Anti-cancer effects of curcumin on lung cancer through the inhibition of EZH2 and NOTCH1

Abstract

Curcumin is potentially therapeutic for malignant diseases. The mechanisms of this effect might involve a combination of antioxidant, immunomodulatory, proapoptotic, and antiangiogenic activities. However, the exact mechanisms are not fully understood. In the present study, we provided evidences that curcumin suppressed the expression of enhancer of zeste homolog 2 (EZH2) in lung cancer cells both transcriptionally and post-transcriptionally. Curcumin inhibited the expression of EZH2 through microRNA (miR)-let 7c and miR-101. Curcumin decreased the expression of NOTCH1 through the inhibition of EZH2. There was a reciprocal regulation between EZH2 and NOTCH1 in lung cancer cells. These observations suggest that curcumin inhibits lung cancer growth and metastasis at least partly through the inhibition of EZH2 and NOTCH1.

MiR‐101‐3p Regulates the Viability of Lung Squamous Carcinoma Cells via Targeting EZH2

“…The repression of EZH2 has been proved to be a possible therapeutic method for the treatment of malignant cancers [Bauge et al, ; Fillmore et al, ]. In 2016, Guo‐Qing et al suggested that curcumin can inhibit lung cancer by silencing gene EZH2 [Wu et al, ]. Moreover, recently the targeting relationship between miR‐101 and EZH2 has also been spotted.…”

Analysis of Cytotoxic Activity and Synergistic Effect of Curcuma Longa Extract in Combination with Prednisolone on Acute Lymphoblastic Leukemia Cell Lines

“…As a natural derivative of Curcuma Longa, CL extract demonstrates strong cancer chemopreventive properties through the activation of apoptosis or inhibition of the cell cycle (23,24). Numerous studies have revealed that CL extract causes anti-cancer activities in many types of malignancies either as single agent or in combination with other drugs (25)(26)(27)(28)(29)(30). In this study, we aimed at examining the anti-cancer activity of CL extract and its synergistic effect in combination with prednisolone on acute lymphoblastic leukemia Nalm-6 and REH cell lines.…”

Recent developments in nanomedicine for melanoma treatment

“…In the same way, zinc oxide nanoparticles can kill breast cancer cells and liver cells directly . Extracted from the rhizome of Curcuma longa as a phenolic pigment, curcumin has shown many attractive biomedical functions, including anti‐inflammatory, anti‐oxidant, and anti‐cancer effects . It can induce tumor cell cycle blockage and apoptotic cell death by downregulating oncogene expression and upregulating anti‐oncogene expression, interfering with p53‐related pathways and blocking nuclear factor (NF)‐κB activation .…”

“…[24][25][26] Extracted from the rhizome of Curcuma longa as a phenolic pigment, curcumin has shown many attractive biomedical functions, including antiinflammatory, anti-oxidant, and anti-cancer effects. 27 It can induce tumor cell cycle blockage and apoptotic cell death by downregulating oncogene expression and upregulating antioncogene expression, interfering with p53-related pathways and blocking nuclear factor (NF)-jB activation. 28,29 Arunraj et al synthesized curcumin nanospheres that showed good skin permeation and retention and could reduce melanoma growth by inhibiting glutathione S-transferase activity and COX-1/COX-2 enzymes, inducing apoptosis through the Fas receptor/caspase-8 pathway and down-regulating NF-jB signaling both in vitro and in vivo.…”