Anti-Müllerian Hormone (AMH), antral follicle count (AFC), external morphometrics and fertility in Tabapuã cows

Maculan, Renata; Pinto, T. L. C.; Moreira, Guilherme Musse; Vasconcelos, G. L. de; Sanches, Jesus Afonso; Rosa, Renata Lopes; Bonfim, Rafael Ribeiro; Gonçalves, Tarcisio de Moraes; Souza, José Camisão de

doi:10.1016/j.anireprosci.2017.12.011

Cited by 20 publications

(5 citation statements)

References 25 publications

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“…The level of AMH and AFC were consistent, and could reflect the ovarian reserve [22,23]. When antral follicles develop and become larger, AMH expression decreases gradually [24]. Thus, the number of small antral follicles increases, when the level of AMH increases, which leads to fewer mature antral follicles, failure to provide the necessary substrates for estrogen generation, and furthermore, to hyperandrogenism (such as high testosterone, DHEA) and ovarian dysfunction [25].…”

Section: Discussionmentioning

confidence: 83%

Human follicular fluid shows diverse metabolic profiles at different follicle developmental stages

Yang

Feng

et al. 2020

Reprod Biol Endocrinol

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Background: To investigate the metabolic profiles in the follicular fluid (FF) samples from patients undergoing in vitro fertilization (IVF) and to analyze the correlations with follicular development. Methods: The FF samples were obtained from participants (N = 26) who were receiving IVF under the gonadotropin-releasing hormone agonist (GnRH-a) long protocol stimulation and were collected separately from small (8-13 mm) and large (17-22 mm) follicles at the time of oocyte retrieval. Metabolomic analysis of the FF samples was performed using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Results: The results demonstrated that the size of the follicle influences the metabolic signature of the FF according to the profile and differential metabolites. Dehydroepiandrosterone (DHEA), which is enriched in steroid hormone biosynthesis, correlated negatively with the oocyte maturation rate and the high-quality embryo rate, and thus could be used to estimate the predictive diagnostic potential of follicular development. Conclusion: The FF has different metabolic characteristics in different stages of follicular development. Exploring meaningful metabolites could predict follicular development, and modifications of these metabolites could influence follicular development.

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Section: Discussionmentioning

confidence: 83%

Human follicular fluid shows diverse metabolic profiles at different follicle developmental stages

Yang

Feng

et al. 2020

Reprod Biol Endocrinol

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“…AMH has the potential to be used as a reliable fertility biomarker in cattle (Umer et al., 2019), which it is in other animals as well as humans (La Marca & Volpe, 2006). There are many studies showing a positive association between AMH concentration and fertility outcomes (Akbarinejad et al., 2018; Maculan et al., 2018; Okawa et al., 2021; Ribeiro et al., 2014), as well as with longevity (Alward et al., 2021; Jimenez‐Krassel et al., 2015; Okawa et al., 2021). However, other studies found no association between AMH concentration and future reproductive potential (Alward et al., 2021; Grala et al., 2021; Jimenez‐Krassel et al., 2015).…”

Section: Discussionmentioning

confidence: 99%

Association between maternal growth in the pre‐conception and early gestational period of nulliparous dairy heifers with anti‐Müllerian hormone in their female offspring

Thomson,

Beltman,

Crowe

et al. 2023

Reprod Domestic Animals

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Anti‐Müllerian hormone (AMH) is secreted by granulosa cells of healthy, growing follicles and is positively correlated with the ovarian reserve. Maternal and environmental factors, such as nutrition, disease, parity and endocrine disruptors, are thought to have a profound impact on ovarian reserve development during early foetal life. For genetic progress, it can be advantageous to breed dairy replacements from heifers to expedite the generation interval; however, there is some evidence that nulliparous animals produce female offspring with smaller ovarian reserves compared with multiparous animals. The objective of this prospective, observational study was to determine whether maternal growth in the pre‐conception and early gestational period of nulliparous dairy heifers is associated with pre‐weaning AMH concentrations in their female offspring. Our hypothesis was that excessive growth in this period would negatively impact AMH concentrations. Seasonal, pasture‐based dairy heifer calves (n = 156) born from nulliparous dams, from six Irish farms, were blood sampled at an average of 60 days of age in spring 2022 and tested for AMH. Mixed‐effects linear regression models were constructed with Box‐Cox transformed AMH concentration as the dependent variable. The independent variables tested included maternal average daily gain (ADG) from pre‐breeding examination (PBE) to pregnancy diagnosis (PD) between 30 and 60 days in calf (DIC), ADG from PBE to PD over 60 DIC and ADG between the two PDs. Calf breed and age at sampling were forced into the models, and the farm was treated as a random effect in all models. We found that as ADG increased from the pre‐breeding period to their first PD visit, the AMH concentration in their offspring reduced. However, ADG explained only a small amount of the variation in AMH concentrations (marginal R2 = 0.041). In conclusion, the results of our study suggest that excessive growth prior to conception and in early gestation of nulliparous heifers could impact the ovarian reserve of their female offspring, and may imply that farmers should avoid excessive growth in the immediate pre‐breeding and early gestational periods.

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“…External genitalia was measured using a universal caliper (Digimess, São Paulo, Brazil), as follows: vulva width measured from the lateral edges from the rima midpoint at 90º (angle) and rima between the dorsal and ventral commissure, as described by Maculan et al (2018).…”

Section: Vulva Lengthmentioning

confidence: 99%

Reproductive development of dairy heifers in an integrated livestock-forest system during the summer

Dias,

Camargo,

Oliveira

et al. 2023

Anim. Reprod.

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This study aimed to assess the cortisol, body and reproductive development of prepubertal Holstein and Holstein-Gir ¾ heifers at 27 months of age maintained in an integrated livestock-forest (ILF) system for 60 summer days compared to the monoculture system in full sun (FS). The ILF system promoted changes (P=0.02) in the cortisol levels of Holstein-Gir ¾ heifers and did not affect weight gain in any of the breed groups studied. Animals in ILF system presented a lower (P=0.006) vulvar development for the rima height parameter and similar for the vulva width parameter. The ovarian follicular population of Holstein-Gir ¾ heifers in the ILF system was lower (P=0.004); however, for the Holstein heifers, no statistical difference was found, and numbers were higher (P=0.08) in the ILF system. None of the other ovarian parameters studied had any changes, and we also found important racial differences. Weight gain (P=0.003), vulvar development (P<0.001), and mean follicular size (P=0.008) were higher in the Holstein-Gir ¾ animals. Based on such results, the effect of the ILF system at 27 months of age on stress and reproductive parameters in the Holstein breed is considered positive, although negative effects have been detected on reproductive parameters in the Holstein-Gir ¾ breed.

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Anti-Müllerian Hormone (AMH), antral follicle count (AFC), external morphometrics and fertility in Tabapuã cows

Cited by 20 publications

References 25 publications

Human follicular fluid shows diverse metabolic profiles at different follicle developmental stages

Human follicular fluid shows diverse metabolic profiles at different follicle developmental stages

Association between maternal growth in the pre‐conception and early gestational period of nulliparous dairy heifers with anti‐Müllerian hormone in their female offspring

Reproductive development of dairy heifers in an integrated livestock-forest system during the summer

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