2017
DOI: 10.1007/s10616-016-0061-4
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Abstract: Hyperuricemia is recognized as an important risk factor for gout. High dietary intake of purine-rich foods such as meats and sea foods increases uric acid (UA) levels in the blood. Taxifolin present in Siberian larch and strawberries has been reported to possess health promoting activities including anti-oxidant effect. In this study, we examined anti-hyperuricemic effect of taxifolin in both cultured hepatocytes and hyperuricemic model mice. In cultured AML12 hepatocytes, taxifolin significantly suppressed UA… Show more

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Cited by 18 publications
(15 citation statements)
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“…Thus, we have contrived an assay system for UA production in vitro employing cultured AML12 hepatocytes and a hyperuricemic animal model in vivo induced by administration of purine bodies to ICR mice [ 6 ]. Employing these in vitro and in vivo systems, we have found that some food components such as quercetin [ 6 ] and taxifolin [ 7 ] inhibit UA production in the hepatocytes and successively confirmed that these polyphenols are capable of suppressing the purine bodies-induced hyperuricemia [ 6 , 7 ] like allopurinol, a widely prescribed anti-hyperuricemic medicine, employed as a positive control agent in these studies. Since rodents including the mouse and rat have uricase which degrade uric acid to allantoin (humans lose uricase function), potassium oxonate (PO), a selectively competitive uricase inhibitor, is adopted to block the effect of hepatic uricase and to produce hyperuricemia in rodents [ 8 ].…”
Section: Introductionmentioning
confidence: 72%
“…Thus, we have contrived an assay system for UA production in vitro employing cultured AML12 hepatocytes and a hyperuricemic animal model in vivo induced by administration of purine bodies to ICR mice [ 6 ]. Employing these in vitro and in vivo systems, we have found that some food components such as quercetin [ 6 ] and taxifolin [ 7 ] inhibit UA production in the hepatocytes and successively confirmed that these polyphenols are capable of suppressing the purine bodies-induced hyperuricemia [ 6 , 7 ] like allopurinol, a widely prescribed anti-hyperuricemic medicine, employed as a positive control agent in these studies. Since rodents including the mouse and rat have uricase which degrade uric acid to allantoin (humans lose uricase function), potassium oxonate (PO), a selectively competitive uricase inhibitor, is adopted to block the effect of hepatic uricase and to produce hyperuricemia in rodents [ 8 ].…”
Section: Introductionmentioning
confidence: 72%
“…Isorhamnetin administration to hyperuricemic model mice Anti-hyperuricemic effect in the model mice was estimated as described previously (Adachi et al 2017b). Briefly, after acclimatization to the environment for 1 week, the mice were divided into five groups with similar body weight: normal group (n = 8), hyperuricemic model group (n = 12), allopurinol group (n = 8), low-dose of isorhamnetin group (n = 8) and high-dose of isorhamnetin group (n = 8).…”
Section: Animalsmentioning
confidence: 99%
“…The plasma was stored at -80°C until analyzed. The excised liver was washed with saline, cut into three pieces, frozen in liquid nitrogen, and stored at -80°C until analyzed (Adachi et al 2017b).…”
Section: Animalsmentioning
confidence: 99%
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“…Adachi et al reported in vivo study of taxifolin(125) for inhibitory activity against liver XO in liver (Fig. 22) 202.…”
mentioning
confidence: 99%