Anti-diabetic efficacy and selective inhibition of methyl glyoxal, intervention with biogenic Zinc oxide nanoparticle

Manimegalai, S.; Chakraborty, Shreya; Balaji, Menaka Priya; Govindasamy, Rajakumar; Alahmadi, Tahani Awad; Obaid, Sami Al; Karuppusamy, Indira; Lan, Nguyễn Thúy; Brindhadevi, Kathirvel; Rajeswari, Devi

doi:10.1016/j.envres.2022.114475

Cited by 10 publications

(7 citation statements)

References 33 publications

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“…Polyphenols are organic molecules containing phenolic hydroxyl groups that can coordinate with various metal ions to form MPNs. MPNs are used to prepare an important class of nanoparticles containing polyphenols for drug delivery, disease treatment, and bioimaging given their advantages of simple synthesis, flexible structure, pH responsiveness, and good physiological stability. ,, Among them, Zn 2+ have been complexed with several organic ligands to develop antidiabetes agents with improved and/or broader pharmacological properties. − Accordingly, in the present study, we prepared an ECH-Zn based on the formaldehyde-assisted metal–ligand cross-linking strategy . Compared with ECH, ECH-Zn exerted a better therapeutic effect on skin glycation.…”

Section: Discussionmentioning

confidence: 99%

“… 24 , 40 , 41 Among them, Zn 2+ have been complexed with several organic ligands to develop antidiabetes agents with improved and/or broader pharmacological properties. 42 − 44 Accordingly, in the present study, we prepared an ECH-Zn based on the formaldehyde-assisted metal–ligand cross-linking strategy. 23 Compared with ECH, ECH-Zn exerted a better therapeutic effect on skin glycation.…”

Section: Discussionmentioning

confidence: 99%

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Echinacoside-Zinc Nanomaterial Inhibits Skin Glycation by Suppressing the Transcriptional Activation of the Receptor for Advanced Glycation End-Products

Sun

Hou

et al. 2023

ACS Nano

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Glycation is a nonenzymatically catalyzed spontaneous reaction that eventually leads to the formation of advanced glycation end-products (AGEs), which can bind to the receptor for AGEs (RAGE). The consequences are oxidative damage, an inflammatory response, and aging. In this work, we synthesized echinacoside-zinc coordination polymers (ECH-Zn) by using the coordination interaction between the catechol group of ECH and zinc ions. ECH-Zn was further wrapped with hyaluronic acid/poly (ethylenimine) (HA-PEI) to obtain spherical nanoparticle polymers of HA-PEI-coated ECH-Zn (PPZn). PPZn can enhance the uptake and utilization of ECH-Zn and also have a better antiglycation effect in the skin under the effect of promoting transdermal absorption of HA-PEI. Mechanistic studies at the cellular level showed that MDM2 can interact with STAT2 to form a transcriptional complex and thus promote RAGE transcriptional activation. In vitro and in vivo studies revealed that PPZn can decrease the expression and inhibit the interaction of the MDM2/STAT2 complex. It inhibited the function of the MDM2/STAT2 complex and suppressed the transcriptional activation of RAGE, thereby exerting antiglycation effects. In conclusion, this work provides a nanomaterial and elucidated a mechanism of anti-skin glycation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Echinacoside-Zinc Nanomaterial Inhibits Skin Glycation by Suppressing the Transcriptional Activation of the Receptor for Advanced Glycation End-Products

Sun

Hou

et al. 2023

ACS Nano

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“…Furthermore, ZnO-NPs not only prevent AGE formation but also inhibit protein structure changes, thereby hindering AGE formation. Moreover, the capacity of ZnO-NPs to mitigate oxidative stress, particularly by targeting advanced glycation end products, not only holds potential benefits for managing diabetes-related complications but also shows promise in addressing neurodegenerative disorders and other degenerative conditions [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

“…This process significantly contributes to the onset and progression of various diseases. In light of the detrimental impact of AGEs, numerous anti-glycating agents have been identified [ 32 ]. Nevertheless, there is an urgent need to explore more effective agents to address this serious clinical issue.…”

Section: Discussionmentioning

confidence: 99%

Aldose Reductase and Protein Glycation Inhibitory Activity of Dark Chocolate-Assisted Zinc Oxide Nanoparticles

Nair,

R V,

R P

2023

Cureus

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Introduction One of the most common health issues that the global population is dealing with is the associated complications of diabetes, which encompasses cataracts, peripheral neuropathy, vascular damage, impaired wound healing, retinal issues, and arterial wall stiffening. The present study is aimed to evaluate the effect of dark chocolate and its assisted zinc oxide nanoparticles against diabetes-associated complications. Materials and methods Zinc oxide nanoparticles were synthesized using commercially dark chocolate (DC-ZnO NP). The synthesized DC-ZnO NPs were evaluated against recombinant aldose reductase (AR) activity and the formation of advanced glycation end products (AGEs). Aminoguanidine and gallic acid were used as reference standards for AGE assay and sorbitol accumulation inhibition, respectively. Results The results of the present study showed that green synthesized DC-ZnO NP had a significant dose-dependent inhibitory activity on both AR and AGEs. The inhibitory activity was compared to that of quercetin and aminoguanidine, respectively. Conclusion Targeting the endogenous antioxidant systems like AGEs and AR enzymes seems to provide a promising therapeutic approach, thus concluding that ZnO-NP could be a promising agent for treating diabetes-related complications such as diabetic retinopathy, diabetic nephropathy, and diabetic neuropathy that provide grounds for further clinical investigations and trials.

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“…They favor targeted drug administration, biotechnology, and possible in vivo imaging due to their high surface areas, efficient quantum self-assembly, specialty functional groups, and the capability to couple with the molecule of importance. In addition, metallic nanoparticles have demonstrated many benefits that fabricate them attractive candidates for various applications [ [187] , [188] , [189] , [190] , [191] , [192] , [193] , [194] , [195] , [196] , [197] ]. These benefits include ease of fabrication, high entrapment efficiency, environmental friendliness, economy, stability, and repeatability.…”

Section: Metallic Nanoparticles Mediated Antidiabetic Agentsmentioning

confidence: 99%

Therapeutic strategy of biological macromolecules based natural bioactive compounds of diabetes mellitus and future perspectives: A systematic review

Shahzad,

Alzahrani,

Aziz Ibrahim

et al. 2024

Heliyon

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Anti-diabetic efficacy and selective inhibition of methyl glyoxal, intervention with biogenic Zinc oxide nanoparticle

Cited by 10 publications

References 33 publications

Echinacoside-Zinc Nanomaterial Inhibits Skin Glycation by Suppressing the Transcriptional Activation of the Receptor for Advanced Glycation End-Products

Echinacoside-Zinc Nanomaterial Inhibits Skin Glycation by Suppressing the Transcriptional Activation of the Receptor for Advanced Glycation End-Products

Aldose Reductase and Protein Glycation Inhibitory Activity of Dark Chocolate-Assisted Zinc Oxide Nanoparticles

Therapeutic strategy of biological macromolecules based natural bioactive compounds of diabetes mellitus and future perspectives: A systematic review

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