Anti-IgG activity on peripheral blood lymphocytes in psoriasis

Immunological aspects of psoriasis.

“…Such an activity was not found in psoriatic arthropathy by Tapanes, Rawson & Hallander (1972), but has been recently described by Howell et al (1972). Krogh & Tonder (1972) have found anti-IgG factors in psoriatic lesions and Rimbaud et al (1973) have reported a similar anti-IgG activity on peripheral blood lymphocytes. The classical serological reactions for rheumatoid factor detect mainly agglutinating antibodies and are always negative in psoriatic arthropathy.…”

“…The presence of such IgG antibodies has been reported in many other diseases including those due to auto-immune mechanisms. This finding, the anti-IgG activity bound to blood lymphocytes (Rimbaud et al, 1973), the close correlation between psoriasis and HL-A antigens (Rimbaud et al, 1974) and the increase of serum and salivary IgA could be in favour of auto-immune processes in psoriasis.…”

Immunological aspects of psoriasis.

“…We have also demonstrated the presence of an anti-IgG activity in the serum (45% ofthe patients), confirming the data from Howell et al (1972) and Florin-Christensen et al (1974). Such anti-IgG factors have been described in psoriatic skin (Krogh & Tonder, 1972) and on peripheral blood lymphocytes by ourselves (Rimbaud et al, 1973). Cormane, Hunyadi & Hamerlinck (1976) have demonstrated andnuclear antibodies bound to the membranes of circulating lymphocytes.…”

Immunological aspects of psoriasis.

“…The report of an anti-IgG activity on some psoriatic peripheral blood lymphocytes (Rimbaud et al, 1973) can be thus considered to be due to the presence of Fc-y-receptor cells with a high avidity for IgG and not to the presence of rheumatoid factor on lymphocytes. Some psoriatic patients (about 40%) have higher percentages of such cells than normal human donors.…”

“…Three techniques using erythrocyte (E)-antibody (A) complexes were usued. The so-called 'rheumatoid' rosette test (R-RFC), according to a method previously reported (Rimbaud et al, 1973) with fresh, human group O, rhesus D negative erythrocytes coated with small amounts (i 14000) of inactivated rabbit anti-human erythrocyte IgG (Pr. A. Eyquem, Institut Pasteur, Paris).…”