Anti-inflammatory and antiresorptive effects of Calendula officinalis on inflammatory bone loss in rats

Alexandre, Joanna Trycia Magalhães; Sousa, Luzia Hermínia Teixeira; Lisboa, Mário Roberto Pontes; Furlaneto, Flávia Aparecida Chaves; Val, Danielle Rocha do; Marques, Mirna; Vasconcelos, Hellíada C.; Melo, Iracema Matos de; Leitão, Renata F. C.; Brito, Gerly Anne Castro; Góes, Paula

doi:10.1007/s00784-017-2308-7

Cited by 18 publications

(10 citation statements)

References 35 publications

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“…floribundum increased both markers for oxidative stress. These data are in accordance with previous results of our group showing the antioxidant effect of natural extracts from Stemodia maritima L. and Calendula offinalis [24], [31]…”

Section: Discussionsupporting

confidence: 93%

Protective effect of Platymiscium floribundum Vog. in tree extract on periodontitis inflammation in rats

et al. 2019

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Periodontitis is an immuno-inflammatory disease, which can lead to tooth loss. This study aimed to investigate the efficacy of Platymiscium floribundum Vog., a Brazilian tree which has been used in folk medicine as an anti-inflammatory agent, in a pre-clinical trial of periodontitis in rats. Periodontitis was induced by placing a sterilized nylon (3.0) thread ligature around the cervix of the second left upper molar of the rats, which received (per os) P. floribundum extract (0.1, 1 or 10 mg/kg) or vehicle 1h before periodontitis-challenge and once daily during 11 days. Treatment with P. floribundum (10mg/kg) decreased alveolar bone loss, MPO activity nitrite/nitrate levels, oxidative stress, TNF-α, IL1-β, IL-8/CINC-1, and PGE2 gingival levels, and transcription of TNF-α, IL1-β, COX-2, iNOS, RANK, and RANKL genes, while elevated both BALP serum levels and IL-10 gingival levels. The animals did not show signs of toxicity throughout the experimental course. These findings show that P. floribundum has anti-inflammatory and anti-resorptive properties in a pre-clinical trial of periodontitis, representing an interesting biotechnological tool.

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Section: Discussionsupporting

confidence: 93%

Protective effect of Platymiscium floribundum Vog. in tree extract on periodontitis inflammation in rats

et al. 2019

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“…Calendula officinalis is a plant of the genus Calendula of the Asteraceae family . It is also known by the popular name “pot marigold”.…”

Section: Natural Productsmentioning

confidence: 99%

“…Its yellow to orange flowers have been used in Europe for centuries for medicinal purposes in various applications such as infusions, tinctures, liquid extracts, creams, or ointments . Crude extracts of the plant contain polysaccharides, otenoids, lutein, lycopene, rutin, ubiquinone, xanthophylls, flavonoids, triterpene alcohols, phenol acids, tannins, glycosides, sterols, carotenoids, and saponisides . Quercetin and triterpenoid are considered the most important molecules because they possess anti‐inflammatory and antioxidant properties .…”

Section: Natural Productsmentioning

confidence: 99%

Novel natural product‐based oral topical rinses and toothpastes to prevent periodontal diseases

Laleman

Teughels

2020

Periodontology 2000

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There is increasing public interest in natural or herbal‐based healthcare products. This trend is not only visible in supermarkets and dental practices, but also in the scientific world. An improving number of clinical trials are being conducted to validate the claims made about these products in regards to periodontal health. Among single component preparations, Aloe vera and green tea are the most studied natural ingredients. Concerning polyherbal mixtures, triphala has garnered great interest. The effects of these natural products on periodontal health is encouraging, with almost all studies showing an inhibitory effect on plaque accumulation and an improvement in gingival health. However, more studies are needed to be able to design clinical guidelines to guide the use of these natural products in periodontal practice. For most of these products, few studies are available and, moreover, the available studies are limited in duration, the number of participants, and the specific composition of the natural product is often not described in detail.

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“…A calêndula é utilizada na Odontologia para tratamento de estomatites aftosas, como irrigantes no tratamento endodôntico e após exodontias, pela ação antimicrobiana, anti-inflamatória, analgésica, antiedematosa, por promover hemostasia, antirreabsortivos e auxiliar na cicatrização, devido ao efeito colagenogênico e no metabolismo ósseo, preservando o osso alveolar (Alexandre et al, 2018;Bohneberger et al, 2019;Faria et al, 2011;Gupta et al, 2020;Mahyari et al, 2016;Nuñez et al, 2021;Parente et al, 2009;Uribe-Fentanes et al, 2018).…”

Section: Introductionunclassified

Avaliação da toxicidade de diferentes concentrações de tinturas de malva e calêndula através do bioensaio com Artemia salina

Tchemra¹,

Pontes²,

Melo³

et al. 2022

RSD

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O objetivo foi avaliar a toxicidade das tinturas de malva 10% (Malva sylvestris) e calêndula 10% (Calendula officinalis), através do bioensaio com Artemia salina. Os náuplios foram obtidos e transferidos para tubos de ensaio, os quais continham tinturas de malva e calêndula em diferentes concentrações (25, 50, 75, 150, 250, 500, 750 e 1000 μg/ml), e substâncias controle (água salina e clorexidina 0,12%). O teste foi realizado em triplicata e os náuplios vivos foram contados após 24 h. A concentração letal média (CL50) foi obtida e submetida a análise Probit através do software StatPlus®. As curvas de sobrevivência e testes de LogRank foram realizados para as tinturas comparando com os controles, através do software GraphPad® Prism. A CL50 (μg/ml ± erro-padrão) para a malva foi de 276,08 ± 41,12, e para a calêndula 268,95 ± 44,09, sendo ambas as tinturas consideradas ativas. Verificou-se diferença estatística na curva de sobrevivência tanto para a malva quanto para a calêndula quando comparadas com solução salina (p<0,0001), indicando maior toxicidade das tinturas. Também houve diferença estatística quando as tinturas foram comparadas a clorexidina (p<0,0001), indicando maior toxicidade da clorexidina. Não houve diferença na taxa de sobrevivência dos náuplios, quando analisadas as tinturas de malva e calêndula (p = 0,8089). Pôde-se concluir que as tinturas de malva 10% e calêndula 10% apresentaram toxicidade moderada frente a Artemia salina.

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Anti-inflammatory and antiresorptive effects of Calendula officinalis on inflammatory bone loss in rats

Abstract: CLO can be a potential therapeutical adjuvant in the treatment of periodontitis.

Cited by 18 publications

References 35 publications

Protective effect of Platymiscium floribundum Vog. in tree extract on periodontitis inflammation in rats

Protective effect of Platymiscium floribundum Vog. in tree extract on periodontitis inflammation in rats

Novel natural product‐based oral topical rinses and toothpastes to prevent periodontal diseases

Avaliação da toxicidade de diferentes concentrações de tinturas de malva e calêndula através do bioensaio com Artemia salina

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