Anti-obesity Effect of Pinellia ternata Extract in Zucker Rats

Kim, Yoo-Jeong; Shin, Young-Oh; Ha, Young-Wan; Lee, Sang‐Hyun; jaekeun, oh; Kim, Yeong Shik

doi:10.1248/bpb.29.1278

Cited by 57 publications

(30 citation statements)

References 17 publications

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“…However, it is undoubted that several still unexplored natural sources of potential PPAR α modulators are available. Thus, the list reported in Table 175, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112 is should encourage natural product chemists to make efforts aimed at the detailed characterization of the active principle(s) responsible for the action of these extract.…”

Section: Natural Products Modulating Pparαmentioning

confidence: 99%

The potential of natural products for targeting PPAR α

Rigano

Sirignano

Taglialatela‐Scafati

2017

Acta Pharmaceutica Sinica B

124

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Peroxisome proliferator activated receptors (PPARs) α, -γ and -β/δ are ligand-activated transcription factors and members of the superfamily of nuclear hormone receptor. These receptors play key roles in maintaining glucose and lipid homeostasis by modulating gene expression. PPARs constitute a recognized druggable target and indeed several classes of drugs used in the treatment of metabolic disease symptoms, such as dyslipidemia (fibrates, e.g. fenofibrate and gemfibrozil) and diabetes (thiazolidinediones, e.g. rosiglitazone and pioglitazone) are ligands for the various PPAR isoforms. More precisely, antidiabetic thiazolidinediones act on PPARγ, while PPARα is the main molecular target of antidyslipidemic fibrates. Over the past few years, our understanding of the mechanism underlying the PPAR modulation of gene expression has greatly increased. This review presents a survey on terrestrial and marine natural products modulating the PPARα system with the objective of highlighting how the incredible chemodiversity of natural products can provide innovative leads for this “hot” target.

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Section: Natural Products Modulating Pparαmentioning

confidence: 99%

The potential of natural products for targeting PPAR α

Rigano

Sirignano

Taglialatela‐Scafati

2017

Acta Pharmaceutica Sinica B

124

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“…It is an important traditional Chinese medicinal plant and has been used widely for thousands of years in China. Its tuber has specific pharmacological properties, such as antiemetic, antiobesity, expectorant, antipyretic and styptic effects, among others [16,17]. P. ternata has been excessively exploited, which has resulted in a continual decrease in wild sources of the species annually.…”

Section: Introductionmentioning

confidence: 99%

A Comparative Proteomic Analysis of Pinellia ternata Leaves Exposed to Heat Stress

Zhu

et al. 2013

IJMS

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Pinellia ternata is an important traditional Chinese medicinal plant. The growth of P. ternata is sensitive to high temperatures. To gain a better understanding of heat stress responses in P. ternata, we performed a comparative proteomic analysis. P. ternata seedlings were subjected to a temperature of 38 °C and samples were collected 24 h after treatment. Increased relative ion leakage and lipid peroxidation suggested that oxidative stress was frequently generated in rice leaves exposed to high temperature. Two-dimensional electrophoresis (2-DE) was used to analyze heat-responsive proteins. More than 600 protein spots were reproducibly detected on each gel; of these spots, 20 were up-regulated, and 7 were down-regulated. A total of 24 proteins and protein species were successfully identified by MALDI-TOF/TOF MS. These proteins and protein species were found to be primarily small heat shock proteins (58%) as well as proteins involved in RNA processing (17%), photosynthesis (13%), chlorophyll biosynthetic processes (4%), protein degradation (4%) and defense (4%). Using 2-DE Western blot analysis, we confirmed the identities of the cytosolic class II small heat shock protein (sHSPs-CII) identified by MS. The expression levels of four different proteins [cytosolic class I small heat shock protein (sHSPs-CI), sHSPs-CII, mitochondrial small heat shock protein (sHSPs-MIT), glycine-rich RNA-binding protein (GRP)] were analyzed at the transcriptional level by quantitative real-time PCR. The mRNA levels of three sHSPs correlated with the corresponding protein levels. However, GRP was down-regulated at the beginning of heat stress but then increased substantially to reach a peak after 24 h of heat stress. Our study provides valuable new insight into the responses of P. ternata to heat stress.

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“…The pharmacological effects of P. ternata and Z. officinale have been demonstrated in a number of studies. P. ternata has antitussive, antiemetic and anti-inflammatory properties, while Z. officinale has been shown to exert antioxidant, anti-inflammatory and antitumor effects (11)(12)(13). Previous studies have also shown that that P. ternata and Z. officinale attenuate the asthmatic response induced by various allergens (14,15).…”

Section: Introductionmentioning

confidence: 99%

EBM84 attenuates airway inflammation and mucus hypersecretion in an ovalbumin-induced murine model of asthma

Shin

Lee

Jeon

et al. 2013

International Journal of Molecular Medicine

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Abstract. EBM84 is a traditional herbal medicine and a combination of extracts obtained from Pinellia ternata and Zingiber officinale. It is traditionally used to treat vomiting, nausea, sputum and gastrointestinal disorders, and functions is an effective expectorant. In this study, we evaluated the protective effects of EBM84 on asthmatic responses, particularly mucus hypersecretion in an ovalbumin (OVA)-induced murine model of asthma. We also analyzed EBM84 composition using high performance liquid chromatography. Animals were sensitized on days 0 and 14 via intraperitoneal injection using 20 µg OVA. On days 21, 22 and 23 after initial sensitization, the mice received an airway challenge with OVA (1% w/v in PBS) for 1 h using an ultrasonic nebulizer (NE-U12). EBM84 was administered by gavage to the mice at doses of 16.9, 33.8 and 67.5 mg/kg once daily from days 18 to 23. EBM84 administration significantly lowered elevated levels of interleukin (IL)-4, IL-13, eotaxin and immunoglobulin (Ig)E in the bronchoalveolar lavage fluid or plasma. Airway inflammation and mucus hypersecretion were attenuated following EBM84 administration. EBM84 also inhibited the overexpression of mucin 5AC (MUC5AC) induced by OVA challenge in lung tissue. This result was consistent with the immunohistochemistry results. Our results indicate that EBM84 effectively inhibited airway inflammation and mucus hypersecretion via the downregulation of T helper 2 (Th2) cytokines, which reduced MUC5AC expression. Therefore, EBM84 has potential as a useful medicine for the treatment of allergic asthma.

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Anti-obesity Effect of Pinellia ternata Extract in Zucker Rats

Cited by 57 publications

References 17 publications

The potential of natural products for targeting PPAR α

The potential of natural products for targeting PPAR α

A Comparative Proteomic Analysis of Pinellia ternata Leaves Exposed to Heat Stress

EBM84 attenuates airway inflammation and mucus hypersecretion in an ovalbumin-induced murine model of asthma

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