Anti-glycation, Carbonyl Trapping and Anti-inflammatory Activities of Chrysin Derivatives

Hwang, Seung Hwan; Kim, Hyun Yong; Zuo, Guanglei; Wang, Zhiqiang; Lee, Jae Yong; Lim, Soon Sung

doi:10.3390/molecules23071752

Cited by 31 publications

(28 citation statements)

References 38 publications

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“…Indeed, numerous investigations have determined that meta-dihydroxyl substituted aromatic nucleus constitutes the main site of scavenging action of flavonoids. Such patterns have been shown to generate nucleophilic site between to two phenolic groups that can be attacked by the electrophilic aldehyde group of MGO [37]. In line with this, structural analyses of MGO adducts of several common flavonoid derivatives including quercetin, apigenin and genistein have confirmed that positions 6 and 8 of their A ring were the major active sites for scavenging α-dicarbonyl compounds.…”

Section: Mgo Spiking Experiments For Detection Of Main Dicarbonyl Tramentioning

confidence: 69%

Screening and Characterization of Antiglycoxidant Anthocyanins from Vaccinium myrtillus Fruit Using DPPH and Methylglyoxal Pre-Column HPLC Assays

et al. 2020

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Vaccinium myrtillus fruit (bilberry) is well known for its high richness in anthocyanins, which may be responsible for its preventive effects on several oxidative and carbonyl stress-related pathologies. However, limited data are available regarding the antioxidant and antiglycative contributions of its constituents. Spectrometric analyses were performed to evaluate anthocyanin content, radical scavenging and antiglycative properties of an anthocyanin-rich extract from bilberries. Additionally, original DPPH and methylglyoxal pre-column HPLC methods were instigated to allow straightforward identification of the main contributors to radical and carbonyl trapping effects. Finally, representative pure anthocyanins were evaluated using classical DPPH and antiglycation assays. Delphinidin, petunidin and cyanidin glycosides were identified as the most effective radical scavenging constituents in both HPLC and spectrometric DPPH evaluations. Potent antiglycative activities were also assessed for cyanidin, delphinidin and petunidin glucosides as attested by their respective IC50 values of 114.2 ± 7.8, 130.5 ± 2.8, and 132.4 ± 3.7 µM. Interestingly, methylglyoxal spiking evaluation demonstrated that all bilberry anthocyanins exerted noticeable and comparable α-dicarbonyl trapping effects. Anthocyanins can be regarded as potent antiglycoxidant agents that might account for some health benefits of bilberries consumption. Besides, significant differences in their contributions were successfully highlighted by the employed pre-column HPLC assays.

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Section: Mgo Spiking Experiments For Detection Of Main Dicarbonyl Tramentioning

confidence: 69%

Screening and Characterization of Antiglycoxidant Anthocyanins from Vaccinium myrtillus Fruit Using DPPH and Methylglyoxal Pre-Column HPLC Assays

et al. 2020

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“…As active compounds widely distributed in foods, dietary flavonoids have shown inhibitory effects on formation of AGEs [10][11][12]. Moreover, they are identified as inhibitors of many human digestive enzymes, which makes them drug candidates for diabetes mellitus [13].…”

Section: Introductionmentioning

confidence: 99%

Influence of Human Serum Albumin Glycation on the Binding Affinities for Natural Flavonoids

Liu

Xiao

et al. 2019

Open Chemistry

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Increasing the degree of glycation in diabetes could affect the ability of plasma proteins in binding to small molecules and active compounds. In this study, the influence of glycation of Human serum albumin (HSA) on the binding affinities for six dietary flavonoids was investigated by fluorescence spectra. Glycated HSA was prepared through incubation with glucose and characterized by several methods to confirm the glycation. It was found that the level of glycation increased with the increasing incubation time. The glycation of HSA increased the binding affinities for flavonoids by 1.40 to 48.42 times, which indicates that modifications caused by the glycation may have different influences on the interactions of flavonoids with HSA at separate binding sites on this protein. These results are valuable for understanding the influence of diabetes on the metabolism of flavonoids and other bioactive small molecules in human body.

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“…Chrysin (5,7-dihydroxyflavone) is a flavonoid presents at high levels in propolis and honey [57]. It has a wide range of pharmacological properties, mainly antioxidant [58], anticancer [59], and anti-inflammatory [60]. It has been shown that chrysin, orally supplemented at 50 mg kg −1 day −1 , for 2 months, significantly increased the testicular level of glutathione as well as the activity of the antioxidant enzymes (catalase, glutathione peroxidase, and superoxide dismutase) [61].…”

Section: Main Textmentioning

confidence: 99%

Mechanisms of honey on testosterone levels

Banihani

2019

Heliyon

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Testosterone is an anabolic steroid and the principal sex hormone in males. Maintaining adequate levels of testosterone throughout the life span of male is very desirable, especially it is now well-known that low levels of testosterone is associated with various aging diseases/disorders. Therefore, still, so many research studies have focused on enhancing serum levels of testosterone in males. Here, we intended to systematically discuss and present the impact of honey on serum levels of testosterone in males. This was conducted by searching PubMed, Scopus, and Embase electronic databases for research articles from May 1993 through April 2019 using the keywords “honey” and “honeybee” versus “testosterone”. Moreover, references from relevant published articles were also reviewed and cited to frame an integral discussion, conclusion, and future research needs. In conclusion, the collective evidence, which is mainly based on in vivo system studies, reveals that oral administration of honey increases serum testosterone level in males. Mechanistically, honey may increase serum level of testosterone by increasing the production of luteinizing hormone, enhancing the viability of Leydig cells, reducing oxidative damage in Leydig cells, enhancing StAR gene expression, and inhibiting aromatase activity in the testes. However, further research studies on humans, mainly clinical trials, in this specific research approach are still needed to confirm the effect of honey on testosterone.

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Anti-glycation, Carbonyl Trapping and Anti-inflammatory Activities of Chrysin Derivatives

Cited by 31 publications

References 38 publications

Screening and Characterization of Antiglycoxidant Anthocyanins from Vaccinium myrtillus Fruit Using DPPH and Methylglyoxal Pre-Column HPLC Assays

Screening and Characterization of Antiglycoxidant Anthocyanins from Vaccinium myrtillus Fruit Using DPPH and Methylglyoxal Pre-Column HPLC Assays

Influence of Human Serum Albumin Glycation on the Binding Affinities for Natural Flavonoids

Mechanisms of honey on testosterone levels

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