volume 26, issue 3, P441-445 2011
DOI: 10.3233/jad-2011-110350
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Davide Vacirca, Cristiana Barbati, Beatrice Scazzocchio, Roberta Masella, Giuseppe Rosano, Walter Malorni, Elena Ortona

Abstract: Aside from being an integral protein involved in the synthesis and hydrolysis of ATP, Ecto-F1-ATPase plays a role in cholesterol homeostasis. We demonstrated the presence of autoantibodies to ecto-F1-ATPase (ASabs) in sera and cerebrospinal fluids from patients with Alzheimer's disease (AD). Herein we show that ASabs, unlike irrelevant antibodies, can increase cellular uptake of HDL, a risk factor for the development of AD, via a mechanism involving the prototypical function of ecto-F1-ATPase: the generation o…

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