Anti-hypertensive medicinal plants and their mode of action

Rawat, Pooja; Singh, Pawan; Kumar, Vipin

doi:10.1016/j.hermed.2016.06.001

Cited by 31 publications

(12 citation statements)

References 110 publications

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“…[2] Therefore, complementary medicines for the treatment of hypertension are increasing popularity among the patients. [3,4] Recently, developing new strategies including use of nutritional and bioactive compounds with antihypertensive medications is of high attention. [5,6] Momordica charantia L (MC) is a member of the Cucurbitaceae family.…”

Section: Introductionmentioning

confidence: 99%

Effects of Momordica charantia L on blood pressure: a systematic review and meta- analysis of randomized clinical trials

Jandari

Ghavami

Ziaei

et al. 2020

International Journal of Food Properties

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Several reports have indicated a positive effect of Momordica charantia (MC) on blood pressure (BP); nevertheless, these findings have been controversial. Therefore, a systematic review and meta-analysis of randomized controlled trials (RCTs) were aimed to investigate the effects of MC supplementation on BP. PubMed, Scopus, ISI Web of Science, and Cochrane library databases were searched (up to June 2020) to identify RCTs investigating the effects of Momordica charantia supplementation on systolic blood pressure (SBP) and diastolic blood pressure (DBP). Weighted mean differences (WMD) were pooled using a random-effects model. Publication bias was assessed by Egger's and Begg's test and heterogeneity was evaluated using Q tests and the I 2 statistic. Eventually, only five articles (six treatment arms) 305 participants (154 as intervention group/151 as control), which reported data of interest entered for data analysis. The meta-analysis showed a non-significant reduction in SBP (WMD: −2.28 mmHg; 95% CI: −6.62, 2.05, P = .302), with significant heterogeneity between selected studies (I 2 = 77.3%) and (WMD: −0.8 mmHg, 95% CI: −2.65 to 1.04, P = .394) with significant between-study heterogeneity (I 2 = 38.1%). When studies were categorized based on participants' mean age and duration of intervention, SBP and DBP had a large non-significant decrease in subjects with equivalent and less than 50 years' subset and short duration (≤8 weeks'). Consumption of MC preparations was not associated with a significant reduction in either SBP or DBP. However, we found a significant hypotensive effect of MC in younger adults and in short-term interventions. Future adequately powered clinical trials, with larger sample size, which consider proper standardization of MC preparations and exclusively include hypertensive patients, are needed to investigate the clinical potential of MC on blood pressure control among these patients.

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Section: Introductionmentioning

confidence: 99%

Effects of Momordica charantia L on blood pressure: a systematic review and meta- analysis of randomized clinical trials

Jandari

Ghavami

Ziaei

et al. 2020

International Journal of Food Properties

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“…12 Numerous factors contribute to the pathophysiology of HTN, including increases in the renin-angiotensin-aldosterone system (RAAS), stimulation of the sympathetic nervous system (SNS), vasopressin (VP), disturbed G protein-coupled receptor signaling, inflammation, different T-cell roles, and the diversity of vasoactive peptides secreted by other endothelial cells and smooth muscle cells. 13 Increased arterial reactivity because of dysregulation in pro-oxidant enzymes and endothelial nitric oxide synthase (eNOS), increased basal and activated calcium levels via calcium channels, and cooccurrence of vascular smooth muscle cell (VSMC) hyperplasia and hypertrophy can cause enhanced vasoconstriction. 14 Augmented vascular stiffness is conducive to HTN, and its problems, such as atherosclerosis, indicating that therapy must be focused on vascular stiffness instead of only the modulation of peripheral vascular resistance.…”

Section: Pathophysiology Of Hypertensionmentioning

confidence: 99%

Medicinal Plants in the Treatment of Hypertension: A Review

et al. 2020

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Traditional medicine is a comprehensive term for ancient, culture-bound health care practices that existed before the use of science in health matters and has been used for centuries. Medicinal plants are used to treat patients with cardiovascular diseases, which may occur due to ailments of the heart and blood vessels and comprise heart attacks, cerebrovascular diseases, hypertension, and heart failure. Hypertension causes difficulty in the functioning of the heart and is involved in atherosclerosis, raising the risk of heart attack and stroke. Many drugs are available for managing these diseases, though common antihypertensive drugs are generally accompanied by many side effects. Medicinal herbs have several active substances with pharmacological and prophylactic properties that can be used in the treatment of hypertension. This review presents an overview of some medicinal plants that have been shown to have hypotensive or antihypertensive properties.

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“…Like synthetic drugs, plant-based formulations interact with the functions of molecules, and microorganism present in the human body. An understanding of the mechanism of action is essential then to recognize the accurate actions in order to, consequently, predict and prevent adverse events [17].…”

Section: Modern Applications Of Bioequivalence and Bioavailabilitymentioning

confidence: 99%