Anti-Melanogenic and Anti-Inflammatory Activities of Triterpenoids from Jatropha macrantha

Ticona, Luis Apaza; Serban, Andreea Madalina; Madorrán, M.J. Puerto; Fernández-Grifol, María; Sánchez, Ángel Rumbero

doi:10.1007/s43450-021-00131-y

Cited by 6 publications

(2 citation statements)

References 33 publications

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“…Swartzia polyphylla (Cumaceba) extract is used in the treatment of arthritis, cooling, muscle pain, joint inflammation, tuberculosis and upper respiratory infections, as well as a virility fortifier, female hormonal tonic and aphrodisiac, among others (Roumy et al, 2020). Jatropha macrantha (Male Huanarpo) extract is used mainly as an aphrodisiac and in the treatment of skin ulcers (Apaza Ticona et al, 2021;Tinco-Jayo et al, 2022). In this study, the prebiotic effect of these extracts was determined using the atomized mixture of Swartzia polyphylla, Maytenus macrocarpa and Jatropha macrantha extracts on the viability of Lactobacillus plantarum and L. acidophilus.…”

Section: Introductionmentioning

confidence: 99%

Potencial prebiótico in vitro del extracto atomizado de Swartzia polyphylla, Maytenus macrocarpa y Jatropha macrantha sobre Lactobacillus plantarum y Lactobacillus acidophilus

HUAPAYA¹,

Zavaleta²,

RAMIREZ³

et al. 2022

Manglar

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The combination of prebiotics stimulates the growth of intestinal biota. Atomized extracts containing phenolic compounds promote the proliferation of some lactic acid bacteria (LAB). The objective of this research was to determine in vitro prebiotic potential of the atomized extract (AE) of Swartzia polyphylla (Cumaceba), Maytenus macrocarpa (Chuchuwasi) and Jatropha macrantha (Huanarpo male) on L. plantarum ATCC 14917 and L. acidophilus ATCC 4356. To do this, the bacteria were grown in the De Man Rogosa Sharp (MRS) media containing 1 and 2% (w/v) of AE in anaerobiosis at 37 °C for 48 h. Then, the cell count was performed in MRS agar, and the kinetic parameters and pH were measured. In addition, the resistance of these bacteria to simulated gastrointestinal conditions was assessed. The AE stimulated bacterial growth by maintaining a cell concentration greater than 10 x 106 for 48 h. The growth rates were 0.635 and 0.656 h-1 for L. plantarum as well as 0.391 and 0.516 h-1 for L. acidophilus in the MRS media containing 1% and 2% (w/v) of AE, respectively. The protective effect of the AE under simulated gastrointestinal conditions for L. plantarum and L. acidophilus was significant at pH 7.0 and 2.0, respectively. Overall, the AE presented prebiotic potential in vitro.

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Section: Introductionmentioning

confidence: 99%

Potencial prebiótico in vitro del extracto atomizado de Swartzia polyphylla, Maytenus macrocarpa y Jatropha macrantha sobre Lactobacillus plantarum y Lactobacillus acidophilus

HUAPAYA¹,

Zavaleta²,

RAMIREZ³

et al. 2022

Manglar

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“…is also known as “huanarpo macho” in Peru and considered a medicinal plant potentially as aphrodisiac [ 16 ]. Other studies refer a bronchodilator effect [ 17 ], antimelanogenic, antiinflammatory [ 18 ], inhibitor of nuclear factor–ĸB and hypoxia inducible factor 1 (HIF-1) in tumor cells [ 19 ], modulatory of estradiol, progesterone and testosterone [ 20 ], antioxidant and inhibitory of aldose reductase [ 21 ]. Otherwise, a new tendency in the consumption of natural products, which includes dietary supplements, herbal medicines or medicinal plants are increasingly for treatment of ED, particularly sold as over-the-counter products [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Screening by LC-ESI-MS/MS and Effect of the Ethyl Acetate Fraction from Leaves and Stems of Jatropha macrantha Müll Arg. on Ketamine-Induced Erectile Dysfunction in Rats

et al. 2021

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Jatropha macrantha Müll Arg. L is also known as “huanarpo macho” and used in the Peruvian traditional medicine as an aphrodisiac and erectile dysfunction (ED). The aim of this study was to determine the phytochemical constituents in leaves and stems ethyl acetate fraction (LEAF and SEAF) of J. macrantha and to compare the antioxidant activity and the ameliorative effect on ketamine-induced erectile dysfunction in rats. The phytochemical constituents were determined by LC-ESI-MS/MS, the total phenolic compounds and total flavonoids (TPC and TF) by Folin-Ciocalteu and aluminum chloride, respectively. The antioxidant activity was determined by DPPH, ABTS, and FRAP assays. Experimental groups were divided as follows: I: negative control; II: positive control (ketamine at 50 mg/ kg/d); III: sildenafil 5 mg/kg; IV, V, VI: LEAF at 25, 50 and 100 mg/kg, respectively, and VII, VIII, IX: SEAF at 25, 50, and 100 mg/kg, respectively. The phytochemical analysis revealed the presence mainly of coumarins, flavonoids, phenolic acids, and terpenes. TPC of LEAF and SEAF were 359 ± 5.21 mg GAE/g and 306 ± 1.93 mg GAE/g, respectively; TF in LEAF and SEAF were 23.7 ± 0.80 mg EQ/g, and 101 ± 1.42 mg EQ/g, respectively. The DPPH, ABTS, FRAP in SEAF were 647 ± 3.27; 668 ± 2.30; and 575 ± 2.86 μmol TE/g, respectively, whilst LEAF showed 796 ± 3.15; 679 ± 0.85; and 806 ± 3.42 μmol TE/g, respectively. Regarding sexual behavior, LEAF showed a better effect in mount frequency, intromission frequency, ejaculation frequency, mount latency, intromission latency, ejaculatory latency, and post ejaculatory latency than SEAF. As conclusion, LEAF of J. macrantha at 50 mg/kg showed a better effect on sexual behavior in male rats with erectile dysfunction than SEAF but not higher than sildenafil.

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LC/HRESI-MS/MS screening, phytochemical characterization, and in vitro antioxidant and cytotoxic potential of Jatropha integerrima Jacq. extracts

Marzouk,

Khalifa,

Ahmed

et al. 2023

Bioorganic Chemistry

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Anti-Melanogenic and Anti-Inflammatory Activities of Triterpenoids from Jatropha macrantha

Cited by 6 publications

References 33 publications

Potencial prebiótico in vitro del extracto atomizado de Swartzia polyphylla, Maytenus macrocarpa y Jatropha macrantha sobre Lactobacillus plantarum y Lactobacillus acidophilus

Potencial prebiótico in vitro del extracto atomizado de Swartzia polyphylla, Maytenus macrocarpa y Jatropha macrantha sobre Lactobacillus plantarum y Lactobacillus acidophilus

Phytochemical Screening by LC-ESI-MS/MS and Effect of the Ethyl Acetate Fraction from Leaves and Stems of Jatropha macrantha Müll Arg. on Ketamine-Induced Erectile Dysfunction in Rats

LC/HRESI-MS/MS screening, phytochemical characterization, and in vitro antioxidant and cytotoxic potential of Jatropha integerrima Jacq. extracts

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