Anti-inflammatory effect of extract and fractions from the leaves of Byrsonima intermedia A. Juss. in rats

Abstract

BiAE and the individual EtOAc and aqueous fractions of Byrsonima intermedia exhibited chronic and acute anti-inflammatory efficacy in rats, which supports previous claims of its use in traditional medicine.

Dereplication by HPLC‐DAD‐ESI‐MS/MS and Screening for Biological Activities of Byrsonima Species (Malpighiaceae)

“…Moreira et al . () reported that the aqueous extract of B. intermedia leaves exhibited potent anti‐inflammatory activity in animal models by reducing carrageenan‐induced paw edema and granuloma formation in a chronic inflammation model; this activity was attributed to the presence of catechin and flavonoids. Saldanha et al .…”

“…Studies of the genus Byrsonima focus mainly on antimicrobial activity against a range of bacteria, enterobacteria, mycobacteria, protozoa and fungi related to gastrointestinal and skin diseases (Guilhon-Simplicio and Pereira, 2011). In last few years, some studies on other biological properties have been reported in different species and parts of plants, such as antioxidant activity (Gordon et al, 2011;Mariutti et al, 2014;Vargas et al, 2016), central nervous system depressant activity (Herrera-Ruiz et al, 2011), anti-diabetes activity (Perez-Gutierrez et al, 2010, Pérez-Gutierrez andRamirez, 2016), and anti-inflammatory activity (Maldini et al, 2009;Moreira et al, 2011;Saldanha et al, 2016a;Saldanha et al, 2016b).…”

Chemical composition and anti-inflammatory activity of the leaves of Byrsonima verbascifolia

“…Chemical and pharmacological data obtained more recently from the Byrsonima genus can justify its use in folk medicine. Anti-inflammatory [6], gastroprotective, antidiarrheal, antimicrobial [7], and antitubercular activities [8], for instance, have been reported. Phytochemical analyses of the genus showed basically phenolic compounds such as quercetin derivatives and proanthocyanidins [9,10].…”

Yanshu spraying agent, a traditional Chinese medicine, relieves chronic pharyngitis in animals by anti-inflammatory and antibacterial effects

“…The cotton pellet-induced granuloma tissue formation animal model was established as previously described (8), but with minor modifications. Briefly, rats were anesthetized with 350 mg/kg chloral hydrate and two sterilized cotton pellets, that weighed 20 mg each, were implanted subcutaneously on each side of the nape through a small ventral incision in the nape of the rats.…”