Anti-Müllerian hormone: a critical factor for female fertility and reproductive health

Rzeszowska, Marzena; Leszcz, Agnieszka; Putowski, Lechosław; Hałabiś, Magdalena; Tkaczuk-Włach, Joanna; Kotarski, Jan; Polak, Grzegorz

doi:10.5603/gp.2016.0039

Cited by 5 publications

(5 citation statements)

References 26 publications

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“…The (GnRH) antagonist regimens and low initial gonadotropin doses are recommended. It's also crucial to bring women to fertility treatment clinics as soon as possible so that they may select the best treatment option for them [23]. Letrozole has become a key weapon in our arsenal for treating infertility, but it has received relatively little attention in terms of improving its efficacy [24].…”

Section: Discussionmentioning

confidence: 99%

“…In both the left and right endothelial growth factors, the size of follicles that matured into mature oocytes increased significantly (p = 0.000) on pelvic ultrasonography. Fibroblast Growth Factor (FGF) and (VEGF) were not raised in infertile women before treatment when compared to infertile women before treatment, table (4).…”

Section: The Table (3)mentioning

confidence: 99%

“…AntiMüllerian Hormone -AMH is a glyco-protein that is generated through the granulosa cells of small antral follicles, prenatal and assists in folliculo-genesis guidance (FGG) [4]. It's essential for cell growth and differentiation [5].…”

Section: Introductionmentioning

confidence: 99%

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Study The Pharmacologic Effect Of Both Gonadotropins And Letrozole On The Level Of Serum Glycoproteins (Inhibin B, Amh, And Hrg) In Infertile Women And Their Effect On Stimulating Ovulation

2022

pnr

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Objective: To see how letrozole and gonadotropin alter the levels of serum glycoproteins (HRG, AMH, and Inhibin B) .Methods: As a control group, 33 infertile women and 22 healthy (fertile women) were recruited from an outpatient women's clinic (OWC). They are between the ages of ( 50) and ( 44). HRG, inhibin B, and AMH glycoproteins were evaluated using the ELISA technique.Results: According to a research that evaluated the blood levels of inhibin B, AMH, and HRG in infertile and healthy women, Infertile women's serum inhibin B levels are substantially lower than healthy women's (p = 0.05). Despite the fact that HRG and AMH concentrations were not significantly different (p > 0.05), the quantity and size of oocytes increased significantly (p = 0.000) in both the right and left ovarian infertile women after therapy as compared to the infertile ladies who were infertile before therapy.Conclusion: Letrozole and gonadotropin medicines have an effect on HRG and AMH levels in infertile women after treatment.

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Section: Discussionmentioning

confidence: 99%

Section: The Table (3)mentioning

confidence: 99%

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Study The Pharmacologic Effect Of Both Gonadotropins And Letrozole On The Level Of Serum Glycoproteins (Inhibin B, Amh, And Hrg) In Infertile Women And Their Effect On Stimulating Ovulation

2022

pnr

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“…As mentioned previously, AMH research in adolescents predominantly focuses on populations with preexisting conditions related to sexual maturity, hormones and fertility [10][11][12]14,20,25,26 and, though limited, research on AMH and growth and maturation has typically evaluated sexual characteristics [27][28][29] .…”

Section: Longitudinal Relationships Between Amh Levels and Age Parame...mentioning

confidence: 99%

Anti-Müllerian hormone levels are associated with skeletal maturity in adolescent girls in the Fels Longitudinal Study

Ford,

Choh,

Gonzalez

et al. 2023

Preprint

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The role of anti-Müllerian hormone (AMH), a potential marker of the hypothalamic-pituitary-ovarian axis, is not well established in adolescent females. Most studies use secondary sexual characteristics or chronological age as predictors for AMH. Skeletal maturity, an indicator of bone development, has not been examined to predict AMH. This study sought to examine patterns of change in AMH in relation to skeletal maturity. Demographics, anthropometry, hand-wrist radiographs, and cardiometabolic risk factors from 88 females (212 observations), between the ages of 8 to 18 years from the Fels Longitudinal Study were used in this study. AMH was analyzed using ELISA from stored frozen serum samples. Generalized linear mixed effect modeling was used. In the stepwise regression models, log-transformed AMH (AMHlog) was regressed on relative skeletal age as the skeletal maturity indicator (calculated as chronological age minus skeletal age) and adjusted for chronological age, adiposity, and cardiometabolic risk factors. Skeletal maturity significantly predicted lower AMHlog (β= -0.073, SE=0.032, p=0.023). Glucose was significantly associated with decreases in AMHlog (β= -0.008, SE=0.004, p=0.044). Chronological age modeled as a cubic function was not significant. AMH and skeletal maturity may provide correlated information on growth and pubertal status in adolescent females.

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“…У женщин АМГ продуцируется непосредственно гранулезными клетками [4] преантральных и ранних антральных фолликулов диаметром до 6 мм и служит отрицательным аутокринным и паракринным регулятором фолликулогенеза. АМГ ингибирует дифференцировку покоящихся примордиальных фолликулов и ослабляет чувствительность растущих фолликулов к ФСГ, в частности, ингибируя активность ароматазы [5], однако точные механизмы данных процессов остаются в значительной степени неизвестными [6].…”

Section: Introductionunclassified

The role of anti-Mullerian hormone in the context of modern pathogenetic approaches to the treatment of endometriosis (literature review)

Buralkina,

Chekeneva,

Pavlovich

et al. 2023

Medicinskij sovet

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Anti-Mullerian hormone (AMH) is well known as one of the key factors in reproductive development and the formation of sexual characteristics in the embryonic period in both sexes. In women, AMH is produced by granulosa cells of the preantral and early antral follicles of the ovaries and is a key biochemical marker of ovarian reserve. Recently, the role of AMH and its transmembrane receptor AMHRII as possible pathogenetic links in a number of gynecological diseases has been actively studied. The ability of AMH to cause regression of the Müllerian duct in male embryos suggests its inhibitory role for a number of benign and malignant gynecological tumors, as well as endometriosis. In this connection, active scientific research in this direction is currently underway. A number of studies have shown that AMH causes apoptosis of human endometrial stromal cells and endometriosis cells in vitro, and is also involved in the development of autophagy processes in endometriosis. The above studies demonstrate the important role of AMH in cell apoptosis in endometriosis, and indicate its therapeutic potential for a wide range of gynecological diseases. It is important to note that AMH, as a representativemember of the TGF-β superfamily, has high affinity and specificity for the AMHRII receptor, which. This fact makes further study of the function of AMH and AMHRII relevant both for assessing their effectinfluence on the processes of folliculogenesis, and reproductive aging processes, and for developing new targeting targeted therapy strategies therapy for a wide range of gynecological diseases, including endometriosis.

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Anti-Müllerian hormone: a critical factor for female fertility and reproductive health

Cited by 5 publications

References 26 publications

Study The Pharmacologic Effect Of Both Gonadotropins And Letrozole On The Level Of Serum Glycoproteins (Inhibin B, Amh, And Hrg) In Infertile Women And Their Effect On Stimulating Ovulation

Study The Pharmacologic Effect Of Both Gonadotropins And Letrozole On The Level Of Serum Glycoproteins (Inhibin B, Amh, And Hrg) In Infertile Women And Their Effect On Stimulating Ovulation

Anti-Müllerian hormone levels are associated with skeletal maturity in adolescent girls in the Fels Longitudinal Study

The role of anti-Mullerian hormone in the context of modern pathogenetic approaches to the treatment of endometriosis (literature review)

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