Anti-inflammatory activities of several diterpenoids isolated from Hemionitis albofusca

Pei, Xiaoxiao; Lou, Yuxia; Ren, Qianqian; Liu, Na; Dai, Xiling; Ye, Mingfu; Huang, Guozheng; Cao, Ji

doi:10.1007/s00210-023-02626-y

Cited by 3 publications

(2 citation statements)

References 35 publications

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“…We previously found that JXE‐23 , together with other diterpenes from A. albofusca , drastically reduced the quantity of cellular NO generation by blocking the expression and transcription of the iNOS protein and the inflammatory mediators TNF‐ α and IL‐6 [23] . Further study of this compound revealed that it also inhibited the proliferation of cancer cells.…”

Section: Introductionmentioning

confidence: 96%

“…We previously found that JXE-23, together with other diterpenes from A. albofusca, drastically reduced the quantity of cellular NO generation by blocking the expression and transcription of the iNOS protein and the inflammatory mediators TNF-α and IL-6. [23] Further study of this compound revealed that it also inhibited the proliferation of cancer cells. Herein, we would like to report its potency in diminishing the viability of MDA-MB-468 EGFR-overexpressing TNBC cells and investigate the possible underlying mechanism.…”

Section: Introductionmentioning

confidence: 99%

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Discovery of a Pimaradiene that Decreases Viability of MDA‐MB‐468 Cells Through Inhibition of EGFR Signaling Pathway

Wang,

Qin,

Liu

et al. 2024

Chemistry & Biodiversity

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Triple‐negative breast cancer (TNBC) is characterized by strong invasiveness, high relapse rates and poor overall survival and occurs in approximately 15‐20% of all breast cancer cases. Natural compounds are a promising option for managing breast cancer. ent‐8(14),15‐Pimaradiene‐2β,19‐diol (JXE‐23), is a pimaradiene isolated from the fern Aleuritopteris albofusca. However, the effects and molecular mechanisms of JXE‐23 on cancer cells are still unknown. Thus, this study was designed to determine the potential of JXE‐23 for its anticancer properties in TNBC cells. JXE‐23 was evaluated for their antiproliferative activity in vitro against human breast cancer cell lines, and showed selectively cytotoxic activity against MDA‐MB‐468 EGFR‐overexpressing TNBC cancer cell lines, with an IC50 value at 1.17±0.04 μM. Moreover, mechanistic investigations indicated that JXE‐23 was significantly capable of inhibiting cell proliferation and viability of MDA‐MB‐468 cells. In addition, JXE‐23 exerted an anticancer effect against MDA‐MB‐468 cells via restraining cell migration in a dose‐dependent mode. Moreover, after treatment with JXE‐23, the protein expressions of pEGFR, pERK, pAKT and p70S6K were significantly reduced in MDA‐MB‐468 cells. The results underscored that JXE‐23 could be a potential lead compound for the treatment of EGFR‐overexpressing TNBC cells.

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Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Discovery of a Pimaradiene that Decreases Viability of MDA‐MB‐468 Cells Through Inhibition of EGFR Signaling Pathway

Wang,

Qin,

Liu

et al. 2024

Chemistry & Biodiversity

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Diterpenoids from the Resin of Liquidambar formosana Hance and Their Anti‐inflammatory Activities

Babu Sura,

Liu,

Cheng

2024

ChemistrySelect

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Liquidambarine D (1), a new labdane‐type diterpenoid, and nineteen known compounds including five labdanes (2–6), eight abietanes (7–14), four pimaranes (16–19), and two nor‐diterpenoids (15, 20) were isolated from the resin of Liquidambar formosana Hance. The new compound was characterized by the combination of spectroscopic and computational methods. With the exception of 15‐hydroxydehydroabietic acid (13), all the known compounds were reported for the first time from the resins of Liquidambar species. All these isolates were evaluated for their inhibitory effects in RAW264.7 macrophage cells, revealing that compounds, acetylisocupressic acid (3), (13S)‐15‐acetoxylabd‐8(17)‐en‐19‐oic acid (6), abietic acid (7), dehydroabietic acid (11), abieta‐8,11,13,15‐tetraen‐18‐oic acid (12), and 4‐epi‐isopimaric acid (16) could suppress lipopolysaccharide‐induced iNOS expression in RAW 264.7 cells and disclosing their structure activity relationships.

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ent-8(14),15-Pimaradiene-2β,19-diol, a diterpene from Aleuritopteris albofusca, inhibits growth and induces protective autophagy in hepatocellular carcinoma cells

Zhang,

Liu,

Wang

et al. 2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Anti-inflammatory activities of several diterpenoids isolated from Hemionitis albofusca

Cited by 3 publications

References 35 publications

Discovery of a Pimaradiene that Decreases Viability of MDA‐MB‐468 Cells Through Inhibition of EGFR Signaling Pathway

Discovery of a Pimaradiene that Decreases Viability of MDA‐MB‐468 Cells Through Inhibition of EGFR Signaling Pathway

Diterpenoids from the Resin of Liquidambar formosana Hance and Their Anti‐inflammatory Activities

ent-8(14),15-Pimaradiene-2β,19-diol, a diterpene from Aleuritopteris albofusca, inhibits growth and induces protective autophagy in hepatocellular carcinoma cells

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