Anti‐inflammatory effects of exercise: role in diabetes and cardiovascular disease

Abstract

Background Persistent inflammation is involved in the pathogenesis of chronic diseases such as type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD).

The association between anxiety, traumatic stress, and obsessive-compulsive disorders and chronic inflammation: A systematic review and meta-analysis

“…In response to anxiety and fear, the stress response is exacerbated among individuals with these disorders. Notably, these individuals may be more likely to suffer from sleep disturbances, be less likely to engage in exercise, and may utilize alcohol, smoking, food, or drugs in an effort to regulate their anxiety and fear, subsequently putting them at risk for experiencing a number of poor health outcomes over the long term (Michopoulos et al, 2017;Pedersen 2017). Through glucocorticoid insensitivity, HPA dysregulation is theorized to contribute to a state of low-grade inflammation, which might put an individual at risk for negative health consequences (Cohen et al, 2012).…”

Time to challenge the spurious hierarchy of systematic over narrative reviews?

“…Yet leading medical journals regularly publish clinical topic reviews that may lack a focused research question, methods section or statement on how studies were selected and analysed (see for example7, 8, 9). These narrative reviews typically draw on expert opinion by deliberately recruiting leading names in the field (eg “The aim of this Commission is to provide the strongest evidence base through involvement of experts from a wide cross‐section of disciplines…”—page 1953, emphasis added8).…”

Multiplex Quantification Identifies Novel Exercise-regulated Myokines/Cytokines in Plasma and in Glycolytic and Oxidative Skeletal Muscle

“…Conversely, regular exercise confers systemic health benefits (3)(4)(5)(6). The underlying mechanisms responsible for the positive physiological effects of exercise, however, are not well understood (7,8).…”