Anti-inflammatory and anti-nociceptive activities of the stem bark extracts from Allanblackia monticola STANER L.C. (Guttiferae)

Nguemfo, Edwige Laure; Dimo, Théophile; Azebaze, Anatole Guy Blaise; Asongalem, Emmanuel Acha; Alaoui, Katim; Dongmo, Alain Bertrand; Cherrah, Yahia; Kamtchouing, Pièrre

doi:10.1016/j.jep.2007.08.022

Cited by 39 publications

(24 citation statements)

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“…Esto indicaría que componentes de P. alliacea pueden estar involucrados en inhibición de la liberación de agentes pro-inflamatorios, responsables de la formación del exudado (Nguemfo et al 2007). …”

Section: Controlunclassified

Efecto antiinflamatorio y antioxidante del extracto hidroalcohólico de Petiveria alliacea

2013

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ResumenLos radicales libres y el daño oxidativo están relacionados con la muerte celular, siendo la peroxidación lipídica un mecanismo que lleva a la destrucción oxidativa de la membrana celular. Además, en procesos inflamatorios, uno de los primeros estadios es la permeabilidad vascular incrementada (formación del edema) seguido de la extravasación de los fluídos, migración de leucocitos al sitio dañado y liberación de proteínas pro-inflamatorias. Evaluamos el efecto antioxidante y antiinflamatorio para Petiveria alliacea "mucura". Para el efecto antioxidante, se evaluó la formación de especies reactivas al ácido tiobarbitúrico como indicador de la peroxidación lipídica. Dosis 200mg/mL de Petiveria alliacea disminuyó significativamente en un 42% los niveles de MDA comparado con el agua (control negativo). En la evaluación antiinflamatoria, se indujo la inflamación por inyección de carragenina (solución al 1%), en la parte subplantar de ratones y en la "bolsa de aire subcutánea" de ratas para la inflamación aguda y crónica respectivamente. En la evaluación antiinflamatoria hay una máxima reducción del edema en un 23,26% a las 4 horas del tratamiento. Para la inflamación crónica hay una reducción del 25,9% y 29,5% del peso y volumen del exudado extraído, respectivamente, así como una reducción del 24% de peso de tejido fibroso. Estos resultados evidencian efecto antioxidante y antiinflamatorio de Petiveria alliacea.Palabras clave: Petiveria alliacea; antioxidante; antiinflamatorio; peroxidación; radical libre. AbstractThe free radicals and the oxidative damage are related with cellular death, with the lipid peroxidation being a mechanism that leads to oxidative destruction of the cellular membrane. Furthermore, in inflammatory process, one of the first stages is the incremented vascular permeability (formation of the oedema) followed with the extravasation of the fluids, migration of the leucocytes to the damaged site and release of pro-inflammatory proteins. Was evaluated antioxidants and anti-inflammatory of Petiveria alliacea "mucura". For antioxidants effect, was evaluated formation of thiobarituric acid reactive substances as indicator of lipid peroxidation. Doses 200 mg/mL of Petiveria alliacea decrease significatly in 42% levels of MDA compared to water (negative control). In the antiinflammatory evaluation, inflammation was analyzed in the carrageenan-induced paw oedema test in mice (solution to 1 %) and in the "carrageenan-induced air-pouch formation" of rates for acute and chronic inflammation respectively. In anti-inflammatory evaluation there is a significant reduction of the edema in 23.26% at 4hrs at the treatment. For chronic inflammation there is a reduction of 25.9% and 29.5% of the weight and volume of exuded extract respectively, as well as a reduction of 24% of weight of fibrous tissue. These results demonstrate antioxidant and anti-inflammatory effects of Petiveria alliacea.Keywords: Petiveria alliacea; antioxidant; anti-inflamatory; peroxidation; free radical. IntroducciónUn antioxidante se ...

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Section: Controlunclassified

Efecto antiinflamatorio y antioxidante del extracto hidroalcohólico de Petiveria alliacea

2013

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“…Inflammation is usually associated with pain as a secondary process resulting from the release of analgesic mediators 6 . Non-steroidal anti-inflammatory agents -NSAIDS have been prepared and marketed 6 , however, these drugs are known to provoke gastrointestinal irritation 7 . Thus, recognition of inflammatory processes incidence caused by cancer robustly correlates with an increasing attention on safety and effectiveness of novel pharmaceuticals.…”

Section: Introductionmentioning

confidence: 99%

Lectin from Crataeva tapia bark exerts antitumor, anti-inflammtory and analgesic activities

Araújo

Vaz

Aguiar

et al. 2011

Nat. Prod. Bioprospect.

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Abstract:Crataeva tapia bark lectin was evaluated for its antitumor activity against sarcoma 180 in Swiss albino mice. The antiinflammatory and analgesic properties were investigated in models of inflammation and nociception. The anti-inflammatory assay was induced by carrageenan induced peritonitis and the analgesic activity was induced by acetic acid-induced writhing response. The lectin presents low toxicity with a LD 50 of 2,500 mg/kg body weight and significant antitumor activity causing inhibition of tumor growth. The lectin also promoted significant reduction (35.4%) in the number of neutrophil migration induced by carrageenan. Concerning its analgesic property, the lectin inhibits abdominal contractions induced by acetic acid. The current results revealed a lectin with significant antitumoral, anti-inflammatory and antinociceptive activities. Further investigations to unveil the exact mechanisms are needed.

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“…Edema thickness was measured using digital caliper at 0, 15, 30, 45, 60, 90, 120, 150, 180, 210, 240, 270, 300, 330, and 360 min after carrageenan injection [12,13]. The calculation of the edema volume was conducted using formula area under curve (AUC) and percentage of inhibition of inflammation [13][14][15].…”

Section: Anti-inflammatory Studymentioning

confidence: 99%

“…The analgesic activity of EL was tested using acetic acid-induced writhing method [11,14,15,17]. Female mice Swiss were divided randomly into five groups (n=5).…”

Section: Analgesic Studymentioning

confidence: 99%

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Evaluation of Antihyperlipidemic, Anti-Inflammatory, and Analgesic Activities of Eurycoma Longifolia in Animal Models

Hendra

Fenty

Andreani

et al. 2017

Int J Pharm Pharm Sci

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Objective: To investigate the anti-hyperlipidemic, anti-inflammatory and analgesic properties of of E. longifolia root extract in animal models. Methods:In this study, glucose-fructose enriched diet-induced hyperlipidemia, carrageenan-induced paw edema and acetic acid-induced writhing were used to evaluate the anti-hypertriglyceridemia, anti-inflammatory and analgesic activities, respectively. At the end of the experiment of glucose-fructose enriched diet-induced hyperlipidemia, blood samples were collected and estimation of blood lipids were carried out. Edema thickness was measured using digital caliper at 0, 15, 30, 45, 60, 90, 120, 150, 180, 210, 240, 270, 300, 330, and 360 min after carrageenan injection. The number of abdominal writhing for each mouse was observed and counted during a period of 1 h post injection of acetic acid.Results: E. longifolia root extract demonstrated a significant reduction of triglyceride levels (p<0.05) compared with the control group in glucosefructose enrich diet in rats. In anti-inflammatory test, the extract significantly inhibited the carrageenan induced paw edema formation (p<0.05). The extract also significantly decreased the number of writhing in acetic acid-induced mice (p<0.05).Conclusion: E. longifolia root extract shown a significant anti-hypertriglyceridemia, anti-inflammatory and analgesic activities. Further studies are needed to determine mechanisms for its acitivities of E. longifolia root extract.

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Anti-inflammatory and anti-nociceptive activities of the stem bark extracts from Allanblackia monticola STANER L.C. (Guttiferae)

Cited by 39 publications

References 30 publications

Efecto antiinflamatorio y antioxidante del extracto hidroalcohólico de Petiveria alliacea

Efecto antiinflamatorio y antioxidante del extracto hidroalcohólico de Petiveria alliacea

Lectin from Crataeva tapia bark exerts antitumor, anti-inflammtory and analgesic activities

Evaluation of Antihyperlipidemic, Anti-Inflammatory, and Analgesic Activities of Eurycoma Longifolia in Animal Models

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