Anti–Glutamic Acid Decarboxylase Antibodies in the Serum and Cerebrospinal Fluid of Patients With Stiff-Person Syndrome

Case report: Approaches to treatment-refractory and super-refractory glutamic acid decarboxylase antibody-spectrum disorders

“…There was no correlation between the quantitative antibody titer and the severity of the initial presentation, consistent with previous reports and current understandings ( 6 , 7 ). Seronegativity may be seen in up to 20% of cases ( 9 ), and CSF antibody testing should be considered if clinical suspicion remains high.…”

Case report: Approaches to treatment-refractory and super-refractory glutamic acid decarboxylase antibody-spectrum disorders

“…There was no correlation between the quantitative antibody titer and the severity of the initial presentation, consistent with previous reports and current understandings ( 6 , 7 ). Seronegativity may be seen in up to 20% of cases ( 9 ), and CSF antibody testing should be considered if clinical suspicion remains high.…”

GAD65 IgG autoantibodies in stiff person syndrome: clonality, avidity and persistence

“…This study confirms previous studies showing that SPS patients display high serum levels of GAD65 IgG, mainly of the IgG1 isotype, as well as persisting intrathecal synthesis of GAD65 IgG [9,11–13,16]. We here show that the intrathecally and systemically produced GAD65 IgG in SPS is oligoclonal and has high avidity which in some patients is higher in CSF than in serum.…”

Autologous hematopoietic stem cell transplantation for a patient with multiple autoimmune diseases

“…Our experience in AHSCT for the treatment of refractory SPS was consistent with previous studies. We also demonstrated the correlation between SPS‐related symptoms and levels of anti‐GAD65 antibody titers, which gradually decreased post‐transplant, inconsistent with prior reports which showed uncorrelation between clinical improvement and decreased antibody level 4,5,11,14,18 . We also noted the potential efficacy of AHSCT for patients with multiple autoimmune diseases caused by autoantibodies.…”

Case report: Approaches to treatment-refractory and super-refractory glutamic acid decarboxylase antibody-spectrum disorders

“…There was no correlation between the quantitative antibody titer and the severity of the initial presentation, consistent with previous reports and current understandings ( 6 , 7 ). Seronegativity may be seen in up to 20% of cases ( 9 ), and CSF antibody testing should be considered if clinical suspicion remains high.…”

GAD65 IgG autoantibodies in stiff person syndrome: clonality, avidity and persistence

“…This study confirms previous studies showing that SPS patients display high serum levels of GAD65 IgG, mainly of the IgG1 isotype, as well as persisting intrathecal synthesis of GAD65 IgG [9,11–13,16]. We here show that the intrathecally and systemically produced GAD65 IgG in SPS is oligoclonal and has high avidity which in some patients is higher in CSF than in serum.…”

Autologous hematopoietic stem cell transplantation for a patient with multiple autoimmune diseases

“…Our experience in AHSCT for the treatment of refractory SPS was consistent with previous studies. We also demonstrated the correlation between SPS‐related symptoms and levels of anti‐GAD65 antibody titers, which gradually decreased post‐transplant, inconsistent with prior reports which showed uncorrelation between clinical improvement and decreased antibody level 4,5,11,14,18 . We also noted the potential efficacy of AHSCT for patients with multiple autoimmune diseases caused by autoantibodies.…”

Case report: Approaches to treatment-refractory and super-refractory glutamic acid decarboxylase antibody-spectrum disorders

“…There was no correlation between the quantitative antibody titer and the severity of the initial presentation, consistent with previous reports and current understandings ( 6 , 7 ). Seronegativity may be seen in up to 20% of cases ( 9 ), and CSF antibody testing should be considered if clinical suspicion remains high.…”

GAD65 IgG autoantibodies in stiff person syndrome: clonality, avidity and persistence

“…This study confirms previous studies showing that SPS patients display high serum levels of GAD65 IgG, mainly of the IgG1 isotype, as well as persisting intrathecal synthesis of GAD65 IgG [9,11–13,16]. We here show that the intrathecally and systemically produced GAD65 IgG in SPS is oligoclonal and has high avidity which in some patients is higher in CSF than in serum.…”

Autologous hematopoietic stem cell transplantation for a patient with multiple autoimmune diseases

“…Our experience in AHSCT for the treatment of refractory SPS was consistent with previous studies. We also demonstrated the correlation between SPS‐related symptoms and levels of anti‐GAD65 antibody titers, which gradually decreased post‐transplant, inconsistent with prior reports which showed uncorrelation between clinical improvement and decreased antibody level 4,5,11,14,18 . We also noted the potential efficacy of AHSCT for patients with multiple autoimmune diseases caused by autoantibodies.…”