Anti-inflammatory, antioxidant and antiangiogenic activities of diosgenin isolated from traditional medicinal plant, <i>Costus speciosus</i> (Koen ex.Retz.) Sm

Selim, Samy; Jaouni, Soad Al

doi:10.1080/14786419.2015.1065493

Cited by 40 publications

(17 citation statements)

References 9 publications

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“…Thus, the formation of new blood vessels in tumors actively supplies the essential nutrients and growth factors that allow tumors to acquire the ability to reject chemotherapeutic drugs and develop chemoresistance [ 27 , 65 , 66 , 67 , 68 ]. Diosgenin is also a potent inhibitor of cancer cell invasion, migration, and tumor-associated angiogenesis [ 27 , 69 ]. He et al, reported that diosgenin inhibited the invasion and migration of triple-negative breast cancer cells and was associated with the concomitant suppression of actin polymerization, phosphorylation of Vav2, and activation of Cdc42 oncoprotein expression.…”

Section: In Vitro Anti-cancer Effects Of Diosgeninmentioning

confidence: 99%

Pro-Apoptotic and Anti-Cancer Properties of Diosgenin: A Comprehensive and Critical Review

et al. 2018

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Novel and alternative options are being adopted to combat the initiation and progression of human cancers. One of the approaches is the use of molecules isolated from traditional medicinal herbs, edible dietary plants and seeds that play a pivotal role in the prevention/treatment of cancer, either alone or in combination with existing chemotherapeutic agents. Compounds that modulate these oncogenic processes are potential candidates for cancer therapy and may eventually make it to clinical applications. Diosgenin is a naturally occurring steroidal sapogenin and is one of the major bioactive compounds found in dietary fenugreek (Trigonella foenum-graecum) seeds. In addition to being a lactation aid, diosgenin has been shown to be hypocholesterolemic, gastro- and hepato-protective, anti-oxidant, anti-inflammatory, anti-diabetic, and anti-cancer. Diosgenin has a unique structural similarity to estrogen. Several preclinical studies have reported on the pro-apoptotic and anti-cancer properties of diosgenin against a variety of cancers, both in in vitro and in vivo. Diosgenin has also been reported to reverse multi-drug resistance in cancer cells and sensitize cancer cells to standard chemotherapy. Remarkably, diosgenin has also been reported to be used by pharmaceutical companies to synthesize steroidal drugs. Several novel diosgenin analogs and nano-formulations have been synthesized with improved anti-cancer efficacy and pharmacokinetic profile. In this review we discuss in detail the multifaceted anti-cancer properties of diosgenin that have found application in pharmaceutical, functional food, and cosmetic industries; and the various intracellular molecular targets modulated by diosgenin that abrogate the oncogenic process.

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Section: In Vitro Anti-cancer Effects Of Diosgeninmentioning

confidence: 99%

Pro-Apoptotic and Anti-Cancer Properties of Diosgenin: A Comprehensive and Critical Review

et al. 2018

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“…In addition to functioning as a lactation aid, this bioactive substance is known for its medicinal qualities, such as antidiabetic and hypocholesterolemic effects, and can be used to treat non-alcoholic fatty liver disease [11]. It also has antioxidant and immunomodulatory properties [11][12][13][14]. Current research on diosgenin has shown that it possesses anticancer properties by inducing differentiation of human erythroleukemia cells through changes in lipoxygenase activities [15], promoting cell cycle arrest [16], and targeting several molecules involved in inhibiting cell proliferation, invasion, migration, angiogenesis, and metastasis of various types of human cancer [16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Induction of G2/M Phase Arrest by Diosgenin via Activation of Chk1 Kinase and Cdc25C Regulatory Pathways to Promote Apoptosis in Human Breast Cancer Cells

Liao

Lin

Shieh

et al. 2019

IJMS

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The anti-tumor activity of diosgenin, a new steroidal constituent present in fenugreek, on two human breast cancer cell lines, MCF-7 and Hs578T, was studied. Diosgenin treatment resulted in cell growth inhibition, cell cycle arrest, and apoptosis in concentration- and time-dependent manners in both cell lines. Western blot analyses of whole cell lysates for cell cycle proteins showed that diosgenin altered phosphorylated cyclin checkpoint1 (p-Chk1Ser345) and cyclin B expression, which resulted in G2/M phase blockade. Mechanistically, Cdc25C-Cdc2 signaling was involved in inactivating Chk1Ser345 by p53-dependence in MCF-7 cells and p21-dependence in Hs578T cells that are p53-deficient. Moreover, diosgenin induced a significant loss of the mitochondrial membrane potential in breast cancer cells, and prominently affected cell death through down-regulation of the anti-apoptotic protein, Bcl-2. This released cytochrome c and activated the caspase signaling cascade. Taken together, these findings reveal that the anti-proliferative activity of diosgenin involves the induction of G2/M phase arrest via modulating the Cdc25C-Cdc2-cyclin B pathway and mitochondria-mediated apoptosis in human breast cancer cell lines. This suggests the potential usefulness of diosgenin in treating breast cancer.

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“…The examination uncovered methanol and luid concentrates at a portion of 200 mg/kg body weight switched diabetes initiated hyperlipidemia.] Alcoholic concentrate of the C. igneus at the portion of 400 mg/kg (p.o) had altogether diminished the degrees of triglycerides, cholesterol, Low-Density Lipoprotein levels in Triton prompted hyperlipidemic rats (Selim and Jaouni, 2016;Shanmugavadivu and Velmurugan, 2018).…”

Section: Resultsmentioning

confidence: 98%

Awareness About Medicinal Uses of Costus Pictus Plant Among Dental Students

Saivarshine

Ganapathy

Sasanka

2020

ijrps

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Costus igneus, typically known as searing costus, is native to South America ordinarily known as the insulin plant. It is typically grown in gardens mostly as a decorative herb in South India and is further out of control in other areas. It is used in India to combat hyperglycaemia and many other diseases. This survey was performed with the purpose of assessing the knowledge and the awareness about the Costus pictus medicinal plant amongst dental students. A cross-sectional survey was performed with a self-administered questionnaire with ten questions circulated among 100 dental students. The questionnaire assessed the awareness about Costus pictus plant, their medicinal uses, antidiabetic activity, antioxidant and antimicrobial activity. The responses were recorded and analysed.93% of the respondents were not aware of medical uses of Costus pictus .95% were not aware of antidiabetic activity of Costus pictus .97 % were not aware of the antioxidant activity of Costus pictus. Again 97% were not aware of the antimicrobial activity of Costus pictus. The knowledge and awareness about the medicinal Costus plant were less among dental students and awareness was created about its medicinal uses.

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Anti-inflammatory, antioxidant and antiangiogenic activities of diosgenin isolated from traditional medicinal plant, Costus speciosus (Koen ex.Retz.) Sm

Cited by 40 publications

References 9 publications

Pro-Apoptotic and Anti-Cancer Properties of Diosgenin: A Comprehensive and Critical Review

Pro-Apoptotic and Anti-Cancer Properties of Diosgenin: A Comprehensive and Critical Review

Induction of G2/M Phase Arrest by Diosgenin via Activation of Chk1 Kinase and Cdc25C Regulatory Pathways to Promote Apoptosis in Human Breast Cancer Cells

Awareness About Medicinal Uses of Costus Pictus Plant Among Dental Students

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