Anti-cancer potential of polysaccharide extracted from hawthorn (Crataegus.) on human colon cancer cell line HCT116 via cell cycle arrest and apoptosis

Ma, Lei; Xu, Guanying Bianca; Tang, Xinyu; Zhang, Cheng; Zhao, Wen; Wang, Jie; Chen, Hong

doi:10.1016/j.jff.2019.103677

Cited by 62 publications

(30 citation statements)

References 44 publications

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“…In the present study, we have evaluated the analgesic, anti-inflammatory, anticoagulant, and antidepressant activities of saffron ethanolic extracts in mice. The selection of 80% ethanol and/or ethanolic extracts was chosen for the study due to their efficiency against cancer [ 43 , 44 ], blood pressure [ 45 , 46 ], inflammation [ 47 ], and nociception [ 48 , 49 ]. None of the orally administered saffron extracts (800 mg/kg) caused any mortality or prominent behavioral abnormalities in mice during the 7-days acute toxicity study.…”

Section: Discussionmentioning

confidence: 99%

Potential Nutraceutical Benefits of In Vivo Grown Saffron (Crocus sativus L.) As Analgesic, Anti-inflammatory, Anticoagulant, and Antidepressant in Mice

Khan

Muhamad

Ismail

et al. 2020

Plants

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Crocus sativus, a medicinally important herbaceous plant, has been traditionally used to cure coughs, colds, insomnia, cramps, asthma, and pain. Moreover, the therapeutic applications of saffron include its immunomodulatory and anticancer properties. The current experimental analysis was performed to explore the potential nutraceutical efficacy of corm, leaf, petal, and stigma of saffron ethanolic extracts as analgesic, anti-inflammatory, anticoagulant, and antidepressant using hot plate, carrageenan-induced paw edema, capillary tube and forced swim test, respectively in mice. The results indicated that among all the extracts, stigma ethanolic extract (SEE) represented maximum latency activity (72.85%) and edema inhibition (77.33%) followed by petal ethanolic extract (PEE) with latency activity and edema inhibition of 64.06 and 70.50%, respectively. Corm ethanolic extract (CEE) and leaf ethanolic extract (LEE) displayed mild analgesic activity of 22.40% and 29.07%, respectively. Additionally, LEE (53.29%) and CEE (47.47%) exhibited mild to moderate response against inflammation. The coagulation time of SEE (101.66 s) was almost equivalent to the standard drug, aspirin (101.66 s), suggesting a strong anticoagulant effect followed by PEE (86.5 s). LEE (66.83 s) represented moderate inhibitory effect on coagulation activity while CEE (42.83 s) showed neutral effect. Additionally, PEE and SEE also expressed itself as potential antidepressants with immobility time ≤76.66 s, while CEE (96.50 s) and LEE (106.83 s) indicated moderate to mild antidepressant efficacy. Based on the in vivo activities, saffron extract, particularly SEE and PEE, can be used as a potential nutraceutical and therapeutic agent due to its significant pharmacological activities.

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Section: Discussionmentioning

confidence: 99%

Potential Nutraceutical Benefits of In Vivo Grown Saffron (Crocus sativus L.) As Analgesic, Anti-inflammatory, Anticoagulant, and Antidepressant in Mice

Khan

Muhamad

Ismail

et al. 2020

Plants

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“…This plant belongs to the genus Crataegus that occurs in Europe, Asia and North America [1]. Hawthorn berries are a source of polyphenolic compounds (procyanidins, flavanols, flavonols, C-glycosyl flavones, phenolic acids, anthocyanins and lignans) [2,3] showing high antioxidant, anti-thrombotic, anti-inflammatory, anticarcinogenic and hypolipemic potential [4][5][6][7][8][9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Process Efficiency and Energy Consumption during the Ultrasound-Assisted Extraction of Bioactive Substances from Hawthorn Berries

et al. 2021

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This study investigated the impact of sonication parameters on the efficiency of the extraction of bioactive substances from hawthorn berries. The ultrasonic treatment was performed in two modes: continuous and pulse. In the pulse mode, the samples were sonicated with the following processor settings: 1 s on-2 s off. The effective ultrasonic processor times were 5, 10, and 15 min, and the total extraction times were 15 min, 30 min, and 45 min. The content of total polyphenols and total anthocyanins was determined by a spectrophotometric method. We show that the operating mode of the processor affects extraction efficiency, energy consumption and unit energy inputs. Extraction supported by a pulsating ultrasonic field allowed saving from 20% to 51% of energy with a simultaneous higher efficiency of the process. In addition, we show that the unit energy consumption in the pulsed mode was about 40% to 68% lower than the energy consumption in the case of continuous operation.

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“…There are only two reports on the literature related with cytotoxic activity of Crataegus species. The % inhibition values of HCT116 (colorectal cancer) by Crataegus L. polysaccharide extract were reported as in a range from 20% to 80% between 125 and 1000 µg/mL concentrations (39). Ganie et al revealed that C. songarica methanol, ethanol and ethyl acetate extracts inhibited ~ 80%, 85%, 75% of SW480 (colorectal cancer) at 80 µg/mL concentration (40).…”

Section: Discussionmentioning

confidence: 99%

Antioxidant, Cytotoxic, and Enzyme Inhibitory Activities of Agropyron repens and Crataegus monogyna Species

Deveci¹,

Cayan²,

Karakurt³

et al. 2020

Eur J Biol

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The aim of this study was to investigate antioxidant, enzyme inhibitory and cytotoxic activities of Agropyron repens and Crataegus monogyna methanol extracts with total phenolic and flavonoid contents.Materials and Methods: Total phenolic and flavonoid contents of A. repens and C. monogyna methanol extracts were measured according to Folin Ciocalteu and aluminum nitrate methods, respectively. Antioxidant and enzyme inhibitory activities of the methanol extracts were tested spectrophotometrically. Also, cytotoxic activities of the methanol extracts against DLD-1 and CCD-18Co were investigated by using Alamar Blue assay.Results: C. monogyna methanol extract with the highest total phenolic and flavonoid contents (68.13±0.34 µg GAEs/mg extract and 36.91±0.17 µg QEs/mg extract, respectively) had the best antioxidant activity in β-carotene-linoleic acid (IC 50 : 32.72±0.15 µg/mL), CUPRAC (A 0.50 : 282.69±0.25 µg/mL), DPPH • (IC 50 : 71.69±0.85 µg/mL), and ABTS •+ (IC 50 : 40.43±0.55 µg/ mL) assays. A. repens methanol extract showed the highest effect against AChE (18.73±0.47 %), BChE (37.59±1.07 %), urease (89.18±0.84%), α-glucosidase (6.71±0.23 %), whereas C. monogyna methanol extract showed the highest effect against tyrosinase (30.52±1.00%) and α-amylase (37.24±0.06 %). Also, A. repens (IC 50 : 57.38 µg/mL) and C. monogyna (IC 50 : 54.04 µg/ mL) methanol extracts showed close cytotoxic activity on DLD-1. Conclusion:Antioxidant, cytotoxic, and enzyme inhibitory activities of A. repens and C. monogyna methanol extracts were investigated with total phenolic and flavonoid contents in this study. The results obtained with this study strengthen the potential of the studied plants as a new source for the discovery of antioxidant, cytotoxic, and enzyme inhibitor agents.

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Anti-cancer potential of polysaccharide extracted from hawthorn (Crataegus.) on human colon cancer cell line HCT116 via cell cycle arrest and apoptosis

Cited by 62 publications

References 44 publications

Potential Nutraceutical Benefits of In Vivo Grown Saffron (Crocus sativus L.) As Analgesic, Anti-inflammatory, Anticoagulant, and Antidepressant in Mice

Potential Nutraceutical Benefits of In Vivo Grown Saffron (Crocus sativus L.) As Analgesic, Anti-inflammatory, Anticoagulant, and Antidepressant in Mice

Process Efficiency and Energy Consumption during the Ultrasound-Assisted Extraction of Bioactive Substances from Hawthorn Berries

Antioxidant, Cytotoxic, and Enzyme Inhibitory Activities of Agropyron repens and Crataegus monogyna Species

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