Anti-inflammatory effects of resveratrol in patients with cardiovascular disease: A systematic review and meta-analysis of randomized controlled trials

Teimouri, Maryam; Tabrizi, Masoud Homayouni; Rajabian, Arezoo; Amiri, Hamed; Hosseini, Hossein

doi:10.1016/j.ctim.2022.102863

Cited by 21 publications

(9 citation statements)

References 45 publications

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“…Resveratrol supplementation also improves endothelial function [ 34 ]. In patients with cardiovascular disease, resveratrol significantly decreases serum levels of CRP and TNF-α, demonstrating the anti-inflammatory effects of resveratrol [ 59 ].…”

Section: Potential Mechanismsmentioning

confidence: 99%

Alcohol and the vasculature: a love-hate relationship?

Xia

2023

Pflugers Arch - Eur J Physiol

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Alcohol consumption is a leading risk factor and increases the risk of liver diseases, cancers, tuberculosis, and injuries. The relationship between alcohol use and cardiovascular risk is complex. While it is well established that heavy alcohol use and binge drinking harm cardiovascular health, the effect of light-to-moderate alcohol consumption remains controversial. Observational studies have repeatedly confirmed the U- or J-shaped relationship between alcohol consumption and cardiovascular disease risk, with the lowest risk observed in the light-to-moderate drinking group. However, the protective effect of low-level alcohol has been challenged by recent genetic epidemiological studies with Mendelian randomization. Such studies have their own limitations, and the application of this methodology in studying alcohol has been questioned. Results from the latest Global Burden of Diseases, Injuries, and Risk Factors Study suggest that the impact of alcohol consumption on health depends on the age structure and the distribution of disease burden and underlying causes in a given population. For young adults, even small amounts of alcohol cause heath loss. For older adults facing a high burden of cardiovascular diseases, light-to-moderate alcohol consumption may improve cardiovascular health outcomes. Mechanistically, all types of alcoholic beverages, including wine, spirits, and beer, have been shown to increase the levels of high-density lipoprotein cholesterol and adiponectin, and reduce the level of fibrinogen. Nonalcoholic components of wine, especially polyphenolic compounds like resveratrol, may additionally enhance endothelial nitric oxide production, and provide antioxidant and anti-inflammatory effects.

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Section: Potential Mechanismsmentioning

confidence: 99%

Alcohol and the vasculature: a love-hate relationship?

Xia

2023

Pflugers Arch - Eur J Physiol

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“…32 El RV tiene una rápida metabolización y baja biodisponibilidad. Sin embargo, hay evidencia de que puede ayudar a reducir los efectos neurocognitivos de varias patologías como problemas vasculares, 33 Parkinson 34 o los síntomas de infección por el virus de inmunodeficiencia adquirida. 35 Considerando lo anterior es conveniente continuar con esta línea de investigación, considerando biodisponibilidad del RV, entre las alternativas se encuentran el uso de sustancias análogas (ej.…”

Section: @Revistacyrsunclassified

Efecto de resveratrol sobre los marcadores de estrés oxidante y las funciones cognitivas en un adulto mayor con diabetes mellitus tipo 2. Caso clínico

García-García,

Ruiz-Ramos

2023

CyRS

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Introducción. El resveratrol es un nutracéutico que se encuentra en diversos frutos rojos y en el vino, se ha utilizado como coadyuvante en diversas patologías, ya que puede disminuir el estrés oxidante (EOx) y la inflamación crónica (IC). En este sentido, se ha observado que, tras su administración en animales, disminuye el EOx y mejora la neurogénesis; sin embargo, las evidencias en estudios con humanos son inconsistentes. Por tal motivo, se presenta un caso clínico del efecto del resveratrol sobre los marcadores de estrés oxidante y las funciones cognitivas en un adulto mayor. Caso clínico. Adulta mayor de 63 años de edad, a quien se le administró una dosis diaria de 1000 mg/día de resveratrol durante 12 meses. Se le realizó la evaluación de los marcadores de EOx y funciones cognitivas al inicio y final del tratamiento. Se encontró que los marcadores del sistema antioxidante aumentaron y mejoró en aprendizaje verbal, fluidez verbal, velocidad de procesamiento y memoria de trabajo. Conclusión. Nuestros hallazgos sugieren que el consumo del resveratrol a dosis de 1000mg/día durante 12 meses mejorar el sistema antioxidante y las funciones cognitivas del adulto mayor, sin embargo, es necesario realizar ensayos clínicos aleatorizados para confirmar nuestros resultados.

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“…In particular, experimental results highlight a number of RSV benefits on CM risk and disease (e.g., the improvement of the lipid profile, oxidative stress reduction, the prevention of platelet aggregation and the maintenance of endothelial function through the enhancement of nitric oxide (NO) bioavailability and inhibition of endothelin (ET-1)) [8][9][10][11]. In humans, RSV has been observed to improve endothelial function and inflammatory biomarkers [12,13]. Moreover, data have shown that RSV improves glucose and glycated hemoglobin (HbA1c) and insulin profiles, thus preventing type 2 diabetes (T2D) and its cardiovascular complications.…”

Section: Introductionmentioning

confidence: 99%

Sphingolipid Levels and Signaling via Resveratrol and Antioxidant Actions in Cardiometabolic Risk and Disease

2023

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Resveratrol (RSV) is a phenolic compound with strong antioxidant activity, which is generally associated with the beneficial effects of wine on human health. All resveratrol-mediated benefits exerted on different systems and pathophysiological conditions are possible through resveratrol’s interactions with different biological targets, along with its involvement in several key cellular pathways affecting cardiometabolic (CM) health. With regard to its role in oxidative stress, RSV exerts its antioxidant activity not only as a free radical scavenger but also by increasing the activity of antioxidant enzymes and regulating redox genes, nitric oxide bioavailability and mitochondrial function. Moreover, several studies have demonstrated that some RSV effects are mediated by changes in sphingolipids, a class of biolipids involved in a number of cellular functions (e.g., apoptosis, cell proliferation, oxidative stress and inflammation) that have attracted interest as emerging critical determinants of CM risk and disease. Accordingly, this review aimed to discuss the available data regarding the effects of RSV on sphingolipid metabolism and signaling in CM risk and disease, focusing on oxidative stress/inflammatory-related aspects, and the clinical implications of this relationship.

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Anti-inflammatory effects of resveratrol in patients with cardiovascular disease: A systematic review and meta-analysis of randomized controlled trials

Cited by 21 publications

References 45 publications

Alcohol and the vasculature: a love-hate relationship?

Alcohol and the vasculature: a love-hate relationship?

Efecto de resveratrol sobre los marcadores de estrés oxidante y las funciones cognitivas en un adulto mayor con diabetes mellitus tipo 2. Caso clínico

Sphingolipid Levels and Signaling via Resveratrol and Antioxidant Actions in Cardiometabolic Risk and Disease

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