Anti-inflammatory adrenal steroids that neither inhibit skin collagen synthesis nor cause dermal atrophy

DiPetrillo, T.

doi:10.1001/archderm.120.7.878

Cited by 7 publications

(1 citation statement)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, all are associated with potential and distinct side-effects, which include but are not limited to skin atrophy and local infections (steroids) [5,9,38], hypersensitivity skin reactions or systemic contact allergies (antifungals, antibiotics) [3,10,23], pruritus, skin burning, erythema, and hyperesthesia (all with tacrolimus) [29]. For this reason, some physicians prefer herbal medicines like hamamelis, which are less likely to produce severe sideeffects than other treatment options and provide similar efficacy.…”

Section: Introductionmentioning

confidence: 99%

Hamamelis in children with skin disorders and skin injuries: results of an observational study

Wolff

Kieser

2006

Eur J Pediatr

View full text Add to dashboard Cite

Published clinical experience with hamamelis ointment in children is limited. This observational study included children (age 27 days to 11 years) with minor skin injuries, diaper dermatitis, or localized inflammation of skin. The children received either hamamelis ointment or dexpanthenol ointment in groups at a 3-to-1 ratio. Baseline and post-treatment assessments compared the total scores of predefined signs and symptoms for each condition. Physicians and parents were asked for a global assessment of efficacy and tolerability of the respective treatments at the end of therapy. A total of 309 children were treated (hamamelis n = 231; dexpanthenol n = 78). The treatment groups were comparable regarding demographic data and baseline total scores of signs and symptoms. In all three diagnosis groups, the efficacy of hamamelis and dexpanthenol was shown by a statistically significant and clinically relevant decrease of total scores from baseline to endpoint (p < 0.0001 for each group, Wilcoxon signed-rank test). Overall, the results for the hamamelis and the dexpanthenol groups were similar. Descriptive advantages for the hamamelis group were observed for a number of parameters and diagnosis groups. Both treatments were well tolerated. Ratings of the tolerability of hamamelis were "excellent" or "good" in 99.1% (physicians) and 98.2% (parents) of cases, respectively. The corresponding ratings for dexpanthenol were 97.4 and 92.3%. In conclusion, hamamelis ointment is an effective and safe treatment for certain skin disorders in children up to the age of 11 years. The observed effects are similar to dexpanthenol.

show abstract

Section: Introductionmentioning

confidence: 99%