Anti-inflammatory effects of Lacto-Wolfberry in a mouse model of experimental colitis

Philippe, David; Brahmbhatt, Viral; Foata, Francis; Saudan, Y; Serrant, Patrick; Blum, Stéphanie; Benyacoub, Jalil; Vidal, Karine

doi:10.3748/wjg.v18.i38.5351

Cited by 22 publications

(17 citation statements)

References 37 publications

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“…Lycium barbarum polysaccharides (LBP) protects the small intestinal structure and contributes barrier function in the intestinal damage induced by ischemia reperfusion . A milk‐based Goji preparation exerted protective roles in 2,4,6‐trinitrobenzene sulfonic acid (TNBS)‐induced colitis . Dietary Goji ameliorated IBD symptoms in dextran sulfate sodium (DSS)induced colitis mice accompanied with decreased neutrophil infiltration and suppressed inflammatory responses…”

Section: Introductionmentioning

confidence: 96%

Goji Berry Modulates Gut Microbiota and Alleviates Colitis in IL‐10‐Deficient Mice

Kang

Yang

Zhang

et al. 2018

Molecular Nutrition Food Res

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Scope This study examines the beneficial effects of Goji berry against spontaneous colitis and its prebiotic role in IL‐10‐deficient mice. Methods IL‐10‐deficient mice are assigned to a standard rodent diet (control) or a control diet supplemented with Goji (1% of dry feed weight) for 10 weeks, at which point colonic tissues and fecal contents are collected. Results Goji supplementation decreases colonic pathobiological scores and mRNA expression of Il17a and Tgfb1, while it enhances Muc1 expression and fecal IgA content. Illumina MiSeq sequencing reveals that Goji supplementation increases Actinobacteria phylum, resulting in a bloom of Bifidobacteria in gut microbiota. Additionally, dietary Goji promotes butyrate‐producing bacteria including Lachnospiraceae‐Ruminococcaceae family and Roseburia spp. under Clostridium cluster XIVa. Furthermore, butyrate‐producers Clostridium leptum and its dominant constituent Fecalibacterium prazusnitzii are markedly increased in the Goji group. Moreover, the gene‐encoding butyryl‐coenzyme A CoA transferase, a key enzyme responsible for butyrate synthesis in butyrate‐producing bacteria, is increased sixfold in the fecal samples of Goji group associated with increased fecal butyrate content. Conclusion Data collectively show that dietary Goji results in the blooming of Bifidobacteria and butyrate‐producing bacteria. These bacteria may cross‐feed each other, conferring preventative effects against colitis in IL‐10‐deficient mice.

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Section: Introductionmentioning

confidence: 96%

Goji Berry Modulates Gut Microbiota and Alleviates Colitis in IL‐10‐Deficient Mice

Kang

Yang

Zhang

et al. 2018

Molecular Nutrition Food Res

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“…It also has been documented that WOL polysaccharide fractions can protect against renal damage 29 and reduce immunotoxicity 30 . It has been previously reported that a milk-based WOL preparation can suppress 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis 31 and WOL can suppress dextran sulfate sodium (DSS)induced colitis 32 .…”

Section: Introductionmentioning

confidence: 99%

Integrated omics profiling of dextran sodium sulfate-induced colitic mice supplemented with Wolfberry (Lycium barbarum)

Jia

Lyu

et al. 2020

npj Sci Food

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We used a multi-omics profiling approach to investigate the suppressive effects of 2% Wolfberry (WOL)-enriched diets on dextran sodium sulfate (DSS)-induced colitis in mice. It was observed that in mice fed the WOL diet, the disease activity index, colon shortening, plasma concentrations of matrix metalloproteinase-3 and relative mesenteric fat weight were significantly improved as compared to the DSS group. Results from colon transcriptome and proteome profiles showed that WOL supplementation significantly ameliorated the expression of genes and proteins associated with the integrity of the colonic mucosal wall and colonic inflammation. Based on the hepatic transcriptome, proteome and metabolome data, genes involved in fatty acid metabolism, proteins involved in inflammation and metabolites related to glycolysis were downregulated in WOL mice, leading to lowered inflammation and changes in these molecules may have led to improvement in body weight loss. The integrated nutrigenomic approach thus revealed the molecular mechanisms underlying the ameliorative effect of whole WOL fruit consumption on inflammatory bowel disease.

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“…The mechanism underlying these outcomes remains unclear, due to the complexity of the pharmacology of buprenorphine, as a non‐selective, mixed partial agonist and antagonist to the opioid receptors . Indeed, as a partial agonist of the μ‐opioid receptor, buprenorphine might be expected to ameliorate colitis, since activation of this pathway was beneficial in several models of visceral disease including TNBS, DSS, and ischemia/reperfusion injury . Furthermore, TNBS‐colitis was significantly more lethal in μ‐opioid receptor knock‐out mice, although the histological and morphological inflammatory scores were similar to control mice that received TNBS .…”

Section: Discussionmentioning

confidence: 99%

“…Experiments were conducted on adult male mice weighing 20-25 g (BALB/c) or [30][31][32][33][34][35]. All mice had ad libitum access to food and water and were maintained on a 12:12-hour light:dark cycle at an ambient temperature of 23°C and 25%-40% relative humidity.…”

Section: Animalsmentioning

confidence: 99%

Analgesia and mouse strain influence neuromuscular plasticity in inflamed intestine

Blennerhassett

Lourenssen

Parlow

et al. 2017

Neurogastroenterology Motil

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Anti-inflammatory effects of Lacto-Wolfberry in a mouse model of experimental colitis

Abstract: These results demonstrate the anti-inflammatory properties of LWB and suggest that the underlying mechanism is at least in part due to NF-κB inhibition and improved anti-oxidative capacity.

Cited by 22 publications

References 37 publications

Goji Berry Modulates Gut Microbiota and Alleviates Colitis in IL‐10‐Deficient Mice

Goji Berry Modulates Gut Microbiota and Alleviates Colitis in IL‐10‐Deficient Mice

Integrated omics profiling of dextran sodium sulfate-induced colitic mice supplemented with Wolfberry (Lycium barbarum)

Analgesia and mouse strain influence neuromuscular plasticity in inflamed intestine

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