Anti-microbiological and Anti-infective Activities of Silver

Griffith, May; Udekwu, Klas I.; Gkotzis, Spyridon; Mah, Thien-Fah; Alarcon, Emilio I.

doi:10.1007/978-3-319-11262-6_6

Cited by 23 publications

(24 citation statements)

References 70 publications

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“…Silver has been used since ancient Roman times and now used in biomedical devices (de Alwis Weerasekera et al, 2015). Silver NP-based ointments/creams are perhaps the most widely used primarily because of the antimicrobial properties of nanocrystalline silver (Griffith et al, 2015). Silver NPs or nanocrystals in a topical gel have been used for moist wound care and promote cosmetic healing, have effective antibacterial properties, and play a role in cytokine modulation and suppress inflammation (Tian et al, 2007; Jain et al, 2009; Rigo et al, 2013).…”

Section: Nanoparticle-based Wound Therapiesmentioning

confidence: 99%

Biomaterials and Nanotherapeutics for Enhancing Skin Wound Healing

Baker

2016

Front. Bioeng. Biotechnol.

249

196

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Wound healing is an intricate process that requires complex coordination between many cell types and an appropriate extracellular microenvironment. Chronic wounds often suffer from high protease activity, persistent infection, excess inflammation, and hypoxia. While there has been intense investigation to find new methods to improve cutaneous wound care, the management of chronic wounds, burns, and skin wound infection remain challenging clinical problems. Ideally, advanced wound dressings can provide enhanced healing and bridge the gaps in the healing processes that prevent chronic wounds from healing. These technologies have great potential for improving outcomes in patients with poorly healing wounds but face significant barriers in addressing the heterogeneity and clinical complexity of chronic or severe wounds. Active wound dressings aim to enhance the natural healing process and work to counter many aspects that plague poorly healing wounds, including excessive inflammation, ischemia, scarring, and wound infection. This review paper discusses recent advances in the development of biomaterials and nanoparticle therapeutics to enhance wound healing. In particular, this review focuses on the novel cutaneous wound treatments that have undergone significant preclinical development or are currently used in clinical practice.

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Section: Nanoparticle-based Wound Therapiesmentioning

confidence: 99%

Biomaterials and Nanotherapeutics for Enhancing Skin Wound Healing

Baker

2016

Front. Bioeng. Biotechnol.

249

196

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“…[54][55][56][57] Ag NPs wire explosion, polyols, micelle-based and biological synthesis. [61][62][63][64][65][66][67] As mentioned above, though silver has strong anti-microbial properties, [68][69] it can have an adverse effect on the human body. [70][71] Silver has an 'oligo-dynamic' effect, i.e., it is able to exert a bactericidal effect on the containers that are coated with it, e.g., silver pots that store water.…”

Section: Inorganic Antimicrobial Agentsmentioning

confidence: 97%

“…They have an affinity for the nucleophile amino acid residues on the proteins and can even react with the sulfhydryl, imidazole, amino, carboxy and the phosphate residues in the proteins and the various cellular components. 69,[76][77] Silver also combines with an oxygen molecule and reacts with the sulfhydryl groups, to form R-S-S-R bonds, thus hindering respiratory activities and resulting in cell death. [78][79] Silver NPs inhibit many oxidative enzymes, including alcohol dehydrogenase, and inhibit the uptake of succinate by the membrane vesicles.…”

Section: Inorganic Antimicrobial Agentsmentioning

confidence: 99%

“…They cause oxidative DNA damage and interfere with DNA replication processes, [81][82] mitochondrial functioning and destroy the cellular membrane structure. 69,[83][84][85][86] Ionic forms of silver or Ag NPs can interact with the bacterial cell wall by electrostatic interactions and form small pits on the cell wall. 87 Generally, low concentrations of Ag + can lead to loss of protons from the cell membrane, resulting in the destruction of cellular structure.…”

Section: Inorganic Antimicrobial Agentsmentioning

confidence: 99%

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Antimicrobial Treatment of Different Metal Oxide Nanoparticles: A Critical Review

Parham

Wicaksono

Bagherbaigi

et al. 2016

J Chinese Chemical Soc

126

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Many nanomaterials can be used as metal oxides (Ti, Ag, Zn, Cu, Mg, Ca, Ce, Yt, Al). Metal oxide nanoparticles have strong antimicrobial properties. The oxides that play a large role as antimicrobial agents can be divided into two major groups based on their mechanism of action i.e., those that involve oxidation and those that inhibit the production of Reactive Oxygen Species (ROS). Previous studies have shown that, toxic metals like silver and titanium, and their metals oxides, employ the ROS-mediated mechanism that leads to oxidative stress-related cytotoxicity, cancer, and heart diseases. Oxidative stress further leads to increased ROS production and also delays the cellular processes involved in wound healing. Other metal oxide nanoparticles, like Y 2 O 3 , CeO 2 and Al 2 O 3 act as free radical scavengers. Out of these, aluminium oxide nanoparticles are more effective antimicrobial agents, than the other metal oxide nanoparticles. A combination of Al 2 O 3 and other antimicrobial agents such as TiO 2 may act as ideal antimicrobial agents, along with possessing free radical scavenging activity. This critical review aims to study the antimicrobial properties of different metal oxide nanoparticles and the mechanism of action involved, besides comparing their efficacy to eliminate bacteria.

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“…During recent decades, however, the alarming rise in the number of antibiotic and multidrug resistant, a.k.a. super-bugs, bacteria strains (Tenover, 2006), has triggered the search for new, more effective, therapies for bacterial infection control, such as nanoparticulated silver (AgNP) (Varner et al, 2010;Rai et al, 2012;Griffith et al, 2015). Despite some studies suggesting that AgNP can present health risks similar to those of ionic silver (Eckhardt et al, 2013;De Alwis Weerasekera et al, 2015), growing evidence indicates otherwise (Asharani et al, 2008;Travan et al, 2009;Moulton et al, 2010;Trickler et al, 2010;Bouwmeester et al, 2011;Stoehr et al, 2011;Alarcon et al, 2012Alarcon et al, , 2013Lu et al, 2012b;Simpson et al, 2013;Vignoni et al, 2014).…”

Section: Nanomaterials As Therapeutic Agents For Skin Regenerationmentioning

confidence: 99%

Nano-Engineered Biomaterials for Tissue Regeneration: What Has Been Achieved So Far?

et al. 2016

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Nanomaterials have attracted the interest of tissue engineers for the last two decades. Their unique properties make them promising for de novo fabrication of bio-inspired hybrid/composite materials with improved regenerative properties, including, for example, the capacity for electric conductivity and the provision of antimicrobial properties. However, to this day, the use of such materials in medical applications is rather limited and most of the studies have only reached the archetypical proof-of-concept stage. Herein, we present a review on the use of nanomaterials in tissue engineering for regenerative therapies of heart, skin, eye, skeletal muscle, and nervous system. The advantages and limitations of nano-engineering materials are presented in this review alongside with the future challenges and milestones nanotechnology must overcome to make an impact in biomedical applications.

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Anti-microbiological and Anti-infective Activities of Silver

Cited by 23 publications

References 70 publications

Biomaterials and Nanotherapeutics for Enhancing Skin Wound Healing

Biomaterials and Nanotherapeutics for Enhancing Skin Wound Healing

Antimicrobial Treatment of Different Metal Oxide Nanoparticles: A Critical Review

Nano-Engineered Biomaterials for Tissue Regeneration: What Has Been Achieved So Far?

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