Anti-IgG activity on peripheral blood lymphocytes in psoriasis

Rimbaud, P.

doi:10.1001/archderm.108.3.371

Cited by 8 publications

(6 citation statements)

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“…Such an activity was not found in psoriatic arthropathy by Tapanes, Rawson & Hallander (1972), but has been recently described by Howell et al (1972). Krogh & Tonder (1972) have found anti-IgG factors in psoriatic lesions and Rimbaud et al (1973) have reported a similar anti-IgG activity on peripheral blood lymphocytes. The classical serological reactions for rheumatoid factor detect mainly agglutinating antibodies and are always negative in psoriatic arthropathy.…”

Section: This Work Emphasizes Some Disturbances Ofthe Immunoglobulinsmentioning

confidence: 68%

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Immunological aspects of psoriasis.

et al. 1976

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Sixty patients with psoriasis have been studied for quantitative estimation of serum immunoglobulin A, G and M (60 cases), immunoglobulin E (43 cases), salivary immunoglobulin A (28 cases) and anti-IgG factors in the serum (40 cases). All the data have been statistically compared to a large control group (300 subjects). The results show an increase of the serum IgG and IgA means, an increase of salivary IgA which is correlated with the serum IgA, an increase of IgE levels in some patients and the presence of anti-IgG activity in the serum of 45% of patients with psoriasis. All these findings are statistically significant when compared to controls. These data could be in favour of auto-immune processes in psoriasis.

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Section: This Work Emphasizes Some Disturbances Ofthe Immunoglobulinsmentioning

confidence: 68%

“…Serum immunoglobulin disturbances have already been described by many authors (Fraser, Dick & Grichton, 1969;Marghescu & Braun-Falco, 1970;Varelzidis & Theodoris, 1971;Schneider & Gurenci, 1972;Lai a Fat & Van Furth, 1974). Our group has previously published data concerning anti-IgG activity on blood lymphocytes of psoriatic patients (Rimbaud et al, 1973).…”

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confidence: 99%

Immunological aspects of psoriasis.

et al. 1976

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“…The report of an anti-IgG activity on some psoriatic peripheral blood lymphocytes (Rimbaud et al, 1973) can be thus considered to be due to the presence of Fc-y-receptor cells with a high avidity for IgG and not to the presence of rheumatoid factor on lymphocytes. Some psoriatic patients (about 40%) have higher percentages of such cells than normal human donors.…”

Section: Discussionmentioning

confidence: 97%

“…Three techniques using erythrocyte (E)-antibody (A) complexes were usued. The so-called 'rheumatoid' rosette test (R-RFC), according to a method previously reported (Rimbaud et al, 1973) with fresh, human group O, rhesus D negative erythrocytes coated with small amounts (i 14000) of inactivated rabbit anti-human erythrocyte IgG (Pr. A. Eyquem, Institut Pasteur, Paris).…”

Section: Ea-rosette Forming Mononuclear Cells (Ea-rec)mentioning

confidence: 99%

Immunological aspects of psoriasis.

Clot

Meynadier

et al. 1978

Br J Dermatol

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An anti-IgG activity has previously been reported at the cellular level in patients with psoriasis. This activity was demonstrated by the so-called 'rheumatoid' rosette test. In the present work the nature of 'rheumatoid' rosette-forming cells was studied in comparison with other EA rosette techniques. The use of purified cell populations showed that the lymphocytes participating in the 'rheumatoid' rosette phenomenon were lacking conventional T and B cell membrane markers, and were thus referred to as null cells. Such mononuclear cells bearing a receptor for the Fc part of IgG were able to act as killer cells to IgG-coated target cells. The cytotoxic activity was mainly restricted to a small proportion of lymphocytes forming 'rheumatoid' rosettes which had a high avidity for EA complexes. Such cytotoxicity could contribute to the aetiology of lesions in psoriasis.

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“…We have also demonstrated the presence of an anti-IgG activity in the serum (45% ofthe patients), confirming the data from Howell et al (1972) and Florin-Christensen et al (1974). Such anti-IgG factors have been described in psoriatic skin (Krogh & Tonder, 1972) and on peripheral blood lymphocytes by ourselves (Rimbaud et al, 1973). Cormane, Hunyadi & Hamerlinck (1976) have demonstrated andnuclear antibodies bound to the membranes of circulating lymphocytes.…”

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confidence: 84%

Immunological aspects of psoriasis.

Meynadier

Clot

et al. 1976

Br J Dermatol

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SUMMARY We have investigated lymphocyte subpopulations (six different markers) and T cell functions (mitogen responses and serum thymic factor determination) in twenty patients with psoriasis compared with thirty‐five healthy subjects. Normal results were found for B cell markers, but significantly lower numbers of T cells were assessed by E‐rosettes and anti HTLA serum. Mitogen responses were normal for PHA but depressed after Con A and PWM stimulation. Lastly, thymic factor levels were significantly higher in psoriasis than in normal subjects of the same age. These findings could be in favour of a T cell subpopulation defect involved in an auto‐immune pathogenesis of psoriasis.

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Anti-IgG activity on peripheral blood lymphocytes in psoriasis

Cited by 8 publications

References 0 publications

Immunological aspects of psoriasis.

Immunological aspects of psoriasis.

Immunological aspects of psoriasis.

Immunological aspects of psoriasis.

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