Anti-Inflammatory Properties of a Lipid Fraction Obtained from Sideritis javalambrensis.

Godoy, Antonio; Herrero, Beatriz de las Heras; Vivas, J. M.; Villar, A.

doi:10.1248/bpb.23.1193

Cited by 19 publications

(21 citation statements)

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“…From these data and previous investigations 3) on Sideritis plant species, we can suggest that different kind of lipids (glycerolipids, sterols) contribute to the anti-inflammatory profile of this genus, although the spectra of action of these compounds is different. …”

Section: Resultssupporting

confidence: 66%

“…1,2) We have recently reported the anti-inflammatory properties of a lipid fraction obtained from Sideritis javalambrensis and those of the diterpenoid (ent-13(16),14-labdadiene-6a,8a,18triol-andalusol-) isolated from the acetone extract of Sideritis foetens, an endemic plant of Southern Spain. 3,4,5) Inflammation is normally a localized protective response which serves to destroy, dilute, or wall-off both the injurious agent and the injured tissue. The inflammatory response is coordinated by cells such as macrophages, lymphocytes, leukocytes and mast cells.…”

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confidence: 99%

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Anti-Inflammatory and Immunomodulating Properties of a Sterol Fraction from Sideritis foetens Clem.

Navarro

Heras

Villar

2001

Biological & Pharmaceutical Bulletin

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124

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Interest in the phytochemical study of species of the Sideritis genus (Lamiaceae) has been stimulated by their pharmacological activity and their wide range of medicinal folk uses in Spain such as vulnerary, anti-infectious, anti-inflammatory, anti-rheumatic and anti-ulcerous applications. Various flavonoids and terpenoids have been isolated from this genus. 1,2) We have recently reported the anti-inflammatory properties of a lipid fraction obtained from Sideritis javalambrensis and those of the diterpenoid (ent-13(16),14-labdadiene-6a,8a,18triol-andalusol-) isolated from the acetone extract of Sideritis foetens, an endemic plant of Southern Spain. 3,4,5) Inflammation is normally a localized protective response which serves to destroy, dilute, or wall-off both the injurious agent and the injured tissue. The inflammatory response is coordinated by cells such as macrophages, lymphocytes, leukocytes and mast cells. A large number of mediators produced by these cells play a key role, for example, arachidonic acid metabolites such as prostaglandins and leukotrienes, reactive oxygen species, hydrolytic enzymes, histamine, nitric oxide, cytokines, etc. [6][7][8] Acute inflammation is associated with a rapid, early infiltration of polymorphonuclear leukocytes and increased vascular permeability at the site of injury.In this paper, we have evaluated the in vivo anti-inflammatory properties of a sterol fraction obtained from S. foetens on different inflammatory responses in mice. In addition, the interaction of this fraction with the functional properties of leukocytes and mast cells was analyzed in vitro. Immunomodulating activity through interaction with complement activation was also investigated. MATERIALS AND METHODS Plant MaterialThe aerial parts of Sideritis foetens were collected in Sierra de Gádor, Almería province (Spain). A voucher specimen has been deposited in the Department of Botany, Faculty of Pharmacy, Complutense University, Madrid (Spain). Extraction and IdentificationThe carrageenan-induced mouse paw oedema model was used for a bioassay guidedfractionation based on the anti-inflammatory activity.Dried aerial parts of Sideritis foetens (3 kg) were macerated with 99.5% acetone (12 l) at room temperature. The acetone extract was evaporated in vacuo to yield 84.8 g of residue. This extract (11.8 g) was fractionated by flash column chromatography over a silica gel (450 g, 230-400 mesh) column (6ϫ80 cm) using cyclohexane: acetone 70/30 to yield nine fractions. The most active fraction (subfraction B) (1.5 g) was chromatographed over a silica gel column (80 g, 230-400 mesh) using cyclohexane/ethyl acetate 70/30 as solvent, yielding the sterol fraction as white needles (800 mg).Sterol identification was performed by GC analysis [Perkin Elmer Sigma 3B equipped with a SE-30 Sobrechromosob WHP 3/100 column (lenght 2 m, i.d. 0.32 mm). Experimental conditions were: injector temp., 295°C; oven temp., 270°C (isotherm); detection temp., 285°C)]. The relative retention times were compared to standard samples. Campester...

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Section: Resultssupporting

confidence: 66%

mentioning

confidence: 99%

Anti-Inflammatory and Immunomodulating Properties of a Sterol Fraction from Sideritis foetens Clem.

Navarro

Heras

Villar

2001

Biological & Pharmaceutical Bulletin

Self Cite

124

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“…Some plant extracts that have proven eOE ective in in¯ammation or anti-NF-j B activity include the commonly used phytomedicine stinging nettle (Urtica dioica, Urticaceae ; Riehemann et al 1999), Siderites foetens Clemen. (Lamiaceae) (Navarro et al 2001), a commercially obtained extract of Ginkgo biloba (Ginkgoaceae) (Wei et al 1999), Siderites javalambrensis (Godoy et al 2000), Uncaria tomentosa (Cat's claw, Rubiaceae ; SandovalChaco! n et al 1998), Drosera madagascariensis (Droseraceae ; Melzig et al 2001), Tripterygium wilfordii Hook F. (Sylvester et al 2001) and a bio¯avonoid extract from Pinus maritima (Pinaceae) (Cho et al 2000).…”

Section: Other Compounds and Plant Extractsmentioning

confidence: 99%

Natural products as targeted modulators of the nuclear factor-κB pathway

Bremner

Heinrich

2002

Journal of Pharmacy and Pharmacology

286

165

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The use of plant extracts to alleviate in ammatory diseases is centuries old and continues to this day. This review assesses the current understanding of the use of such plants and natural products isolated from them in terms of their action against the ubiquitous transcription factor, nuclear factor kappa B (NF-j B). As an activator of many pro-in ammatory cytokines and in ammatory processes the modulation of the NF-j B transduction pathway is a principal target to alleviate the symptoms of such diseases as arthritis, in ammatory bowel disease and asthma.Two pathways of NF-j B activation will rst be summarised, leading to the IKK (Ij B kinase) complex, that subsequently initiates phosphorylation of the NF-j B inhibitory protein (Ij B).Natural products and some extracts are reviewed and assessed for their activity and potency as NF-j B inhibitors. A large number of compounds are currently known as NF-j B modulators and include the isoprenoids, most notably kaurene diterpenoids and members of the sesquiterpene lactones class, several phenolics including curcumin and avonoids such as silybin. Additional data on cellular toxicity are also highlighted as an exclusion principle for pursuing such compounds in clinical development. In addition, where enough data exists some conclusions on structure-activity relationship are provided.

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“…The plant kingdom is a potential source of terpenoids that act as anti-inflammatory drugs, a vast number of terpenoids have been evaluated as potential anti-inflammatory molecules in vivo animal models and ex vivo cultures of cells compromised in the inflammatory response [18][19][20][21].…”

Section: Discussionmentioning

confidence: 99%

Analysis and retention behaviour in high-performance liquid chromatography of terpenic plant constituents (Sideritis spp.) with pharmacological interest

Gómez-Serranillos

El-Naggar

Villar

et al. 2004

Journal of Chromatography B

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Anti-Inflammatory Properties of a Lipid Fraction Obtained from Sideritis javalambrensis.

Cited by 19 publications

References 0 publications

Anti-Inflammatory and Immunomodulating Properties of a Sterol Fraction from Sideritis foetens Clem.

Anti-Inflammatory and Immunomodulating Properties of a Sterol Fraction from Sideritis foetens Clem.

Natural products as targeted modulators of the nuclear factor-κB pathway

Analysis and retention behaviour in high-performance liquid chromatography of terpenic plant constituents (Sideritis spp.) with pharmacological interest

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