Anti Cancer: DNA Topoisomerase Inhibitors

Denny, William A.

doi:10.1016/b978-0-12-409547-2.02669-x

Cited by 4 publications

(2 citation statements)

References 213 publications

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“…Etoposide is administered in cancers such as Ewing's sarcoma, testicular cancer, lung cancer, lymphoma, and Kaposi's sarcoma. It is known to form a complex with DNA and topoisomerase II, which stops the DNA strands from religation and thereby causes a break in the DNA strands [65]. Since cancer cells divide more rapidly, they depend more on topoisomerase II than normal cells.…”

Section: Epipodophyllotoxinsmentioning

confidence: 99%

Targeting Apoptotic Pathway of Cancer Cells with Phytochemicals and Plant-Based Nanomaterials

et al. 2023

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Apoptosis is the elimination of functionally non-essential, neoplastic, and infected cells via the mitochondrial pathway or death receptor pathway. The process of apoptosis is highly regulated through membrane channels and apoptogenic proteins. Apoptosis maintains cellular balance within the human body through cell cycle progression. Loss of apoptosis control prolongs cancer cell survival and allows the accumulation of mutations that can promote angiogenesis, promote cell proliferation, disrupt differentiation, and increase invasiveness during tumor progression. The apoptotic pathway has been extensively studied as a potential drug target in cancer treatment. However, the off-target activities of drugs and negative implications have been a matter of concern over the years. Phytochemicals (PCs) have been studied for their efficacy in various cancer cell lines individually and synergistically. The development of nanoparticles (NPs) through green synthesis has added a new dimension to the advancement of plant-based nanomaterials for effective cancer treatment. This review provides a detailed insight into the fundamental molecular pathways of programmed cell death and highlights the role of PCs along with the existing drugs and plant-based NPs in treating cancer by targeting its programmed cell death (PCD) network.

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Section: Epipodophyllotoxinsmentioning

confidence: 99%

Targeting Apoptotic Pathway of Cancer Cells with Phytochemicals and Plant-Based Nanomaterials

et al. 2023

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“…In addition to the antibiotic activities, chartreusin displays substantial chemotherapeutic activities [ 57 ]. Its mode of action (MoA) is based on the inhibition of topoisomerase II during DNA synthesis [ 58 ].…”

Section: Resultsmentioning

confidence: 99%

A Regulator Based “Semi-Targeted” Approach to Activate Silent Biosynthetic Gene Clusters

Mingyar

Mühling

Kulik

et al. 2021

IJMS

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By culturing microorganisms under standard laboratory conditions, most biosynthetic gene clusters (BGCs) are not expressed, and thus, the products are not produced. To explore this biosynthetic potential, we developed a novel “semi-targeted” approach focusing on activating “silent” BGCs by concurrently introducing a group of regulator genes into streptomycetes of the Tübingen strain collection. We constructed integrative plasmids containing two classes of regulatory genes under the control of the constitutive promoter ermE*p (cluster situated regulators (CSR) and Streptomyces antibiotic regulatory proteins (SARPs)). These plasmids were introduced into Streptomyces sp. TÜ17, Streptomyces sp. TÜ10 and Streptomyces sp. TÜ102. Introduction of the CSRs-plasmid into strain S. sp. TÜ17 activated the production of mayamycin A. By using the individual regulator genes, we proved that Aur1P, was responsible for the activation. In strain S. sp. TÜ102, the introduction of the SARP-plasmid triggered the production of a chartreusin-like compound. Insertion of the CSRs-plasmid into strain S. sp. TÜ10 resulted in activating the warkmycin-BGC. In both recombinants, activation of the BGCs was only possible through the simultaneous expression of aur1PR3 and griR in S. sp. TÜ102 and aur1P and pntR in of S. sp. TÜ10.

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