Anti-inflammatory activity of tea (Camellia sinensis) root extract

Chattopadhyay, Partha; Besra, Shila Elizabeth; Gomes, Antony; Das, Mitali; Sur, Pratima; Mitra, Subrata; Vedasiromoni, J. R.

doi:10.1016/j.lfs.2003.07.053

Cited by 45 publications

(34 citation statements)

References 31 publications

(32 reference statements)

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“…The inhibitory effect of high dose of GTE in the second phase also suggests a peripherally action of GTE. Chattopadhyay et al (2004) reported anti-inflammatory effect of tea root extract on arachidonic acid-induced paw oedema in rats (21). Naloxone, a nonselective opioid antagonist significantly reversed the antinociceptive effect of GTE in the second phase suggesting a possible opioidergic involvement in the actions of GTE.…”

Section: Discussionmentioning

confidence: 99%

Antinociceptive Effect of Hydroalcoholic Extract of Iranian Green tea in the Formalin Test in Rats

Arzi

Ghorbanzadeh²,

Khorasgani³

2013

Jundishapur J Nat Pharm Prod

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Background: Tea (Camellia sinensis) has been utilised, since time immemorial, as a beverage possessing encouraging health benefits. Little scientific evidence exists in literature on the effect of this plant on pain. Objectives: To investigate the antinociceptive activity of Iranian green tea extract. Materials and Methods:The hydroalcoholic extract was administered to male Wistar rats. Formalin paw test was used to evaluate the antinociceptive activity. Plant extract (25, 50, 100 and 200 mg/kg, i.p.) (n = 6 for each group) or vehicle (n = 6) was administered 30 min before the subplantar formalin injection. Results: The extract caused a significant dose-related (50, 100, 200 mg /kg, i.p.) inhibition of the first phase and onset of chronic phase (200 mg /kg, i.p.) of formalin induced nociception. The results showed that the pre-treatment of rats with naloxone (1 mg/kg, i.p.) significantly (P < 0.001) reversed antinociception by Green tea extract (GTE) (200 mg/kg, i.p.) in the inflammatory phase and had no effect on phase 1. Conclusions: These results indicate that GTE produces dose-related antinociception in chemical pain model and one of its possible mechanisms involves opioid pathways.

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Section: Discussionmentioning

confidence: 99%

Antinociceptive Effect of Hydroalcoholic Extract of Iranian Green tea in the Formalin Test in Rats

Arzi

Ghorbanzadeh²,

Khorasgani³

2013

Jundishapur J Nat Pharm Prod

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“…Pharmacological studies of camomile tea (Camellia sinensis) root extract have shown it to possess antiinflammatory activity at 1/10 th of its median lethal dose in rodents. Camomile tea root extract inhibited arachidonic acid-induced paw edema in rats by inhibiting both the cyclo-oxygenase and lipo-oxygenase pathways of arachidonic acid metabolism 5 . Ductal constriction associated with consumption of camomile tea is likely to be produced by a similar pharmacological mechanism to that observed with NSAIDs.…”

Section: E T T E R S T O T H E E D I T O Rmentioning

confidence: 95%

Premature constriction of the fetal ductus arteriosus following the maternal consumption of camomile herbal tea

Sridharan

Archer

Manning

2009

Ultrasound in Obstet & Gyne

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“…volume of the injected paws was measured using a plethysmograph (Ugo Basile 7140, Italy) before and every three days after the induction of arthritis till day 21. On day 21 st , at the end of the experimental period, the animals were sacrificed by cervical decapitation and blood was collected and separated plasma for assaying the hematological and biochemical parameters (Gokhale et al, 2002;Chattopadhyay et al, 2004). Arthritis was also assessed by body and spleen weight of rats.…”

Section: Anti Arthritic Activitymentioning

confidence: 99%

Further studies on membrane stabilizing, anti-inflammatory and FCA induced arthritic activity of various fractions of bark of Machilus macrantha in rats

Tatiya¹,

Saluja²

2011

Rev. bras. farmacogn.

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Machilus macrantha Nees, Lauraceae, bark is traditionally used in the treatment of asthma, tuberculosis and rheumatoid arthritis. In order to validate, mechanism based anti-inflammatory activity of fractions M. macrantha bark are investigated for first time. Test materials viz. petroleum ether (PE), alkaloidal fraction (CH), acetone extracts (TAN) and mucilage (MM) (250 and 500 mg/kg, p.o.) obtained from M. macrantha bark were tested for membrane stabilizing, antinociceptive; anti inflammatory and Freund's complete adjuvant (FCA) induced arthritis activity. Diclofenac sodium and morphine were used as the reference standards in pharmacological assay. Test materials have significantly (p<0.01) inhibited paw edema after Carrageenan and histamine induction at higher doses. Administration of test materials of M. macrantha (250 and 500 mg/kg b.w.) significantly reduced abdominal writhing, formalin nociception, cotton pellet granuloma and vascular permeability in experimental animal. In addition to this, bark of M. macrantha showed chronic anti-rheumatic effect by suppressing the swelling volume, arthritis index, hematological and biochemical parameters (ESR, RA factor, CRP, liver transferase enzyme) in FCA-induced arthritis. It also significantly inhibited protein denaturation, heat-induced haemolysis of RBC and reduction in total leukocyte migration. Bioassay guided fractionation of the pet. ether extract of bark of M. macrantha led to isolation and characterization of β-sitosterol and stigma sterol confirmed by its HPLC, NMR and GC-MS study. In conclusion, extracts of M. macrantha bark can be explored as a therapeutic agent for the treatment of acute and chronic arthritis.

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Anti-inflammatory activity of tea (Camellia sinensis) root extract

Cited by 45 publications

References 31 publications

Antinociceptive Effect of Hydroalcoholic Extract of Iranian Green tea in the Formalin Test in Rats

Antinociceptive Effect of Hydroalcoholic Extract of Iranian Green tea in the Formalin Test in Rats

Premature constriction of the fetal ductus arteriosus following the maternal consumption of camomile herbal tea

Further studies on membrane stabilizing, anti-inflammatory and FCA induced arthritic activity of various fractions of bark of Machilus macrantha in rats

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