Anti-cancer Effect of Apigenin on Human Breast Carcinoma MDA-MB-231 through Cell Cycle Arrest and  Apoptosis

Lee, Hwan Hee; Cho, Hyosun

doi:10.4014/mbl.1809.09006

Cited by 4 publications

(3 citation statements)

References 31 publications

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“…It primarily targets the G2/M phase of the cell cycle, leading to a halt in cell division. Thus, inhibiting the progression of cancer cells through the cell cycle, apigenin can limit their proliferation and growth of cancer cells (Lee & Cho, 2019; Zhao et al, 2017). Furthermore, it was appraised that apigenin also inhibited cell migration/invasion, and enhanced apoptosis via elevating cleaved caspase‐3 and cleaved poly (ADP‐ribose) polymerase proteins and suppressing phosphorylation of ERK1/2/AKT/mammalian target of rapamycin (mTOR) proteins (Lee & Cho, 2019; Zhao et al, 2017).…”

Section: Contemporary Research On Promising Flavonoids Against Differ...mentioning

confidence: 99%

“…Thus, inhibiting the progression of cancer cells through the cell cycle, apigenin can limit their proliferation and growth of cancer cells (Lee & Cho, 2019; Zhao et al, 2017). Furthermore, it was appraised that apigenin also inhibited cell migration/invasion, and enhanced apoptosis via elevating cleaved caspase‐3 and cleaved poly (ADP‐ribose) polymerase proteins and suppressing phosphorylation of ERK1/2/AKT/mammalian target of rapamycin (mTOR) proteins (Lee & Cho, 2019; Zhao et al, 2017). The correlation of cell cycle inhibition, overexpression of p21 protein and downregulation of CDK6, cyclin D1 as well as cyclin B1 has exhibited anticancer effects.…”

Section: Contemporary Research On Promising Flavonoids Against Differ...mentioning

confidence: 99%

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Flavonoids as promising anticancer therapeutics: Contemporary research, nanoantioxidant potential, and future scope

Gupta,

Ahmad,

Ahamad

et al. 2023

Phytotherapy Research

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Flavonoids are natural polyphenolic compounds considered safe, pleiotropic, and readily available molecules. It is widely distributed in various food products such as fruits and vegetables and beverages such as green tea, wine, and coca‐based products. Many studies have reported the anticancer potential of flavonoids against different types of cancers, including solid tumors. The chemopreventive effect of flavonoids is attributed to various mechanisms, including modulation of autophagy, induction of cell cycle arrest, apoptosis, and antioxidant defense. Despite of significant anticancer activity of flavonoids, their clinical translation is limited due to their poor biopharmaceutical attributes (such as low aqueous solubility, limited permeability across the biological membranes (intestinal and blood‐brain barrier), and stability issue in biological systems). A nanoparticulate system is an approach that is widely utilized to improve the biopharmaceutical performance and therapeutic efficacy of phytopharmaceuticals. The present review discusses the significant anticancer potential of promising flavonoids in different cancers and the utilization of nanoparticulate systems to improve their nanoantioxidant activity further to enhance the anticancer activity of loaded promising flavonoids. Although, various plant‐derived secondary metabolites including flavonoids have been recommended for treating cancer, further vigilant research is warranted to prove their translational values.

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Section: Contemporary Research On Promising Flavonoids Against Differ...mentioning

confidence: 99%

Section: Contemporary Research On Promising Flavonoids Against Differ...mentioning

confidence: 99%

Flavonoids as promising anticancer therapeutics: Contemporary research, nanoantioxidant potential, and future scope

Gupta,

Ahmad,

Ahamad

et al. 2023

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

“…Various studies show that API’s effect has offered growth inhibitory properties in breast cancer by apoptosis promotion via activating the caspase cascade [ 25 ]. In addition to delaying cell growth by directly affecting important cell cycle modulators, QU can induce apoptosis via the mitochondrial pathway by triggering Cyt c in the cytoplasm [ 39 , 40 ]. Various studies were carried out to elucidate the mechanism of BA-mediated anti-tumour activity, including apoptosis by mitochondrial outer membrane permeabilization [ 9 ].…”

Section: Cancer Microenvironmentmentioning

confidence: 99%

Immunomodulatory Effects of a Concoction of Natural Bioactive Compounds—Mechanistic Insights

Gangwar¹,

Garg²,

Lomore³

et al. 2021

Biomedicines

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Natural bioactive compounds derived from plant-based products are known for their biological immunomodulatory activities. They possess systemic pleiotropic effects, minimal side effects, and very low toxicities. Plant-based bioactive compounds have tremendous potential as natural therapeutic entities against various disease conditions and act as anti-inflammatory, antioxidant, anti-mutagenic, anti-microbial, anti-viral, anti-tumour, anti-allergic, neuroprotective, and cardioprotective agents. A herbal formulation extract including five biologically active compounds: Apigenin, Quercetin, Betulinic acid, Oleanolic acid, and β-Sitosterol can impart several immunomodulatory effects. In this review, we systematically present the impact of these compounds on important molecular signaling pathways, including inflammation, immunity, redox metabolism, neuroinflammation, neutropenia, cell growth, apoptosis, and cell cycle. The review corroborates the beneficial effect of these compounds and shows considerable potential to be used as a safer, more cost-effective treatment for several diseases by affecting the major nodal points of various stimulatory pathways.

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Recent Advances in the Pharmacological Actions of Apigenin, Its Complexes, and Its Derivatives

Zhou

et al. 2022

Food Reviews International

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Anti-cancer Effect of Apigenin on Human Breast Carcinoma MDA-MB-231 through Cell Cycle Arrest and Apoptosis

Cited by 4 publications

References 31 publications

Flavonoids as promising anticancer therapeutics: Contemporary research, nanoantioxidant potential, and future scope

Flavonoids as promising anticancer therapeutics: Contemporary research, nanoantioxidant potential, and future scope

Immunomodulatory Effects of a Concoction of Natural Bioactive Compounds—Mechanistic Insights

Recent Advances in the Pharmacological Actions of Apigenin, Its Complexes, and Its Derivatives

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