Anti-inflammatory and Antioxidant Effects of Captopril Compared to Methylprednisolone in l-Arginine-Induced Acute Pancreatitis

El-Ashmawy, Nahla E.; Khedr, Naglaa F.; El-Bahrawy, Hoda A.; Hamada, Omnia B.

doi:10.1007/s10620-018-5036-1

Cited by 30 publications

(22 citation statements)

References 37 publications

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“…Several studies demonstrated that ACE inhibitors prevent a wide variety of key events, among them anti‐inflammatory effects. In this context, the possible protective role of captopril as anti‐inflammatory and antioxidant in pancreatic inflammation was investigated, whose captopril showed a significant reduction in pancreatic TNF‐α concentration [28] . Besides, a captopril study investigates the ability to attenuate the cardiac inflammatory process associated with arterial hypertension, showing the inflammation process decrease in the left ventricle of hypertensive rats through an activation reduction of pro‐inflammatory factors [29]…”

Section: Resultsmentioning

confidence: 99%

“…In this context, the possible protective role of captopril as anti-inflammatory and antioxidant in pancreatic inflammation was investigated, whose captopril showed a significant reduction in pancreatic TNF-α concentration. [28] Besides, a captopril study investigates the ability to attenuate the cardiac inflammatory process associated with arterial hypertension, showing the inflammation process decrease in the left ventricle of hypertensive rats through an activation reduction of pro-inflammatory factors. [29] Finally, the Cuphea species are reported with antiinflammatory and antihypertensive potential and have a great diversity of flavonols derivatives as quercetin.…”

Section: Peak [A]mentioning

confidence: 99%

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Polyphenolic Composition and in Vitro Antihypertensive and Anti‐Inflammatory Effects of Cuphea lindmaniana and Cuphea urbaniana

Santos

Soares

Beltrame

et al. 2021

Chemistry & Biodiversity

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The present study investigates the chemical composition, anti-inflammatory, and antihypertensive activities, in vitro, from extracts of Cuphea lindmaniana and Cuphea urbaniana leaves. The extraction was performed ultrasound-assisted, and UHPLC/MS analysis was in positive mode ionization. The anti-inflammatory activity of the extracts and miquelianin were assayed at concentrations 0.001 -10 μg/mL by chemotaxis on rat polymorphonuclear neutrophils. The antihypertensive activity was performed by angiotensin-converting enzyme (ACE) inhibition. From the nineteen proposed compounds, six of them are described for the first time in this genus. The extracts displayed antichemotactic effect with a reduction of 100 % of the neutrophil migration, in vitro, in most concentrations. The ACE-inhibition presented results ranging from 19.58 to 22.82 %. In conclusion, C. lindmaniana and C. urbaniana extracts contain a rich diversity of flavonoids and display in vitro anti-inflammatory and antihypertensive potential. Thus, this study could serve as a scientific baseline for further investigation, on developmental novel products with therapeutic actions.

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Section: Resultsmentioning

confidence: 99%

Section: Peak [A]mentioning

confidence: 99%

Polyphenolic Composition and in Vitro Antihypertensive and Anti‐Inflammatory Effects of Cuphea lindmaniana and Cuphea urbaniana

Santos

Soares

Beltrame

et al. 2021

Chemistry & Biodiversity

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“…Captopril is an angiotensin-converting enzyme inhibitor (ACEI) that is widely used for hypertension management. Other potential effects of captopril have also been reported, including antioxidation, anti-inflammation, cardio-protection, and vasodilation [ 32 , 33 , 34 ]. In this study, captopril was used as a positive control agent.…”

Section: Introductionmentioning

confidence: 99%

Diosmetin Ameliorates Vascular Dysfunction and Remodeling by Modulation of Nrf2/HO-1 and p-JNK/p-NF-κB Expression in Hypertensive Rats

et al. 2021

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Diosmetin is a citrus flavonoid that has antioxidant and anti-inflammatory effects. This study examined the effect of diosmetin on blood pressure and vascular alterations and its underlying mechanisms in experimentally hypertensive rats. Male Sprague rats were administered Nω-nitro-L-arginine methyl ester L-NAME for five weeks and were given diosmetin at doses of 20 or 40 mg/kg or captopril (5 mg/kg) for two weeks. Diosmetin alleviated hypertension, improved endothelial dysfunction, and suppressed the overactivity of sympathetic nerve-mediated vasoconstriction in aorta and mesentery hypertensive rats (p < 0.05). Increases in plasma and aortic tissue malondialdehyde (MDA) and carotid superoxide generations and reductions of plasma superoxide dismutase, catalase, and nitric oxide in hypertensive rats were ameliorated by diosmetin (p < 0.05). Diosmetin increased the protein expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) in hypertensive rats. Furthermore, diosmetin mitigated hypertrophy and collagen accumulation of the aortic wall in L-NAME rats. It exhibited an anti-inflammatory effect by reducing interleukin-6 (IL-6) accumulation and by overexpressing the phospho-c-Jun N-terminal kinases (p-JNK) and the phospho-nuclear factor-kappaB (p-NF-κB) proteins in the aorta (p < 0.05). Captopril was a positive control substance and had similar effects to diosmetin. In summary, diosmetin reduced blood pressure and alleviated vascular abnormalities in L-NAME-treated rats. These effects might be related to antioxidant and anti-inflammatory effects as well as to the modulation of the expression of the Nrf2/HO1 and p-JNK/NF-κB proteins.

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“…Although AP may have different etiologies, the clinical presentation typically includes auto-degeneration of the tissue upon the activation of pancreatic enzymes and the consequent infl ammation caused by the release of such key pro-infl ammatory cytokines as interleukins (ILs) and tumor necrosis factor-alpha (TNF-α) (2). TNF-α promotes infl ammatory cells infi ltration including neutrophils and macrophages to accumulate in the pancreas, which results in exacerbating the local infl ammatory response in the pancreas and progressing into a systemic infl ammatory response (3).…”

Section: Introductionmentioning

confidence: 99%

The effects of a TNF-alpha inhibitor and HBO combination on the severity of pancreatitis and oxidative response in an experimental model of acute pancreatitis

Taşçı¹,

Şenocak²,

Lapsekili³

et al. 2019

BLL

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OBJECTIVES: We aimed to investigate the effects of infl iximab and HBO (hyperbaric oxygen) used alone or in combination on oxidative stress and the severity of pancreatitis in an experimental model of AP (acute pancreatitis). MATERIAL AND METHODS: A total of 60 rats were randomly divided into fi ve groups. Group 1 underwent laparotomy; Group 2 underwent experimental AP; Group 3 was given an infl iximab infusion and underwent AP; Group 4 was subjected to HBO therapy after AP; and Group 5 was given infl iximab infusion before AP and subjected to HBO therapy. Serum amylase, superoxide dismutase (SOD), malondialdehyde (MDA), and glutathione peroxidase (GPX) levels in the pancreas tissues were measured. The pancreatic tissue samples were scored. RESULTS: There were statistically signifi cant differences in the histopathological scores and amylase levels between non-treated AP and all the three treatment groups. Group 5 had the closest histopathological scores to the sham group. MDA levels were signifi cantly different between non-treated AP and all the three treatment groups, but the SOD levels and GPX values were not. CONCLUSIONS: Combination of HBO therapy and Infl iximab showed a synergistic effect on the reduction of histopathological severity and mortality in acute pancreatitis. All treatment modalities reduced the pathological fi ndings by decreasing lipid peroxidation and partly increasing the antioxidant capacity in early period (Tab.

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Anti-inflammatory and Antioxidant Effects of Captopril Compared to Methylprednisolone in l-Arginine-Induced Acute Pancreatitis

Abstract: Captopril treatment showed a protective and comparable effect with MP treatment in AP rat model.

Cited by 30 publications

References 37 publications

Polyphenolic Composition and in Vitro Antihypertensive and Anti‐Inflammatory Effects of Cuphea lindmaniana and Cuphea urbaniana

Polyphenolic Composition and in Vitro Antihypertensive and Anti‐Inflammatory Effects of Cuphea lindmaniana and Cuphea urbaniana

Diosmetin Ameliorates Vascular Dysfunction and Remodeling by Modulation of Nrf2/HO-1 and p-JNK/p-NF-κB Expression in Hypertensive Rats

The effects of a TNF-alpha inhibitor and HBO combination on the severity of pancreatitis and oxidative response in an experimental model of acute pancreatitis

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