Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion

Use of aprotinin in cardiac surgery: effectiveness and safety in a population-based study☆

“…These findings are at least partly in accordance with findings from a Cochrane review [8], other observational studies [2,20] and the BART study [1], which reported a moderate to no effect of AP on blood loss and massive bleeding as compared with other systemic antifibrinolytic agents. The increased use of plasma and thrombocytes may partly be explained by the fact that more patients in the TA group had postoperative bleeding >1000 ml, which is the more likely to be substituted than patients bleeding <400 ml postoperative.…”

Use of aprotinin in cardiac surgery: effectiveness and safety in a population-based study☆

“…These findings are at least partly in accordance with findings from a Cochrane review [8], other observational studies [2,20] and the BART study [1], which reported a moderate to no effect of AP on blood loss and massive bleeding as compared with other systemic antifibrinolytic agents. The increased use of plasma and thrombocytes may partly be explained by the fact that more patients in the TA group had postoperative bleeding >1000 ml, which is the more likely to be substituted than patients bleeding <400 ml postoperative.…”

A systematic review and meta‐analysis of the effect of prophylactic tranexamic acid treatment in major benign uterine surgery

“…The relatively high incidence of venous thrombosis in that study indicates potential differences in genetic, perioperative, or diagnostic factors compared with the other included trials. No serious adverse events were reported in any of the other studies in accordance with the literature …”

Tranexamic Acid Use in Knee and Shoulder Arthroscopy Leads to Improved Outcomes and Fewer Hemarthrosis‐Related Complications: A Systematic Review of Level I and II Studies

“…No complications were reported in any of the studies included in this review. This is consistent with previous works that have shown no increased risk of complications, and most specifically VTE events, with the use of TXA perioperatively 22 , 47 , 48 . It is possible that the relatively minor procedures being performed contributed to a lack of complications reported, as the complication risk of these procedures is relatively low at baseline.…”

Use of aprotinin in cardiac surgery: effectiveness and safety in a population-based study☆

“…These findings are at least partly in accordance with findings from a Cochrane review [8], other observational studies [2,20] and the BART study [1], which reported a moderate to no effect of AP on blood loss and massive bleeding as compared with other systemic antifibrinolytic agents. The increased use of plasma and thrombocytes may partly be explained by the fact that more patients in the TA group had postoperative bleeding >1000 ml, which is the more likely to be substituted than patients bleeding <400 ml postoperative.…”

A systematic review and meta‐analysis of the effect of prophylactic tranexamic acid treatment in major benign uterine surgery

“…The relatively high incidence of venous thrombosis in that study indicates potential differences in genetic, perioperative, or diagnostic factors compared with the other included trials. No serious adverse events were reported in any of the other studies in accordance with the literature …”

Tranexamic Acid Use in Knee and Shoulder Arthroscopy Leads to Improved Outcomes and Fewer Hemarthrosis‐Related Complications: A Systematic Review of Level I and II Studies

“…No complications were reported in any of the studies included in this review. This is consistent with previous works that have shown no increased risk of complications, and most specifically VTE events, with the use of TXA perioperatively 22 , 47 , 48 . It is possible that the relatively minor procedures being performed contributed to a lack of complications reported, as the complication risk of these procedures is relatively low at baseline.…”

Use of aprotinin in cardiac surgery: effectiveness and safety in a population-based study☆

“…These findings are at least partly in accordance with findings from a Cochrane review [8], other observational studies [2,20] and the BART study [1], which reported a moderate to no effect of AP on blood loss and massive bleeding as compared with other systemic antifibrinolytic agents. The increased use of plasma and thrombocytes may partly be explained by the fact that more patients in the TA group had postoperative bleeding >1000 ml, which is the more likely to be substituted than patients bleeding <400 ml postoperative.…”

A systematic review and meta‐analysis of the effect of prophylactic tranexamic acid treatment in major benign uterine surgery

“…The relatively high incidence of venous thrombosis in that study indicates potential differences in genetic, perioperative, or diagnostic factors compared with the other included trials. No serious adverse events were reported in any of the other studies in accordance with the literature …”

Tranexamic Acid Use in Knee and Shoulder Arthroscopy Leads to Improved Outcomes and Fewer Hemarthrosis‐Related Complications: A Systematic Review of Level I and II Studies

“…No complications were reported in any of the studies included in this review. This is consistent with previous works that have shown no increased risk of complications, and most specifically VTE events, with the use of TXA perioperatively 22 , 47 , 48 . It is possible that the relatively minor procedures being performed contributed to a lack of complications reported, as the complication risk of these procedures is relatively low at baseline.…”