Anti-inflammatory properties of α- and γ-tocopherol

Reiter, Elke; Jiang, Qing; Christen, Stephan

doi:10.1016/j.mam.2007.01.003

Cited by 244 publications

(168 citation statements)

References 91 publications

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“…The absence of a general association with antioxidants such as vitamin C and carotenoids and the associations with immune and lung function suggest that biological properties of vitamin E independent of antioxidant activity may be relevant (102) . Vitamin E and flavonoids have been reported to have complex effects on immunological and inflammatory pathways that may be relevant to the development of asthma and allergic disease (102)(103)(104) . The anti-inflammatory effects of vitamin E are believed to be mediated by the inhibition of protein kinase B and C activity, which may inhibit the activation and DNA binding of the transcription factor NF-kB, with consequent effects on the regulation of inflammatory cytokines, adhesion molecules and other proinflammatory molecules.…”

Section: Maternal Antioxidant Intake During Pregnancy and Childhood Amentioning

confidence: 99%

Session 1: Allergic disease Nutrition as a potential determinant of asthma

Devereux

2009

Proc. Nutr. Soc.

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Asthma is characterised by chronic lung airway inflammation, increased airway responsiveness and variable airflow obstruction. In Westernised countries asthma is a public health concern because of its prevalence, associated ill health and high societal and healthcare costs. In recent decades there has been a marked increase in asthma prevalence, particularly in Westernised countries. It has been proposed that changing diet has contributed to the increase in asthma. Several dietary hypotheses exist; the first relates the increase in asthma to declining dietary antioxidant intake, the second to decreased intake of long-chainn-3 PUFA and increasing intake ofn-6 PUFA. Vitamin D supplementation and deficiency have also been hypothesised to have contributed to the increase in asthma. Observational studies have reported associations between asthma and dietary antioxidants (vitamin E, vitamin C, carotenoids, Se, flavonoids, fruit), lipids (PUFA, butter, margarine, fish) and vitamin D. However, supplementing the diets of adults with asthma with antioxidants and lipids has minimal, if any, clinical benefit. There is growing interest in the possibility that childhood asthma is influenced by maternal diet during pregnancy, with studies highlighting associations between childhood asthma and maternal intake of some nutrients (vitamin E, vitamin D, Se, PUFA) during pregnancy. It has been suggested that maternal diet during pregnancy influences fetal airway and/or immune development. Further intervention studies are needed to establish whether modification of maternal nutrient intake during pregnancy can be used as a healthy low-cost public health measure to reduce the prevalence of childhood asthma.

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Section: Maternal Antioxidant Intake During Pregnancy and Childhood Amentioning

confidence: 99%

Session 1: Allergic disease Nutrition as a potential determinant of asthma

Devereux

2009

Proc. Nutr. Soc.

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“…Vitamin E (-tocopherol) is another phenol having anti-inflammatory action (Tahan et al 2011, Reiter et al, 2007. Its structure is close of phenolic antioxidants.…”

Section: R3mentioning

confidence: 99%

Comparison of stabilization by Vitamin E and 2,6-di-tert-butylphenols during polyethylene radio-thermal-oxidation

Richaud

2014

Radiation Physics and Chemistry

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is an open access repository that collects the work of Arts et Métiers ParisTech researchers and makes it freely available over the web where possible. ABSTRACT This paper reports a compilation of data for PE + vitamin E and 2,6-di-tert-butyl phenols oxidation in radio-thermal ageing. Data unambiguously show that vitamin E react with P° and POO° whereas 2,6-di-tert-butyl phenols only react with POO°. Kinetic parameters of the stabilization reactions for both kinds of antioxidants were tentatively extracted from phenol depletion curves, and discussed regarding the structure of the stabilizer. They were also used for completing an existing kinetic model used for predicting the stabilization by antioxidants. This one permits to compare the efficiency of stabilizer with dose rate or sample thickness.2

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“…PPARc activity is influenced by vitamin E [18] with possible role in the control of inflammatory and cell survival pathways. Also the effect that vitamin E can have on COX-2 activity could sustain PPARc-dependent signals through a lowered generation of cell prostaglandin E2a (PGE-2a), which is a physiological PPARc inhibitor [19].…”

Section: Cellular Effects and Signaling Of Vitamin Ementioning

confidence: 99%

“…The formation of a complex and a possible competitive inhibition by a-tocopherol were described for phospholipase A2 isoenzymes [24,25], and other mechanisms that include the control of substrate and cofactor availability could be responsible of the modulation of COX-2, 5-lipoxygenase and cPLA 2 (reviewed in [19,26]). The c form of vitamin E and more recently long chain metabolites were confirmed to be the most efficient COX-2 inhibitors in vitro and in vivo [5].…”

Section: Cellular Effects and Signaling Of Vitamin Ementioning

confidence: 99%

Present trends in vitamin E research

Galli

Azzi

2010

BioFactors

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Abstract.Nearly after one century of research and thousands of publications, the physiological function(s) of vitamin E remain unclear. Available evidence suggests a role in cell homeostasis that occurs through the modulation of specific signaling pathways and genes involved in proliferative, metabolic, inflammatory, and antioxidant pathways. Vitamin E presence in the human body is under close metabolic control so that only a-tocopherol and, to a lower extent, c-tocopherol are retained and delivered to tissues. Other vitamin E forms that are not retained in the body in significant amounts, exhibit responses in vitro that are different form those of a-tocopherol and may include tumor cell specific toxicity and apoptosis. These responses provide a therapeutic potential for these minor forms, either as such or metabolically modified, to produce bioactive metabolites. These cellular effects go beyond the properties of lipophilic antioxidant attributed to a-tocopherol particularly investigated for its alleged protective role in atherosclerosis or other oxidative stress conditions. Understanding signaling and gene expression effects of vitamin E could help assign a physiological role to this vitamin, which will be discussed in this review. Besides vitamin E signaling, attention will be given to tocotrienols as one of the emerging topics in vitamin E research and a critical re-examination of the most recent clinical trials will be provided together with the potential use of vitamin E in disease prevention and therapy.

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Anti-inflammatory properties of α- and γ-tocopherol

Cited by 244 publications

References 91 publications

Session 1: Allergic disease Nutrition as a potential determinant of asthma

Session 1: Allergic disease Nutrition as a potential determinant of asthma

Comparison of stabilization by Vitamin E and 2,6-di-tert-butylphenols during polyethylene radio-thermal-oxidation

Present trends in vitamin E research

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