalization. Although a few pharmacological agents (e.g., bimagrumab, sarconeos, and exercise mimetics) are being explored in different stages of trials, not a single drug has been approved for sarcopenia treatment. Hence, research has focused on testing the effect of nutraceuticals, such as bee products, as safe treatments to prevent and/or treat sarcopenia. Royal jelly, propolis, and bee pollen are common bee products that are rich in highly potent antioxidants such as flavonoids, phenols, and amino acids. These products, in order, stimulate larval development into queen bees, promote defenses of the bee hive against microbial and environmental threats, and increase royal jelly production by nurse bees. Thanks to their versatile pharmacological activities (e.g., anti-aging, anti-inflammatory, anticarcinogenic, antimicrobial, etc.), these products have been used to treat multiple chronic conditions that predispose to muscle wasting such as hypertension, diabetes mellitus, cardiovascular disorder, and cancer, to name a few. They were also used in some evolving studies to treat sarcopenia in laboratory animals and, to a limited degree, in humans. However, a collective understanding of the effect and mechanism of action of these products in skeletal muscle is not well-developed. Therefore, this review examines the literature for possible effects of royal jelly, bee pollen, and propolis on skeletal muscle in aged experimental models, muscle cell cultures, and humans. Collectively, data from reviewed studies denote varying levels of positive effects of bee products on muscle mass, strength, and function. The likely underlying mechanisms include amelioration of inflammation and oxidative damages, promotion of metabolic regulation, enhancement of satellite stem cell responsiveness, improvement of muscular blood supply, inhibition of catabolic genes, and promotion of peripheral neuronal regeneration. This review offers suggestions for other mechanisms to be explored and provides guidance for future trials investigating the effects of bee products among people with sarcopenia.

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“…Research documents antiaging effects of several bee products including RJ and propolis [ 36 , 37 ]. Accordingly, this review is aimed at investigating the effect of bee products on PD.…”

Section: Apitherapy As a Possible Complementary Treatment For Parkmentioning

confidence: 99%

“…However, the antioxidant capacity of various types of propolis varies considerably depending on the type of plant exudates used for their production [ 31 ]. Because of its rich chemical composition, propolis has a wide range of several other therapeutic activities: antibacterial, antiviral, antifungal, anti-inflammatory, and anticarcinogenic anticholesterol properties [ 29 , 36 , 38 , 41 , 47 , 48 ]. Accordingly, propolis and its components have been used to promote wound healing and to treat several diseased conditions such as pulp problems, oral candidiasis, genital herpes, and ischemic stroke, to name a few [ 38 , 39 , 46 , 48 ].…”

Section: Apitherapy As a Possible Complementary Treatment For Parkmentioning

confidence: 99%

Apitherapy for Parkinson’s Disease: A Focus on the Effects of Propolis and Royal Jelly

Ali

2020

Oxidative Medicine and Cellular Longevity

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The vast increase of world’s aging populations is associated with increased risk of age-related neurodegenerative diseases such as Parkinson’s disease (PD). PD is a widespread disorder characterized by progressive loss of dopaminergic neurons in the substantia nigra, which encompasses a wide range of debilitating motor, emotional, cognitive, and physical symptoms. PD threatens the quality of life of millions of patients and their families. Additionally, public welfare and healthcare systems are burdened with its high cost of care. Available treatments provide only a symptomatic relief and produce a trail of noxious side effects, which increase noncompliance. Hence, researchers have recently focused on the use of nutraceuticals as safe adjunctive treatments of PD to limit its progress and associated damages in affected groups. Propolis is a common product of the beehive, which possesses a large number of therapeutic properties. Royal jelly (RJ) is a bee product that is fed to bee queens during their entire life, and it contributes to their high physical fitness, fertility, and long lifespan. Evidence suggests that propolis and RJ can promote health by preventing the occurrence of age-related debilitating diseases. Therefore, they have been used to treat various serious disorders such as diabetes mellitus, cardiovascular diseases, and cancer. Some evolving studies used these bee products to treat PD in animal models. However, a clear understanding of the collective effect of propolis and RJ as well as their mechanism of action in PD is lacking. This review evaluates the available literature for the effects of propolis and RJ on PD. Whenever possible, it elaborates on the underlying mechanisms through which they function in this disorder and offers insights for fruitful use of bee products in future clinical trials.

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Anti-photoaging potential of propolis extract in UVB-irradiated human dermal fibroblasts through increasing the expression of FOXO3A and NGF genes

Cited by 10 publications

References 63 publications

Propolis Extracts Inhibit UV-Induced Photodamage in Human Experimental In Vitro Skin Models

Propolis Extracts Inhibit UV-Induced Photodamage in Human Experimental In Vitro Skin Models

Apitherapy for Age-Related Skeletal Muscle Dysfunction (Sarcopenia): A Review on the Effects of Royal Jelly, Propolis, and Bee Pollen

Apitherapy for Parkinson’s Disease: A Focus on the Effects of Propolis and Royal Jelly

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