Biochemical Pharmacology volume 80, issue 8, P1125-1132 2010 DOI: 10.1016/j.bcp.2010.06.031 View full text
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Yoshiyuki Mizushina, Jinhui Zhang, Angelo Pugliese, Sung-Hoon Kim, Junxuan Lü

Abstract: Penta-1,2,3,4,6-O-galloyl-beta-D-glucose (PGG) has been shown by us and others to inhibit the in vivo growth of human prostate cancer (PCa) xenografts in athymic nude mice and mouse lung cancer allograft in syngenic mice without evident adverse effect on their body weight. We observed a rapid inhibition of DNA synthesis in S-phase cells in PGG-exposed cancer cells and in PGG-treated isolated nuclei. The purpose of the present study was to test the hypothesis that PGG inhibits DNA replicative synthesis through…

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