Anti-Müllerian hormone (AMH) as a good predictor of time of menopause

Kruszyńska, Aleksandra; Słowińska-Srzednicka, J

doi:10.5114/pm.2017.68591

Cited by 54 publications

(50 citation statements)

References 19 publications

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“…Anti-Müllerian hormone (AMH) in women is secreted by granulosa cells of antral follicles [ 1 , 2 ]. AMH is a member of transforming growth factor-beta (TGF-β) superfamily.…”

Section: Introductionmentioning

confidence: 99%

Association between cadmium and anti-Mullerian hormone in premenopausal women at particular ages

Lee

Chung

Jeong

et al. 2018

Ann of Occup and Environ Med

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BackgroundAnti-Mullerian hormone (AMH) in women is secreted by granulosa cells of antral follicles. AMH appears to be a very stable marker for ovarian function. It may be used to diagnosis cases of premature ovarian failure, polycystic ovary syndrome (PCOS), and ovarian tumors. It has been suggested that cadmium exposure can reduce female fecundity. The purpose of this study was to investigate whether environmental exposure to cadmium was associated with alterations in AMH with regards to age.MethodsIn a cross-sectional study, the data of premenopausal women living in Seoul, ranging from 30 to 45 of age was collected. The study included a total of 283 women who completed serum AMH and whole blood cadmium assessments. Linear regression analyses were used in order to examine the association between cadmium and AMH. Given that age was the strongest confounder in both cadmium and AMH concentrations, we stratified subjects by 5 years old and analyzed their data.ResultsGeometric mean concentrations of blood cadmium and AMH were 0.97 μg/L and 3.02 ng/ml, respectively. Total association between cadmium and AMH was statistically significant (adjusted coefficient = − 0.34 (0.15), p = 0.02). After stratification, the only age group with a negative association between cadmium and AMH were the women raging between 30 and 35 years (adjusted coefficient = − 0.43 (0.18), p = 0.01).ConclusionsThe results of this study suggest that environmental exposure to cadmium may alter the AMH level of premenopausal women, depending on their age group.

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“…Anti-Müllerian hormone (AMH) in women is secreted by granulosa cells of antral follicles [ 1 , 2 ]. AMH is a member of transforming growth factor-beta (TGF-β) superfamily.…”

Section: Introductionmentioning

confidence: 99%

Association between cadmium and anti-Mullerian hormone in premenopausal women at particular ages

Lee

Chung

Jeong

et al. 2018

Ann of Occup and Environ Med

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“…Anti-Müllerian hormone (AMH) which reflects ovarian reserve is one of the most important markers distinguishing the cause of amenorrhea and amenorrhea may be accompanied with abnormally high or low level of AMH such as PCOS and menopause. 9,10 Although the relationship between various reproductive hormone including follicular stimulating hormone (FSH), testosterone, androstenedione and depression have been previously studied in menopausal women or premenopausal women with menstrual abnormalities, 11,12 there are no study on the association between AMH levels and depression. This study was to examine the prevalence of depression in women with SA and investigate the relationship between serum AMH levels and depressive symptoms among these women.…”

Section: Introductionmentioning

confidence: 99%

The association between depression and anti-Müllerian hormone in premenopausal women with secondary amenorrhea

Jeon¹,

Kim²

2018

AMJ

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Background Mood disturbance has been described in women with menstrual abnormalities. Aims To access the prevalence of depression in patients with secondary amenorrhea (SA), and investigate the relationship between depressive scores and serum anti-Müllerian hormone (AMH) levels among these women. Methods Sixty-six women with SA completed the Centre for Epidemiological Studies-Depression Rating Scales (CES-D) and Hamilton-Depression Rating Scales (HAM-D) in a university hospital. Clinical and biochemical parameters were measured in all individuals, and their associations with depressive scores were analysed. Results Among the 66 patients with SA, 42 (63.6 per cent) were diagnosed with polycystic ovarian syndrome, followed by 14 patients (21.2 per cent) with unexplained chronic anovulation, and the remaining 10 (15.2 per cent) were identified as primary ovarian insufficiency or low ovarian reserve. In the analysis of CES-D Scales, 21 (31.8 per cent) women had scores indicative of depression. Serum AMH levels and antral follicle counts were lower in patients with depressive symptoms than those in patients without depressive symptoms. (4.76±4.77ng/ml vs. 10.49±7.52ng/ml (P=0.003), 10.67±6.20 vs. 14.78±7.35 (P=0.030), respectively). The CES-D and HAM-D scores also correlated negatively with serum AMH levels after adjusting age, body mass index and androgen level (γ=-0.429, P=0.001 and γ=-0.428, P=0.001). Conclusion This cross-sectional study showed that the prevalence of depression in SA patients was high and higher depressive scores were associated with lower serum AMH levels. This observation suggests that decreased AMH level may possibly be linked to a particular spectrum of depression in patients with SA.

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“…Anti-Mullerian hormone (AMH)’s serum concentration is significantly correlated with the amount of pre-antral and small follicles. 7 Thus, AMH is used as an effective marker of ovarian follicular reserve and ovarian senility. 8 , 9 Although there are several studies reporting a strong correlation between AMH elevation and PCOS phenotype as well as ovulatory dysfunction, whether morphological alterations in the ovary or biochemical-hormonal interactions play a major role in the hormone level elevation is still controversial.…”

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confidence: 99%

Can we use serum Anti-Mullerian hormone to differentiate the diagnosis between polycystic ovary syndrome patients and healthy women with polycystic ovarian morphology and regular menstrual cycles

Aydoğmuş

Kelekçi

Elmalı

et al. 2018

SMJ

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Objectives:To compare Anti-Mullerian hormone (AMH) concentrations between polycystic ovary syndrome (PCOS) patients and healthy women who have polycystic ovarian morphology (PCOM) with regular menstrual cycles, and to determine a diagnostic cutoff value for PCOS women during reproductive period.Methods:This study was carried out between February 2013 and October 2017 at the Department of Obstetrics and Gynecology, İzmir Katip Çelebi University Atatürk Training and Research Hospital, Izmir, Turkey. Seventy PCOS patients and 70 PCOM women with normal menstrual cycles were included in the study. Blood samples of the subjects were obtained following an 8-hour fast for AMH and biochemical assessments, serum gonadotropin, and androgen measurements.Results:The mean serum AMH levels of PCOS patients were found to be higher than PCOM women with normal menstrual cycles (p<0.01). The optimal serum AMH cutoff value for PCOS diagnosis was determined as 3.51 ng/ml (sensitivity 72.8%, specificity 75.7%).Conclusion:Serum AMH concentrations are significantly higher in PCOS patients independent from the ovarian morphology and number of follicles per ovary. Positive and negative predictive values of AMH in PCOS diagnosis were found to be 75% and 73.6%, respectively, with a cutoff value of 3.51 ng/mL.

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Anti-Müllerian hormone (AMH) as a good predictor of time of menopause

Cited by 54 publications

References 19 publications

Association between cadmium and anti-Mullerian hormone in premenopausal women at particular ages

Association between cadmium and anti-Mullerian hormone in premenopausal women at particular ages

The association between depression and anti-Müllerian hormone in premenopausal women with secondary amenorrhea

Can we use serum Anti-Mullerian hormone to differentiate the diagnosis between polycystic ovary syndrome patients and healthy women with polycystic ovarian morphology and regular menstrual cycles

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